A5062705418- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Chemical synthesis and alkaloids
- Metabolomics and Mass Spectrometry Studies
- Synthetic Organic Chemistry Methods
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Alkaloids: synthesis and pharmacology
- Carbohydrate Chemistry and Synthesis
- Seaweed-derived Bioactive Compounds
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Activity
- Phytochemistry and Biological Activities
- Plant Pathogens and Fungal Diseases
- Coral and Marine Ecosystems Studies
- Marine Biology and Environmental Chemistry
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- Marine and coastal plant biology
- Biological Activity of Diterpenoids and Biflavonoids
- Microbial Metabolism and Applications
- Computational Drug Discovery Methods
University of French Guiana
2019-2025
Laboratoire écologie, évolution, interactions des systèmes amazoniens
2019-2025
Ifremer
2025
Amazon (Germany)
2025
Centre National de la Recherche Scientifique
2015-2024
Institut de Recherche pour le Développement
2022-2024
Université Paris Cité
2014-2021
Molécules de Communication et Adaptation des Micro-organismes
2018-2021
Délégation Paris 5
2014-2021
Muséum national d'Histoire naturelle
2019-2021
Natural products represent an inexhaustible source of novel therapeutic agents. Their complex and constrained three-dimensional structures endow these molecules with exceptional biological properties, thereby giving them a major role in drug discovery programs. However, the search for new bioactive metabolites is hampered by chemical complexity matrices which they are found. The purification single constituents from such requires significant amount work that it should be ideally performed...
Abstract Allelopathy has been recently suggested as a mechanism by which macroalgae may outcompete corals in damaged reefs. Members of the brown algal genus Lobophora are commonly observed close contact with scleractinian and have considered responsible for negative effects to corals. Recent field assays potential role chemical mediators this interaction. We performed situ bioassays testing allelopathy crude extracts isolated compounds several species, naturally associated or not corals,...
A new natural product named gambierone (1) was isolated from the cultured dinoflagellate Gambierdiscus belizeanus. The structure of this compound features an unprecedented polyether skeleton and unusual right-hand side chain. Its relative configuration fully determined by interpretation ROESY experiment comparison between experimental theoretical NMR data. Although succession cycles has no chemical similarity with ciguatoxins, 1 a molecular formula biological activity similar to those...
Filamentous fungi asymptomatically colonise the inner tissues of macroalgae, yet their ecological roles remain largely underexplored. Here, we tested if metabolites produced by fungal endophytes might protect host against a phylogenetically broad spectrum protistan pathogens. Accordingly, cultivable four brown algal species were isolated and identified based on LSU SSU sequencing. The metabolomes for ability to reduce infection pathogens in model Ectocarpus siliculosus. most active effective...
Five new hydantoin alkaloids, named parazoanthines A−E (1−5), were isolated as the major constituents of Mediterranean sea anemone Parazoanthus axinellae. Their structural elucidation was achieved through NMR spectroscopic and mass spectrometric analyses. The absolute configuration chiral compounds 1 4 determined by comparison between experimental TDDFT-calculated CD spectra. trisubstituted double bond 2, 3, 5 deduced from 3JH6−C4 coupling constant value. This family alkaloids represents...
A novel family of antibiotics, MDN-0057 to MDN-0060 (1–4), was isolated from liquid cultures the fungus Ophiosphaerella korrae. These compounds incorporate two isocyanide groups in their complex structures that were elucidated by extensive spectroscopic analyses, including HRESIMS, and 1D 2D NMR experiments. The relative configurations determined using J-based configuration analyses interpretation key NOESY correlations consistent with existence a major conformation solution. Mosher ester...
The full chemical reinvestigation of the Mediterranean marine sponge Crambe crambe led to isolation and structural characterization 11 crambescin derivatives, including 8 new compounds, together with known crambescidin 816. HRMS/MS studies allowed complete assignment alkyl chain lengths these guanidine alkaloids while absolute configurations all compounds were inferred from comparison between experimental theoretical circular dichroism spectra. Crambescidin 816 was proven be more cytotoxic...
Abstract Motivation The annotation of natural products and more generally small molecules is one the major drawbacks in untargeted mass spectrometry analysis. Molecular networking has emerged as a structured way to organize mine data from tandem (MS/MS) experiments. Despite great potential this tool, usually performed manually by expert only few spectral libraries are available. Results Herein we propose web server silico metabolization metabolites that represents full implementation...
