A5049998373- Epigenetics and DNA Methylation
- Phytoestrogen effects and research
- Nutrition, Genetics, and Disease
- Inflammatory Bowel Disease
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Protein Hydrolysis and Bioactive Peptides
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Tannin, Tannase and Anticancer Activities
- Estrogen and related hormone effects
- Fatty Acid Research and Health
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Autoimmune and Inflammatory Disorders
- Prostate Cancer Diagnosis and Treatment
Université Paris Cité
2019-2022
Inserm
2019-2022
Institut de recherche Saint-Louis
2019-2022
University of London Institute in Paris
2019-2022
Imagerie Moléculaire et Stratégies Théranostiques
2017
Centre Jean Perrin
2012-2017
Université Clermont Auvergne
2012-2016
Marmara University
2016
Genetique Reproduction and Developpement
2015
H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, deregulation might play a role in tumor progression.We investigated genome-wide methylation profile using chromatin immunoprecipitation (ChIP) and 2X400K promoter microarrays to identify differentially-enriched regions biopsy samples from cancer patients. were assessed 34 tumors: 11 with Gleason score > 7 (GS 7), 10 ≤ 13 morphologically normal samples.Here, profiling identified an average 386...
The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. objective this study was analyze understand the mechanisms by which phytoestrogens act on chromatin in breast cancer cell lines.Two lines, MCF-7 MDA-MB 231, were treated genistein (18.5 µM), (78.5 (12.8 17β-estradiol (10 nM) suberoylanilide hydroxamic acid (1 µM) for 48 h. A control untreated cells...
Intestinal tissue-resident memory CD8 T cells (Trm) are non-recirculating effector ideally positioned to detect and react microbial infections in the gut mucosa. There is an emerging understanding of Trm cell differentiation functions, but their implication inflammatory bowel diseases, such as Crohn's disease (CD), still unknown. Here, we describe human intestine expressing KLRG1 or CD103, two receptors E-cadherin. While CD103 present high numbers mucosa CD patients controls, increased...
It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance mechanisms cancer carcinogenesis increasingly evident. In this study, the focus will be on histone modifications primary objectives map H3K27me3 marks quantify RAR beta 2, ER alpha, SRC3, RGMA, PGR, EZH2 gene expressions tissues compared normal tissues. addition, a data analysis was made connection with...
T cell clonal expansions are present in the inflamed mucosa of patients with Crohn’s disease (CD) and may be implicated postoperative recurrence after ileocolonic resection. Methods receptor (TCR) analysis was performed 57 included a prospective multicentre cohort. Endoscopic defined by Rutgeerts score >i0. DNA mRNA were extracted from biopsies collected surgical specimen endoscopy, analysed high throughput sequencing microarray, respectively. Results TCR repertoire CD displayed diverse...
Ileocolonic resection is frequently needed in the course of Crohn's disease [CD] treatment and post-operative recurrence extremely common. Our main objective was to analyse gene expression mucosa CD patients at time surgery endoscopy, order identify predictors mechanisms early endoscopic recurrence.We conducted transcriptome analyses on ileal samples collected from inflamed sections surgical specimens [n = 200], margins 149] neo-terminal ileum 6 months after 122]; these were compared with...
Aim: Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles. Patients & methods: 192 tumors divided into five (luminal A, luminal B HER2-, HER2+, HER2+ and basal-like) were evaluated for their modifications on gene promoters. Results: ANOVA analysis allowed to identify specific signatures according three groups of genes: hormonal receptor genes (ERS1, ERS2, PGR), modifying histones (EZH2, P300, SRC3) tumor suppressor (BRCA1). A similar...
In prostate cancer, DNA methylation is significantly associated with tumor initiation, progression, and metastasis. Previous studies have suggested that soy phytoestrogens might regulate at individual candidate gene loci they play a crucial role as potential therapeutic agents for cancer. The purpose of our study was to examine the modulation effects on genome-wide scale in regards Prostate cancer cell lines DU-145 LNCaP were treated 40 μM genistein 110 daidzein. DNMT inhibitor 5-azacytidine...
Major phytoestrogens genistein and daidzein have been reported to the ability reverse DNA methylation in cancer cell lines. The mechanism by which an inhibiting action on is not well understood. aim of this study was investigate effects soy natural estrogen 17β-estradiol (E2) determine whether one receptors mobilized for these compounds methylation. We also made a comparative with inhibitor (5-azacytidine) activator (budesonide). Three prostate lines, PC-3, DU-145, LNCaP, were treated 40 μM...
In men at high risk for prostate cancer, established clinical and pathological parameters provide only limited prognostic information. Here we analyzed a French cohort of 103 cancer patients developed gene panel model predictive outcome in this group patients. The comprised 15-gene TaqMan Low-Density Array (TLDA) card, with expressions compared to standardized reference. RQ value each was calculated, scoring system developed. Summing all the binary scores (0 or 1) corresponding 15 genes,...