A5001200598- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Microscopic Colitis
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Surgery and Complications
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Intestinal and Peritoneal Adhesions
- Stoma care and complications
- Pelvic floor disorders treatments
- Autoimmune and Inflammatory Disorders
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Hernia repair and management
- Clinical Nutrition and Gastroenterology
- Eosinophilic Esophagitis
- Pelvic and Acetabular Injuries
- Intestinal Malrotation and Obstruction Disorders
- Nutrition and Health in Aging
- Intraperitoneal and Appendiceal Malignancies
- Nosocomial Infections in ICU
IJsselland Ziekenhuis
2017-2025
Erasmus MC
2021-2025
Erasmus University Rotterdam
2022
Amsterdam UMC Location University of Amsterdam
2007-2020
University of Amsterdam
2007-2020
University of Birmingham
2020
Chesterfield Royal Hospital NHS Foundation Trust
2020
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
2020
Dorset County Hospital NHS Foundation Trust
2020
East Kent Hospitals University NHS Foundation Trust
2020
In patients with severe secondary peritonitis, there are 2 surgical treatment strategies following an initial emergency laparotomy: planned relaparotomy and only when the patient's condition demands it ("on-demand"). The on-demand strategy may reduce mortality, morbidity, health care utilization, costs. However, randomized trials have not been performed.To compare patient outcome, costs of relaparotomy.Randomized, nonblinded clinical trial at academic 5 regional teaching hospitals in...
<h2>Summary</h2><h3>Background</h3> Closure of an abdominal stoma, a common elective operation, is associated with frequent complications; one the commonest and impactful incisional hernia formation. We aimed to investigate whether biological mesh (collagen tissue matrix) can safely reduce incidence hernias at stoma closure site. <h3>Methods</h3> In this randomised controlled trial (ROCSS) done in 37 hospitals across three European countries (35 UK, Denmark, Netherlands), patients aged 18...
To determine to what extent patients who have survived abdominal sepsis suffer from symptoms of posttraumatic stress disorder (PTSD) and depression, identify potential risk factors for PTSD symptoms.PTSD depression were measured using the Impact Events Scale-Revised (IES-R), Post-Traumatic Symptom Scale 10 (PTSS-10) Beck Depression Inventory II (BDI-II).A total 135 peritonitis eligible this study, whom 107 (80%) completed questionnaire. The median APACHE-II score was 14 (range 12-16), 89%...
Objective: The decision whether and when to perform a relaparotomy in secondary peritonitis is largely subjective based on professional experience. No existing scoring system aids this decisional process. Our aim was search for variables that could predict positive findings at relaparotomy. Design: Retrospective, clinical study. Setting: Tertiary university hospital. Patients: Two hundred nineteen patients of consecutive series who underwent an emergency laparotomy peritonitis....
Abstract Background To examine commonly used scoring systems, designed to predict overall outcome in critically ill patients, for their ability select patients with an abdominal sepsis that have ongoing infection needing relaparotomy. Methods Data from a RCT comparing two surgical strategies was used. The study population consisted of 221 at risk infection. following systems were evaluated logistic regression analysis requiring relaparotomy: APACHE-II score, SAPS-II, Mannheim Peritonitis...
Secondary peritonitis remains associated with high mortality and morbidity rates. Treatment of secondary is challenging even in modern medicine. Surgical intervention for source control the cornerstone treatment, beside adequate antimicrobial therapy resuscitation. A randomized clinical trial showed that relaparotomy on demand (ROD) after initial emergency surgery preferred treatment strategy, irrespective severity extent peritonitis. The effective safe use ROD requires intensive monitoring...
Abstract Purpose Complex abdominal wall repair (CAWR) in a contaminated operative field is challenge. Available literature regarding long-term outcomes of CAWR comprises studies that often have small numbers and heterogeneous patient populations. This study aims to assess modified-ventral hernia working group (VHWG) grade 3 repairs. Because the relevance recurrence (HR) as primary outcome for this contentious, need further surgery (FHS) was also assessed relation survival. Methods A...
