A5002913240- Ginger and Zingiberaceae research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Phytochemical compounds biological activities
- Cell death mechanisms and regulation
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Curcumin's Biomedical Applications
- Essential Oils and Antimicrobial Activity
- Inflammatory mediators and NSAID effects
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Nephrotoxicity and Medicinal Plants
- Calpain Protease Function and Regulation
- Advancements in Transdermal Drug Delivery
- Bacteriophages and microbial interactions
- Cancer, Lipids, and Metabolism
- IL-33, ST2, and ILC Pathways
- NF-κB Signaling Pathways
University of Malaya
2012-2022
Institut des Sciences Biologiques
2017
MicroRNAs (miRNAs) have been extensively studied over the decades and proposed as potential molecular targets for cancer treatment. Studies shown that miR-378 participates in numerous biological processes various cancers; whereas miR-1827 has only reported pediatric glioma. The mechanism of how miRNAs modulate lung metastasis remains unclear. Our previous study demonstrated is up-regulated while down-regulated high invasive sub-cell lines, their functions described. Here, we report cell...
1'-(S)-1'-Acetoxychavicol acetate (ACA) isolated from the Malaysian ethno-medicinal plant Alpinia conchigera Griff. was investigated for its potential as an anticancer drug. In this communication, we describe cytotoxic and apoptotic properties of ACA on five human tumour cell lines. Data MTT viability assays indicated that induced both time- dose-dependent cytotoxicity all lines tested had no adverse effects normal cells. Total mortality entire population achieved within 30 hrs when treated...
<h3>Objective:</h3> Anoikis is apoptosis that induced when cells detach from the extracellular matrix and neighboring cells. As anoikis serves as a regulatory barrier, cancer often acquire resistance towards during tumorigenesis to become metastatic. MicroRNAs (miRNAs) are short strand RNA molecules regulate genes post-transcriptionally by binding mRNAs reducing expression of its target genes. This study aimed elucidate role novel miRNA, miR-6744-5p, in regulating breast identify gene....
MicroRNAs (miRNAs) are short non-coding RNAs that regulate genes posttranscriptionally.Past studies have reported miR-210 is up-regulated in many cancers including cervical cancer, and plays a pleiotropic role carcinogenesis.However, its regulating response towards anti-cancer agents has not been fully elucidated.We previously the natural compound 1'S-1'-acetoxychavicol acetate (ACA) able to induce cytotoxicity various cancer cells cells.Hence, this study aims investigate mechanistic of ACA...
Oral cancers although preventable, possess a low five-year survival rate which has remained unchanged over the past three decades. In an attempt to find more safe, affordable and effective treatment option, we describe here use of 1'S-1'-acetoxychavicol acetate (ACA), component Malaysian ginger traditionally used for various medicinal purposes.Whether ACA can inhibit growth oral squamous cell carcinoma (SCC) cells alone or in combination with cisplatin (CDDP), was explored both vitro using...
Lung cancer remains a major health problem with low 5-year survival rate of patients. Recent studies have shown that dysregulation microRNAs (miRNAs) are prevalent in lung and these aberrations play significant role the progression tumour progression. In present study, bioinformatics analyses was employed to predict potential miR-608 targets, which associated signaling pathways involved cancer. Luciferase reporter assay identified AKT2 as novel target miR-608, suppression its protein levels...
Background: Cervical cancer is the fourth most frequent malignancy affecting women worldwide, but drug resistance and toxicities remain a major challenge in chemotherapy. The use of natural compounds promising because they are less toxic able to target multiple signaling pathways. 1'S-1'-acetoxychavicol acetate (ACA), compound isolated from wild ginger Alpinia conchigera , induced cytotoxicity on various cells including cervical cancer. MicroRNAs (miRNAs) short noncoding RNAs that regulate...
The nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing (NLRP) 3 inflammasome is a multiprotein complex that triggers Caspase-1-mediated IL-1β production and pyroptosis, its dysregulation associated with the pathogenesis of inflammatory diseases. 1'-Acetoxychavicol acetate (ACA) natural compound in rhizome tropical ginger Alpinia species anti-microbial, anti-allergic anti-cancer properties. In this study, we found ACA suppressed NLRP3 activation mouse...
In this study, the apoptotic mechanism and combinatorial chemotherapeutic effects of cytotoxic phenylpropanoid compound 1'S-1'-acetoxyeugenol acetate (AEA), extracted from rhizomes Malaysian ethnomedicinal plant Alpinia conchigera Griff. (Zingiberaceae), on MCF-7 human breast cancer cells were investigated for first time. Data assays such as live dead poly-(ADP-ribose) polymerase cleavage indicated that AEA was able to induce apoptosis in cells, but not normal mammary epithelial cells. A...
// Norhafiza M. Arshad 1 , Lionel L.A. In 2 Tchen Lin Soh Mohamad Nurul Azmi 4 Halijah Ibrahim 3 Khalijah Awang Elena Dudich 6 Eduard Tatulov and Noor Hasima Nagoor 1,5 Institute of Biological Science (Genetics Molecular Biology), Faculty Science, University Malaya, Kuala Lumpur, Malaysia Department Biotechnology, Applied Sciences, UCSI University, (Ecology Biodiversity), Centre for Natural Product Research Drug Discovery (CENAR) Chemistry, 5 in Biotechnology Agriculture (CEBAR),...
Abstract Mycobacterium indicus pranii (MIP) is a non-pathogenic mycobacterium, which has been tested on several cancer types like lung and bladder where tumour regression complete recovery was observed. In discovering the potential cytotoxic elements, preliminary test carried out using four different fractions consisting of live bacteria, culture supernatant, heat killed bacteria supernatant MIP against two human cells A549 CaSki by 3-(4,5-dimethyl thiazol)-2,5-diphenyl tetrazolium bromide...
Geranylated 4-phenylcoumarins, DMDP-1 & -2 isolated from Mesua elegans were investigated for anticancer potential against human prostate cancer cells. Treatment with resulted in cell death a time and dose dependent manner an MTT assay on all lines tested the exception of lung adenocarcinoma showed highest cytotoxic efficacy PC-3 cells while DMDP-2 was most potent DU 145 Flow cytometry indicated that both coumarins successful to induce programmed after 24 h treatment. Elucidation...
Autophagy plays a role in deciding the fate of cells by inducing either survival or death. 1'S-1-acetoxychavicol acetate (ACA) is phenylpropanoid isolated from rhizomes Alpinia conchigera and has been reported previously on its apoptotic effects various cancers. However, effect ACA autophagy remains ambiguous. The aims this study were to investigate autophagy-inducing ability human non-small cell lung cancer (NSCLC), determine as pro-survival pro-death mechanism. Cell viability assay was...
The aim of this study was to determine the cytotoxic and apoptotic effects erythrocarpine E (CEB4), a limonoid extracted from Chisocheton erythrocarpus on human oral squamous cell carcinoma. Based preliminary dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays, CEB4 treated HSC-4 cells demonstrated effect inhibited proliferation in time dose dependent manner with an IC(50) value 4.0±1.9 µM within 24 h treatment. also found have minimal normal line, NHBE viability levels...