The discovery of a potential ligand-targeting G protein-coupled receptor 17 (GPR17) is important for developing chemotherapeutic agents against glioblastoma multiforme (GBM). We used the integration ligand- and structure-based cheminformatics experimental approaches identifying GPR17 ligand GBM treatment. Here, we identified novel indoline-derived phenolic Mannich base as an activator using molecular docking over 6000 indoline derivatives. One top 10 hit molecules, CHBC, with glide score...

Six new sulfonic acid-containing flavonoids, acidoflavanone (1), acidoauronol (2), 5-O-methylacidoauronol (3), acidoaurone (4), acidoisoflavone (5), and acidoflavonol (6), were isolated from the EtOH extract of roots Phyllanthus acidus. Their structures unambiguously established by interpretation their HRESIMS 1D 2D NMR data, single-crystal X-ray diffraction analysis, comparison to literature data. These represent first examples flavanones, auronols, aurones, isoflavones.

FDCA (2,5-furandicarboxylic acid) can be enzymatically converted from HMF (5-hydroxymethylfurfural). Pseudomonas putida S12 is promising for production, but generating stable P. difficult due to its polyploidy and lack of genome engineering tools. Here we showed that coupling CRISPR λ-Red recombineering enabled one-step gene integration with high efficiency frequency, simultaneously replaced endogenous genes in all chromosomes. Using this approach, generated two strains expressing...

The chemical investigation of the EtOAc extract Lobaria orientalis collected in southwestern part Central Vietnam led to isolation new β-orcinol depsidones, lobarientalones A and B (1 2), diphenyl ethers, lobariethers A–E (3–7). These types structures are often reported different lichen species, but absolute configuration stereogenic acetal center has not been defined. This is first assessment (1S) using electronic circular dichroism (ECD) spectroscopic data by comparison with ECD analogous...

Eight new peltogynoids, named bougainvinones A-H (1-8), were obtained from the stem bark of Bougainvillea spectabilis. Their structures elucidated by means physical data (1D and 2D NMR, HRESIMS) single-crystal X-ray crystallographic analyses. The a rare type modified flavonoids, are reported for first time this species genus Bougainvillea. All isolated compounds evaluated their cytotoxic effects against five cancer cell lines including KB, Hela S-3, HT-29, MCF-7, HepG2. Among them, compound...

Five new flavones possessing a fully substituted A-ring with C-6 and C-8 methyl groups, bougainvinones I - M (1: -5: ), along three known congeners, 2'-hydroxydemethoxymatteucinol (6: 5,7,3',4'-tetrahydroxy-3-methoxy-6,8-dimethylflavone (7: ) 5,7,4'-trihydroxy-3-methoxy-6,8-dimethylflavone (8: were isolated from the EtOAc extract of stem bark Bougainvillea spectabilis. Their structures established by means spectroscopic data (ultraviolet, infrared, high-resolution electrospray ionization...

Glioblastoma, an invasive high-grade brain cancer, exhibits numerous treatment challenges. Amongst the current therapies, targeting functional receptors and active signaling pathways were found to be a potential approach for treating GBM. We exploited role of endogenous expression GPR17, G protein-coupled receptor (GPCR), with agonist GA-T0 in survival RNA sequencing was performed understand association GPR17 LGG RT-PCR immunoblotting confirm mRNA its encoded protein. Biological functions...

Drug resistance and tumor heterogeneity limits the therapeutic efficacy in treating glioblastoma, an aggressive infiltrative type of brain tumor. GBM cells develops against chemotherapeutic agent, temozolomide (TMZ), which leads to failure treatment strategies. This enduring challenge drug could be rational by combinatorial targeted therapy. Here, we evaluated effect phenolic compound (2-(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol (THTMP), GPR17 agonist...

Introduction: Lumnitzera littorea grown at CanGio Mangrove Forest has been investigated. The present study reports the isolation, characterization and evaluation of alpha-glucosidase inhibitory activity isolated compounds from leaves.
 Methods: Their structures were elucidated by spectroscopic methods (including MS, 1D 2D–NMR) comparison with values literature. From n-hexane extract, nine including lupeol (1), betulin (2), betulinic acid (3), oleanolic (4), corosolic (5), -sitosterol...

Sonneratia alba J.E. Smith, Sonneratiaceae widely grows in mangrove forests. There were some studies on plants of forests, and these results showed they contained many interesting bioactive compounds. Nevertheless, has not much been studied, especially, yet chemically biologically studied Viet Nam. From the petroleum ether extract leaves Sonnertia alba, oleanolic acid (1), betulin (2), betulinic (3), alphitolic (4), methyl gallate (5) 5-hydroxymethylfurfural (6) isolated. Their structures...

