A5037885531- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Reproductive Physiology in Livestock
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders Research
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Eosinophilic Esophagitis
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diverticular Disease and Complications
- Cytomegalovirus and herpesvirus research
- Health Systems, Economic Evaluations, Quality of Life
- Iron Metabolism and Disorders
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Reproductive Biology and Fertility
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Clostridium difficile and Clostridium perfringens research
Technion – Israel Institute of Technology
2016-2025
Rambam Health Care Campus
2016-2025
Tel Aviv University
2022
Mount Sinai Hospital
2012-2016
Haifa Medical Center
2016
University of Toronto
2014
Rappaport Family Institute for Research in the Medical Sciences
2012-2013
Sinai Hospital
2010
The University of Texas Southwestern Medical Center
1990-1993
Vanderbilt University
1993
Background and study aims: Population-based screening for colorectal cancer is widely recommended, with conventional colonoscopy considered to be the preferred diagnostic modality. However, compliance low manpower capacity limited. Capsule endoscopy might therefore represent a desirable alternative strategy. Patients methods: The PillCam Colon capsule endoscope was prospectively tested in multicenter setting. indications enrolled patients included (43 %), postpolypectomy surveillance (26...
Summary Background Adalimumab is an effective treatment for Crohn's disease ( CD ). Anti‐adalimumab antibodies AAA ) and low trough serum drug concentrations have been implicated as pre‐disposing factors failure. Aims To assess adalimumab levels, to examine their association discriminatory ability with clinical response C‐reactive protein CRP Methods We performed a cross‐sectional study using sera from adalimumab‐treated patients. Demographical data, Montreal classification, regimen status...
Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal microbiota with host immune system in genetically susceptible individuals. The largest meta-analysis genome-wide association to date identified 71 CD–susceptibility loci individuals European ancestry. An important epidemiological feature CD that it 2–4 times more prevalent among Ashkenazi Jewish (AJ) descent compared non-Jewish Europeans (NJ). To explore genetic variation associated AJs, we conducted...
<h3>Objective</h3> Previous investigations of short-term outcomes after preoperative exposure to biological therapy in inflammatory bowel disease (IBD) were conflicting. The authors aimed assess postoperative patients who underwent abdominal surgery with recent anti-tumour necrosis factor therapy. <h3>Design</h3> A retrospective case-control study detailed matching was performed for subjects IBD and without biologics within 180 days surgery. Postoperative compared between the groups....
Vedolizumab (VDZ) is an anti-integrin monoclonal antibody effective in ulcerative colitis (UC) and Crohn's disease (CD). The aim of this study was to examine the "real world" efficacy safety VDZ a large national patient cohort.Patients with inflammatory bowel treated were prospectively followed for 14 weeks. Patients who completed induction protocol (week 0/2/6/14) or discontinued treatment before week adverse events (AEs) primary nonresponse included. outcome clinical remission at 14;...
A common genotypic basis for ulcerative colitis (UC) and Crohn's disease (CD) is implied by overlapping clinical characteristics, epidemiological studies, association of genes with both UC CD. We evaluated the overlap between CD genetic loci stratified pathogenetic pathways location. The allele frequencies six UC-associated 34 CD-associated single nucleotide polymorphisms (SNPs) were determined in a Canadian IBD cohort (n = 2374). Differences CD, UC, colon-only ileal controls analyzed...
Angiotensin II has been identified immunohistochemically in the ovaries of both rats and humans. Here we present evidence that angiotensin (an extremely vasoactive agent a wide range tissues) may be involved regulation major steroidogenic enzyme ovary, cholesterol side chain cleavage cytochrome P-450 (P-450scc), as well basic fibroblast growth factor (bFGF), which implicated an angiogenic bovine corpus luteum. We have used primary cultures luteal cells to examine effect its receptor...
To investigate the basis for pattern of ovarian steroid production during bovine estrous cycle, tissue concentrations major steroidogenic enzymes, 17α-hydroxylase cytochrome P-450 and cholesterol side-chain cleavage (cytochrome P-450scc), their respective electron donors, NADPH-cytochrome reductase adrenodoxin, were estimated compared with those nonsteroidogenic c oxidase F1-ATPase. The levels these enzymes in medium sized (9-11 mm) large (14-18 follicles after removal follicular fluid by...
