A5086322503- Inflammatory Bowel Disease
- Microscopic Colitis
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Fungal Infections and Studies
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Tumor Research and Treatment
- Drug-Induced Adverse Reactions
- Autoimmune and Inflammatory Disorders
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Gallbladder and Bile Duct Disorders
- Ginseng Biological Effects and Applications
- Potassium and Related Disorders
Assistance Publique – Hôpitaux de Paris
2018-2025
Hôpital Saint-Louis
2018-2025
Université Paris Cité
2016-2025
Inserm
2018-2025
Institut de recherche Saint-Louis
2019-2023
Méditerranée Infection Foundation
2019-2023
Aix-Marseille Université
2019-2023
Institut de Recherche pour le Développement
2019-2023
University of London Institute in Paris
2020-2023
Sorbonne Paris Cité
2020-2023
Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside proximity Lgr5 + intestinal stem cells (ISC) mitochondria critical for ISC-renewal differentiation. Here, we characterise ISC appearance under conditions describe role mitochondrial niche-maintenance. Design Ileal tissue samples from patients with CD, mouse models dysfunction (Hsp60 Δ/ΔISC ) CD-like ileitis...
Summary Background After ileocaecal resection for Crohn's disease ( CD ), inflammatory lesions frequently recur on the anastomosis and/or neo‐terminal ileum. Aim To identify predictors of early post‐operative endoscopic recurrence. Methods From September 2010 to 2017, REMIND group conducted a prospective nationwide study in nine French academic centres. Data were collected at time surgery and endoscopy, performed 6‐12 months after surgery. Endoscopic recurrence was defined as Rutgeerts score...
INTRODUCTION: Early ileocolonoscopy within the first year after surgery is gold standard to evaluate recurrence ileocolonic resection for Crohn's disease (CD). The aim of study was association between presence and severity anastomotic ileal lesions at early postoperative long-term outcomes. METHODS: REMIND group conducted a prospective multicenter study. Patients operated or CD were included. An performed 6 months surgery. endoscopic score describing separately built. Clinical relapse...
Intestinal tissue-resident memory CD8 T cells (Trm) are non-recirculating effector ideally positioned to detect and react microbial infections in the gut mucosa. There is an emerging understanding of Trm cell differentiation functions, but their implication inflammatory bowel diseases, such as Crohn's disease (CD), still unknown. Here, we describe human intestine expressing KLRG1 or CD103, two receptors E-cadherin. While CD103 present high numbers mucosa CD patients controls, increased...
Objective We used the postoperative recurrence model to better understand role of adherent and invasive Escherichia coli (AIEC) bacteria in Crohn’s disease (CD), taking advantage a well-characterised cohort. Design From prospective, multicentre cohort operated patients with CD, AIEC identification was performed within surgical specimen (M0) (N=181 patients) neoterminal ileum (n=119 patients/181) during colonoscopy 6 months after surgery (M6). Endoscopic graded using Rutgeerts’ index. The...
Abstract Despite the introduction of biological therapies, an ileocolonic resection is often required in patients with Crohn’s disease [CD]. Unfortunately, surgery not curative, as many will develop postoperative recurrence [POR], eventually leading to further bowel damage and a decreased quality life. The 8th Scientific Workshop ECCO reviewed available scientific data on both prevention treatment POR CD undergoing resection, dealing conventional well non-medical interventions, including...
Abstract Background Intestinal surgery is a key treatment for Crohn’s disease (CD). Large cohort data on perioperative management are vital to improve postoperative outcomes. This study aimed assess and compare preoperative characteristics across three large prospective studies of CD patients following ileocolic resection (ICR). Methods The IMPACT consortium (International Multidisciplinary Research Collaboration Postoperative IBD) an intercontinental initiative focused inflammatory bowel...
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis represent a global health issue as prevalence of 1% is expected in the western world by end this decade. These idiseases are associated with high oxidative stress that induces inflammatory pathways severely damages gut tissues. IBD patients suffer from antioxidant defenses weakening, through, for instance, an impaired activity superoxide dismutases (SOD) — catalyze dismutation or other endogenous enzymes...