Polyscias guilfoylei Bail has just studied by our group. From leaves of this plant, four compounds had been isolated: isophytol, oleanolic acid, 3-0-B-D glucopyranosylspinasterol and 3-0-B-D-glucopyranosyloleanolic acid [5]. Now we presented five saponins isolated from plant: B-D-glucuronopyranosyloleanolic (1), a mixture two 3-0-B-D-glucopyranosyl-(1→3)-B-D-glucuronopyranosyloleanolic (2a) 3-0-B-D-glucopyranosyl-(1→4)-B-D-glucurono-pyranosyloleanolic (2b) with the ratio (2:3),...

Avicennia officinalis L., Avicenniaceae (or Acanthaceae), is a wide spread plant in mangrove forest Vietnam, Cambodia, Thailand, Indonesia and so on.Some parts of this such as barks, leaves, fruits A. have been traditionally used an aphrodisiac, diuretic, hepatitis, leprosy treatment.Avicennia officinalis's chemical compositions remain mostly unknown not even studied Vietnam.Therefore, we now report on the isolation structural elucidation four flavonoids from growing Can Gio Ho Chi Minh...

Introduction: Dendriscosticta is a new genus belong the Sticta wrightii group of family Lobariaceae. This foliose lichen widely distributed in tropical regions worldwide. The platyphylloides very abundant Bidoup forest, Lam Dong province, Vietnam. Methods: structure these compounds was elucidated through interpretation their 1D and 2D-NMR HR-MS data. cytotoxic activities against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), epithelial (HeLa) breast (MCF-7) cell lines...

Introduction: Olax imbricata, owning antibacterial, antioxidant, and anti-inflammatory activities, has been investigated as one of traditional diabetic plants in Vietnam. In our previous publications on the structure analysis isolated compounds were reported, including two phenolic compounds, three glycosidic a sesquiterpenoid tropolone 1,2,3,4-tetrahydronaphthalene derivatives. This article described isolation elucidation triterpenoid glycosides from methanol extract imbricata growing Phu...

Two previously unreported dimethylpyranoflavanones, pyronomelodorones A and B (1 2), along with five known compounds, 7-O-methyldihydrowogonin (3), 5,6,7-trimethoxyflavanone (4), 5,6-dihydroxy-7-methoxy-dihydroflavone (5), 5,7,8-trimethoxydihydroflavone (6), pinostrobin (7), were isolated from the roots of Melodorum fruticosum. The structures all isolates fully characterized using spectroscopic data comparison previous literature. All evaluated for their in vitro α-glucosidase inhibition...

The human Guanine Protein coupled membrane Receptor 17 (hGPR17), an orphan receptor that activates uracil nucleotides and cysteinyl leukotrienes is considered as a crucial target for the neurodegenerative diseases. Yet, detailed molecular interaction of potential synthetic ligands GPR17 needs to be characterized. Here, we have studied comparative analysis on specificity GPR17-ligands with hGPR17 purinergic G protein-coupled (hP2Y1) receptors. Previously, simulated stability such T0510.3657,...

Wedelia trilobata Hitch. has not much been chemically and biologically studied. From the flower of trilobata, ten compounds were isolated: friedelan-3β-ol (or epifriedelanol) (1), erythrodiol (2), 28-hydroxy-3β -tetradecanoyloxyolean-12-ene 3β -tetradecanoyloxyerythrodiol) (3), 3β-henicosanoyloxyolean-12-en-28-oic acid (4), 3β-pentadecanoyloxyolean-28(13)-lactone (5), kaura-9(11),16-dien-18-oic grandiflorenic acid) (6), 2-(3-hydroxy-3,7,11,15-...

Parmotrema planatilobatum (Hale) Hale is a lichen which has not been chemically and biologically studied. From the collected in Viet Nam, seven compounds were isolated, including methyl β-orsellinate (1), orsellinate (2), orsellinic acid (3), haematommate (4), atranorin (5), lecanoric (6) (+)-(12R)-usnic (7). The structures of these elucidated by spectroscopic data compared with those references. This fisrt time that are known Hale.

To cope, preserve market position, and achieve sustainable competitive advantage (SCA), companies should put operations strategy into action systematically coherently. In this vein, the purpose of study is to evaluate small medium-sized (SME) pharmaceutical firms in southern Vietnam considering their current strategic orientation, development path, sustanability advantage. The method used research Sense Respond (S&R), supported with combination different tools. data has been gathered...