Abstract Background Society guidelines on colorectal dysplasia screening, surveillance, and endoscopic management in inflammatory bowel disease (IBD) are complex, physician adherence to them is suboptimal. We aimed evaluate the use of ChatGPT, a large language model, generating accurate guideline-based recommendations for IBD line with European Crohn’s Colitis Organization (ECCO) guidelines. Methods 30 clinical scenarios form free text were prepared presented three separate sessions ChatGPT...
Progesterone and pregnenolone are metabolized to 17 alpha-hydroxysteroids by a cytochrome P450-dependent alpha-hydroxylase (P450c17). The same enzyme can also catalyze the removal of side-chain these alpha-hydroxylated steroids yield androstenedione dehydroepiandrosterone, respectively. We investigated metabolism progesterone monkey kidney tumor (COS 1) cells transfected with plasmid vector containing cDNA encoding complete amino acid sequence for human P450c17. Transfected COS 1 converted...
To investigate the molecular basis for pattern of ovarian steroid production during bovine estrous cycle, relative levels mRNA specific cholesterol side-chain cleavage cytochrome P-450,17αhydroxylase P-450, adrenodoxin, and low density lipoprotein receptor were determined in antral follicles differing size (<3–18 mm) corpora lutea from early, early-mid, late-mid, regressionary stages. Total poly(A)+ RNA was size-fractionated on agarose-formaldehyde gels, transferred to nylon filters...
Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors poor course. The aim this study was identify clinical genetic markers that can predict prognosis.Medical records UC ≥5 years follow-up DNA serum were retrospectively assessed. Immunochip used genotype loci associated immune mediated inflammatory disorders (IMIDs), bowel diseases, other single nucleotide polypmorphisms...
Ustekinumab is an effective treatment of Crohn's disease (CD). Real-world data addressing the efficacy and safety ustekinumab are scarce.Our aim was to assess in a large national patient cohort.A prospective multicenter study, which we followed patients with active CD treated for 24 weeks. Induction dose intravenous ranging from 260 520 mg, according body weight, by 90 mg doses given subcutaneously every 8 Clinical response defined as reduction at least 1 severity category, Harvey-Bradshaw...
Follicles were collected from cows and processed for electron microscopy immunofluorescent staining at the light microscope level. Key regulatory steroidogenic enzymes cholesterol side-chain-cleavage cytochrome P-450 (P-450scc) 17 alpha-hydroxylase (P-45017 alpha) immunolocalized using specific IgG fractions raised against these enzymes. In larger follicles in which theca interna had differentiated, positive cytochromes P-450scc P-450(17) alpha was observed cells of interna. Electron...
Because the patents for biopharmaceutical monoclonal antibodies have or soon will expire, biosimilars are coming to market. This most likely lead decreased drug costs and so easier access these expensive agents. Extrapolation, however, of limited available clinical data from adults with rheumatologic diseases children inflammatory bowel disease (IBD) should be done caution needs some considerations.Postmarketing surveillance programs efficacy, safety, immunogenicity become mandatory in IBD...
Cytomegalovirus (CMV) is frequently detected in patients with ulcerative colitis (UC). The impact of CMV infection on the outcome UC exacerbation remains unclear. benefit combining antiviral anti-inflammatory treatment has not been evaluated yet. aim this study was to compare CMV-positive hospitalized treated therapy either alone or combined salvage (infliximab [IFX] cyclosporine A [CsA]).This a multicenter retrospective UC. were classified into 2 groups: antiviral-if antivirals alone;...
OBJECTIVE NOD2/CARD15 has been identified as a major susceptibility gene for Crohn's disease (CD). Three mutations, Arg702Trp, Gly908Arg, and Leu1007fsinsC, are associated with CD. The incidence prevalence rate of inflammatory bowel diseases is two- to four-fold higher in Ashkenazi Jews compared non-Jewish Caucasians. aim this study was determine the significance mutations Jewish CD patients Israel, more specifically, compare expression Sephardic populations. METHODS Allele frequencies were...