Ileocolonic resection is frequently needed in the course of Crohn's disease [CD] treatment and post-operative recurrence extremely common. Our main objective was to analyse gene expression mucosa CD patients at time surgery endoscopy, order identify predictors mechanisms early endoscopic recurrence.We conducted transcriptome analyses on ileal samples collected from inflamed sections surgical specimens [n = 200], margins 149] neo-terminal ileum 6 months after 122]; these were compared with...
Abstract Background Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on presence microbial triggers. Increased abundance unknown Clostridiales microscopic detection filamentous structures close to epithelium Tnf ΔARE mice, a mouse model ileitis pointed towards segmented bacteria (SFB), commensal mucosal adherent bacterium involved ileal inflammation. Results We show that SFB strongly correlates severity two...
Abstract Postoperative recurrence [POR] after an ileocolonic resection with anastomosis is frequently encountered in patients Crohn’s disease. The 8th Scientific Workshop of ECCO reviewed the available evidence on pathophysiology and risk factors for POR. In this paper, we discuss published data role microbiome, mesentery, immune system genetic background. addition to investigating causative mechanisms POR, identification essential tailor preventive strategies. Potential clinical, surgical...
Despite the introduction of potent biologic therapies, many patients with Crohn's disease [CD] still require an ileocolonic resection [ICR] during course their disease. Furthermore, need redo ICR has not decreased over past few decades, highlighting for better strategies to prevent and treat postoperative recurrence [POR]. The first step develop such a strategy would be define standardise description POR adequate diagnostic instruments. In this article, we will describe different...
Lympho-epithelial interactions between intestinal T resident memory cells (Trm) and the epithelium have been associated with inflammatory bowel disease (IBD) activity. We developed ex vivo autologous organoid-mucosal cell cocultures to functionally assess lymphoepithelial in Crohn’s Disease (CD) patients compared controls. demonstrate direct epithelial death induced by mucosal CD but not These findings were positively correlated infiltration of organoids. This potential was inhibited...
Background and Aims The modified Rutgeerts' score (mRS) is widely used for the assessment of endoscopic postoperative recurrence (ePOR) in Crohn's disease (CD) after ileocolic resection to guide therapeutic decisions. To improve validity prognostic value this assessment, two new scores have been proposed. This study assessed interobserver agreement current ePOR CD. Methods Sixteen Dutch academic non-academic IBD specialists videos (n=71) CD patients (n=66) retrieved from nine centers. Each...
Objective T cells are major effectors of the antitumoural immune response. Their activation by tumour-associated antigens can unleash their proliferation and cytotoxic functions, leading to tumour cell elimination. However, tumour-related immunosuppressive mechanisms including overexpression checkpoints like programmed death protein-1 (PD-1), also engaged, promoting escape. Current immunotherapies targeting these pathways have demonstrated weak efficacy in colorectal cancer (CRC). It is thus...
Summary Background Risk stratification for endoscopic post‐operative recurrence (ePOR) in Crohn's disease (CD) is required to identify patients who would benefit most from initiation of prophylactic medication and intensive monitoring recurrence. Aims To assess the current evidence on patient‐related, microbial, surgical histopathological risk factors ePOR with CD after ileocolic (re‐)resection. Methods Multiple online databases (Embase, MEDLINE, Web Science Cochrane Library) were searched...
Studies of tissue regeneration and host-pathogen interactions using the model planarian Schmidtea mediterranea have been performed at an experimental temperature 19 °C. S. planarians exposed to °C-32 °C were observed for survival, mobility, feeding three months elimination Staphylococcus aureus pathogen over six days. died 30 after 18 days observation but tolerated temperatures up 28 with non-significant differences in mobility behavior. Genetic malleability tested by RNAi was still...
Key Clinical Message Olmesartan is an angiotensin II receptor antagonist which may cause severe sprue‐like enteropathy with duodenal villous atrophy. Skin lesions be associated as reported for the first time in our case. Clinicians should informed of this side effect and its reversibility after suspension drug.