A5089229799- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Microscopic Colitis
- Acute Kidney Injury Research
- Helicobacter pylori-related gastroenterology studies
- Chronic Kidney Disease and Diabetes
- Colorectal Cancer Surgical Treatments
- Pharmaceutical studies and practices
- Biosimilars and Bioanalytical Methods
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Metastasis and carcinoma case studies
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
- Artificial Intelligence in Healthcare and Education
- Esophageal Cancer Research and Treatment
- Pregnancy and Medication Impact
- Medical Device Sterilization and Disinfection
- Anorectal Disease Treatments and Outcomes
- Breast Lesions and Carcinomas
- Machine Learning in Healthcare
- Computational Drug Discovery Methods
Rambam Health Care Campus
2017-2025
Technion – Israel Institute of Technology
1997-2024
Hebrew University of Jerusalem
2023
Privacy restrictions limit access to protected patient-derived health information for research purposes. Consequently, data anonymization is required allow researchers initial analysis before granting institutional review board approval. A system installed and activated at our institution enables synthetic generation that mimics from real electronic medical records, wherein only fictitious patients are listed.This paper aimed validate the results obtained when analyzing structured research....
Abstract Background and study aims Rising prevalence of pancreatic cysts inconsistent management guidelines necessitate innovative approaches. New features large language models (LLMs), namely custom GPT creation, provided by ChatGPT can be utilized to integrate multiple settle inconsistencies. Methods A was developed provide guideline-based advice for cysts. Sixty clinical scenarios were evaluated both the gastroenterology experts. consensus reached between experts review accuracy...
Abstract Background Society guidelines on colorectal dysplasia screening, surveillance, and endoscopic management in inflammatory bowel disease (IBD) are complex, physician adherence to them is suboptimal. We aimed evaluate the use of ChatGPT, a large language model, generating accurate guideline-based recommendations for IBD line with European Crohn’s Colitis Organization (ECCO) guidelines. Methods 30 clinical scenarios form free text were prepared presented three separate sessions ChatGPT...
In a nationwide cohort, we aimed to compare the durability of infliximab and adalimumab as first biologic treatment in children with Crohn's disease (CD), stratified combotherapy or monotherapy.
Ileocolonic resection is frequently needed in the course of Crohn's disease [CD] treatment and post-operative recurrence extremely common. Our main objective was to analyse gene expression mucosa CD patients at time surgery endoscopy, order identify predictors mechanisms early endoscopic recurrence.We conducted transcriptome analyses on ileal samples collected from inflamed sections surgical specimens [n = 200], margins 149] neo-terminal ileum 6 months after 122]; these were compared with...
A rise in serum creatinine (SCr) is widely used for the detection and definition of evolving acute kidney injury (AKI). Yet, it takes time SCr to re-adjust response changes glomerular filtration rate (GFR), subtle transient GFR may remain concealed. Additionally, cannot differentiate altered hemodynamics pre-renal failure from true renal tissue injury, necessitating additional clinical laboratory diagnostic tools. While these features limit usefulness subsequently estimated (eGFR) at a...
The growing use of GLP-1 analogs for type 2 diabetes mellitus (DM2) and obesity necessitates studies about their in patients with inflammatory bowel diseases (IBD).
Background The overall risk of postcontrast acute kidney injury (PC-AKI) after computerized tomography (CT) is negligible, likely because the small volume injected iodinated contrast media required. However, safety media–enhanced CT in patients with advanced renal functional impairment, an established major factor for PC-AKI, unknown. Materials and Methods This a retrospective study using large data analysis hospitalized at single center. Adults undergoing or magnetic resonance imaging were...
Abstract Background Ulcerative colitis (UC) and colonic Crohn’s disease (CD), carries an increased risk of colorectal cancer, necessitating effective surveillance strategies. Dye spraying electronic virtual chromoendoscopy techniques enhance mucosal visualisation aid in dysplasia detection. We aim to presents the effectiveness characteristics (CE) a tertiary care center. Methods conducted retrospective cohort study inflammatory bowel (IBD) patients who underwent CE at our center between 2014...
Background Inhibitors of sodium-glucose co-transporter-2 (SGLT2i) were found to improve renal outcome in diabetic patients large prospective randomized trials. Yet, SGLT2i may acutely reduce kidney function through volume depletion, altered glomerular hemodynamics or intensified medullary hypoxia leading acute tubular injury (ATI). The aim this study was prospectively assess the pathophysiology (AKI) hospitalized while on SGLT2i, differing ATI from pre-renal causes using biomarkers.Methods...
Abstract Background In this nationwide study we aimed to compare the durability of first initiated biologic in Crohn’s disease [CD], stratified by monotherapy and combotherapy. Methods We used data from epi-IIRN cohort, which includes 98% Israeli inflammatory bowel population [2005–2020]. Durability was defined as consistent treatment without surgery or added medications [except for combination therapy with thiopurines methotrexate]. All comparisons were based on stringent propensity-score...
Abstract Background In this nationwide study, our objective was to compare the durability of first-line biologics in ulcerative colitis (UC), categorized into monotherapy and combotherapy with immunomodulators. Methods We utilized data from epi-IIRN cohort 2005 2020. Durability defined as consistent treatment without surgery. Comparisons were based on stringent propensity score-matching. Results included 15 111 patients UC, whom 2322 (15%) received biologics, a median follow-up 7.0 years...
Anti-drug antibodies (ADA) to anti-tumour necrosis factor (anti-TNF) therapy drive treatment loss of response. An association between intestinal microbial composition and response anti-TNF was noted. We therefore aimed assess the implications antibiotic treatments on ADA formation in patients with inflammatory bowel disease (IBD).We analysed data from epi-IIRN (epidemiology group Israeli IBD research nucleus), a nationwide registry all Israel. included treated who had available levels....
Hyperglycemia is associated with adverse outcomes in hospitalized patients. We aimed to assess the impact of glucose levels upon admission on subsequent deterioration or improvement kidney function inpatients a focus diabetes reduced baseline as possible modifiers this effect.Running retrospective cohort analysis, we compared patients normal vs. high admission. applied multivariable logistic regression models study association between renal and clinical outcomes. Interaction terms were used...
Introduction The potential adverse renal outcome among patients undergoing iodine-based contrast - enhanced computerized tomography (CT) has been questioned recently, given the caution undertaken in patients' selection, hydration protocols, and low radiocontrast volume, used with advanced imaging equipment. Materials Methods This study is a retrospective assessment of 12,580 hospitalized contrast-enhanced CT, compared 754 subjected to gadolinium-based magnetic resonance imaging, subsequent...