The red alga Asparagopsis taxiformis (Rhodophyta, Bonnemaisoniaceae) has been shown to produce a large diversity of halogenated volatile organic compounds, with one four carbons. As the distribution this may expand worldwide, we implemented research program that aims understand functions its specialized metabolome in marine ecosystems. Phytochemical investigations performed on A. gametophyte stages from Indian Ocean revealed two new highly brominated cyclopentenones named mahorone (1) and...
Pseudomonas aeruginosa displays an impressive metabolic versatility, which ensures its survival in diverse environments. Reported herein is the identification of rare azetidine-containing alkaloids from P. PAO1, termed azetidomonamides, are derived a conserved, quorum-sensing regulated nonribosomal peptide synthetase (NRPS) pathway. Biosynthesis azetidine motif has been elucidated by gene inactivation, feeding experiments, and biochemical characterization vitro, involves new...
Storage of secondary metabolites with a putative defensive role occurs in the so-called mantle dermal formations (MDFs) that are located more exposed parts body most and very likely all members an entire family marine mollusks, chromodorid nudibranchs (Gastropoda: Opisthobranchia). Given these structures usually lack duct system, mechanism for exudation their contents remains unclear, as does adaptive significance. One possible explanation could be they adapted so to preferentially attacked...
Tiacumicin B is an antibiotic endowed with the remarkable ability to interact a new biological target, giving it inestimable potential in context of ever-growing and worrisome appearance resistances bacteria mycobacteria antibiotics. The synthesis aglycone tiacumicin ready for glycosylation reported. key steps this approach are [2,3]-Wittig rearrangement, Pd/Cu-catalyzed allene–alkyne cross-coupling, E-selective cross-metathesis, final ring-size selective macrolactonization.
New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from fungus Talaromyces stipitatus. Their structures absolute configurations determined on basis of spectroscopic analyses, electronic circular dichroism, GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity these compounds was evaluated against a panel human pathogenic bacteria. Among them, H (5) exhibited...
Phytochemical investigation of the alkaloid extract Palicourea sessilis by LC-HRMS/MS using molecular networking and an in silico MS/MS fragmentation approach suggested presence several new monoterpene indole alkaloids. These compounds were isolated semipreparative HPLC, their structures confirmed means HRMS, NMR, ECD measurements as 4-N-methyllyaloside (3), 4-N-methyl-3,4-dehydrostrictosidine (4), 4β-hydroxyisodolichantoside (6), 4α-hydroxyisodolichantoside (7), well known alkaloids alline...
The phytochemical investigation of the lichen Parmotrema sancti‐angelii afforded three racemic compounds, sanctis A–C, which feature an original dibenzo‐2,8‐dioxabicyclo[3.3.1]nonane scaffold. These compounds were structurally characterized by extensive NMR spectroscopy analyses, comparison between experimental and theoretical spectroscopic data, X‐ray crystallography. metabolites are similar to procyanidin A display a methyl group instead pendant aromatic ring at C‐9, so far unprecedented...
Traditional natural products discovery workflows implying a combination of different targeting strategies, including structure- and/or bioactivity-based approaches, afford no information about new compound structures until late in the pipeline. By integrating MS/MS prediction module and collaborative library (bio)chemical transformations, we have developed platform, coined MetWork, that is capable anticipating structural identity metabolites starting from any identified compound. In our...
Sponge natural product biosynthesis: A highly sensitive in vivo protocol based on 14C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of origin pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline lysine are now proposed as early 2-aminoimidazole moieties oroidin respectively. Detailed facts importance to specialist readers published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
Abstract Metabolomics has recently proven its usefulness as complementary tool to traditional morphological and genetic analyses for the classification of marine invertebrates. Among metabolite-rich cnidarian order Zoantharia, Parazoanthus is a polyphyletic genus whose systematics phylogeny remain controversial. Within this genus, one most studied species, axinellae prominent in rocky shallow waters Mediterranean Sea NE Atlantic Ocean. Although different morphotypes can easily be...
New racemic dispiranic polyketides, tsavoenones A (1), B (2) and C (3), having a novel 1,7-dioxadispiro[4.0.4.4]tetradecane scaffold were isolated from the foliose lichen Parmotrema tsavoense. These compounds structurally elucidated by extensive NMR analyses, comparison between experimental theoretical 13C data X-ray crystallography. putative biosynthetic scenario for formation of 1-3 parmosidone D, meta-depsidone previously same material, was proposed. Tested its cytotoxicity, 1 displayed...