A5033239521- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Gut microbiota and health
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Rheumatoid Arthritis Research and Therapies
- Gallbladder and Bile Duct Disorders
- Inflammation biomarkers and pathways
- Esophageal Cancer Research and Treatment
- Respiratory and Cough-Related Research
- Gastrointestinal motility and disorders
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Immune Cell Function and Interaction
- Migraine and Headache Studies
- Galectins and Cancer Biology
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Screening and Detection
Centre Hospitalier Universitaire de Clermont-Ferrand
2014-2022
Microbe, Intestine, Inflammation and Host Susceptibility
2014-2021
Inserm
2015-2021
Université Clermont Auvergne
2016-2021
Centre Hospitalier Universitaire de Reims
2018
Université de Reims Champagne-Ardenne
2018
Clermont Université
2018
Centre Hospitalier de la Côte Basque
2018
Instituto de Gastroenterología
2016-2017
Laboratoire d'Aérologie
2017
Extraesophageal symptoms are common manifestations of gastroesophageal reflux disease (GERD). Lack a definitive diagnostic or treatment standards complicate management, which often leads to multiple specialty consultations, procedures, pharmaceuticals and tests. The aim this study was determine the economic burden associated with extraesophageal (EER).Direct costs evaluation were estimated for patients referred attributed EER between 2007 2011. Medicare payment management pharmaceutical...
Abstract Objective/Hypothesis: Pepsin lateral flow device (LFD) is a rapid noninvasive test to detect salivary pepsin as surrogate marker for gastroesophageal reflux disease (GERD). We aimed establish the sensitivity, specificity, positive and negative predictive values (PPV, NPV) in patients with symptomatic objective evidence of GERD compared healthy controls. Study Design: Prospective, blinded, controlled cohort study. Methods: A total 230 samples were analyzed. In vitro bench testing was...
Fundoplication is considered in patients with refractory extraesophageal reflux symptoms. However, postoperative symptom resolution inconsistent. This analysis investigates which presenting symptoms and preoperative objective parameters predict improvement.Retrospective cohort study.A total of 237 referred for to medical therapy underwent esophageal function testing. was performed 27 evidence gastroesophageal disease. Symptomatic improvement assessed at intervals. Logistic regression...
Summary Background Magnetic resonance entero‐colonography enables accurate assessment of ileocolonic Crohn's disease, but the need for bowel cleansing and rectal enema limits considerably its use in daily practice. Aim We evaluated accuracy diffusion‐weighted magnetic with neither nor to assess endoscopic activity. Methods Forty‐four disease patients underwent prospectively consecutively [with apparent diffusion coefficient ( ADC ) Clermont score calculation] ileocolonoscopy Disease...
Ileal lesions of Crohn's disease [CD] patients are colonised by adherent-invasive Escherichia coli [AIEC] able to survive in macrophage cell lines. We analysed the ability monocyte-derived macrophages [MDM] from CD control AIEC intracellular replication and pro-inflammatory cytokine response infected-MDM. Peripheral blood MDM were obtained 24 genotyped for NOD2 ATG16L1 mutations, 5 ulcerative colitis [UC] 12 healthy controls [HC]. The numbers bacteria determined using gentamicin assay....
Inflammatory bowel diseases (IBD) are systemic, chronic inflammatory conditions that predominately affect the gastrointestinal tract and can induce abdominal pain. Besides, many IBD patients complain about headaches in daily practice. The objective was to assess prevalence of headaches, including migraines pain with neuropathic characteristics (NC), compared historical controls from general population.Overall, 203 consecutive tertiary-care centre completed validated self-administered...
Fecal biomarkers are emerging tools in the assessment of mucosal healing inflammatory bowel diseases (IBD).We aimed to evaluate accuracy fecal matrix metalloprotease-9 (MMP-9) and lipocalin-2 (LCN-2) compared with calprotectin detecting endoscopic activity IBD STUDY:: Overall, 86 adults underwent colonoscopy consecutively prospectively, Crohn's disease Endoscopic Index Severity (CDEIS) (CD) patients or Mayo subscore calculation for ulcerative colitis (UC) patients, stool collection. was...
Summary Background Faecal biomarkers are emerging tools in the assessment of mucosal healing inflammatory bowel diseases ( IBD s). Aim To evaluate accuracy faecal chitinase 3‐like 1( CHI 3L1) compared to calprotectin detecting endoscopic activity . Methods Overall, 86 adults underwent colonoscopy consecutively and prospectively, with Crohn's disease Endoscopic Index Severity CDEIS ) or Mayo subscore calculation for ulcerative colitis, stool collection. was measured using quantitative...
Among the different mechanisms involved in irritable bowel syndrome (IBS) physiopathology, visceral hypersensitivity seems to play a key role. It involves sensitization of colonic primary afferent fibers, especially through an overexpression ion channels. The aims this translational study were investigate expression Cav 3.2 calcium channels and their involvement animal model hypersensitivity, assess mucosa symptomatic IBS patients.This bench-to-bed combined preclinical experimental on mice...
Magnetic resonance imaging [MRI] is a promising tool to evaluate therapeutic efficacy in ileocolonic Crohn's disease [CD].We aimed assess the feasibility of early MRI evaluation (week 12 [W12]) predict corticosteroid-free remission [CFREM] at W52 and prevent long-term bowel damage.All patients with active CD needing anti-tumour necrosis factor [anti-TNF] therapy were consecutively enrolled this multicentre prospective study. was performed before starting therapy, W12 W52. CFREM defined as...
Ileocolonic resection is frequently needed in the course of Crohn's disease [CD] treatment and post-operative recurrence extremely common. Our main objective was to analyse gene expression mucosa CD patients at time surgery endoscopy, order identify predictors mechanisms early endoscopic recurrence.We conducted transcriptome analyses on ileal samples collected from inflamed sections surgical specimens [n = 200], margins 149] neo-terminal ileum 6 months after 122]; these were compared with...
Abstract Background Diagnostics for gastro‐esophageal reflux disease (GERD) are suboptimal because of limited sensitivity. We performed in vitro and vivo studies to systematically assess the performance characteristics an oropharyngeal pH probe. Methods In compared probe with a standard catheter liquid aerosolized solutions, 1–7. The accuracy measurements, deviation from target pH, time equilibrium were determined. Simultaneous distal esophageal measurements obtained 11 patients GERD....
Fecal calprotectin [fcal] is a biomarker of Crohn's disease [CD] endoscopic activity. Identifying the situations in which fcal less reliable remains unexplored. We aimed to determine factors influencing level CD. Overall, 53 CD patients consecutively and prospectively underwent colonoscopy, with Endoscopic Index Severity [CDEIS] calculation stool collection. Fcal was measured using quantitative immunochromatographic test. Correlation analysis done Pearson statistics. correlated CDEIS [0.66,...
Objectives/Hypothesis: Patients with extraesophageal symptoms are often suspected of having gastroesophageal reflux disease (GERD). However, the true prevalence and severity is not well studied. In this group patients, objectives our study were to determine esophageal acid exposure classify endoscopic findings. Study Design: Prospective cohort study. Methods: One hundred twenty-eight patients underwent 48 hours Bravo pH monitoring. Percent time that was <4 (total upright supine) measured....