The aim of this Delphi study was to reach consensus on a new clinical decision tool help identify or exclude Crohn's disease (CD) in patients with perianal fistula(s) (PAF). A panel international experts the field proctology/inflammatory bowel invited participate. In first round (electronic survey), participants were asked anonymously provide their opinion probing (1) relevance and use characteristics suggestive underlying CD, (2) fecal calprotectin (FCP) for screening (3) diagnostic work-up...
Abstract Background The predictive value of histopathologic features the intestinal resection specimen for risk Crohn’s disease (CD) recurrence after ileocolic (re-)resection (ICR) remains a matter debate. Therefore, this study assessed association histopathological in CD patients with (severe) endoscopic postoperative (ePOR) large prospective, multicenter cohort study. Methods (≥16 years) scheduled ICR were included from an ongoing prospective Outcome measures ePOR (modified Rutgeerts’...
Abstract Background Alterations in body composition are common among patients with Crohn’s disease (CD) and may represent a modifiable risk factor for dismal postoperative outcomes. This study aimed to investigate the association of preoperative complications endoscopic recurrence (ePOR) CD following ileocolic (re-)resection (ICR). Methods (≥16 years) scheduled ICR CT or MRI scan (&lt;12 months prior ICR) were identified from an ongoing prospective, multicenter cohort study....
Abstract Background Perianal fistulizing Crohn’s disease (pCD) is associated with debilitating symptoms such as fecal incontinence and perianal pain, can significantly impact a patient’s quality of life (QoL)1. The Anal Fistula Quality Life (CAF-QoL) scale has recently been developed the first disease-specific patient-reported outcome measure for patients pCD2, but yet to be validated in an independent cohort. Therefore, we aimed adapt validate CAF-QoL Dutch cohort active pCD. Methods...
Abstract Background Intestinal surgery is a key treatment for Crohn’s disease (CD). Large cohort data on perioperative management are vital to improve postoperative outcomes. This study aimed assess and compare preoperative characteristics across three large prospective studies of CD patients following ileocolic resection (ICR). Methods The IMPACT consortium (International Multidisciplinary Research Collaboration Postoperative IBD) an intercontinental initiative focused inflammatory bowel...
Transanal advancement flap repair (TAFR) fails in approximately 30–40% of patients with a cryptoglandular transsphincteric fistula. An additional intraoperative injection autologous platelet-rich stroma (PRS) TAFR proved to be safe, feasible, and effective the short term for treatment fistula tertiary referral center. In this study, we assessed long-term outcomes who were treated an PRS (n = 43). The majority (88%) had complex (high and/or multiple side tracts) underwent (one or more)...
ABSTRACT Background The impact of prophylactic medication following ileocecal resection (ICR) for Crohn's disease (CD) merits further elucidation. Prophylactic is recommended in patients with Crohn’s (CD), particularly at increased risk recurrence, but the on long‐term outcomes needs to be elucidated. Aim To evaluate effect postoperative prognosis. Methods A retrospective cohort study was performed CD who underwent primary ICR between 2000‐2020 Netherlands. Patients were divided into two...
Abstract Background This study aimed to compare laparoscopic lavage and sigmoidectomy as treatment for perforated diverticulitis with purulent peritonitis during a 36 month follow-up of the LOLA trial. Methods Within arm international, multicentre LADIES trial, patients were randomised between sigmoidectomy. Outcomes collected up months. The primary outcome present was cumulative morbidity mortality. Secondary outcomes included reoperations (including stoma reversals), rates, rates in group....
Abstract Background To prevent recurrence after ileocolonic resection [ICR] in Crohn’s disease [CD], postoperative prophylaxis based on risk stratification is recommended international guidelines. This study aimed to evaluate CD implementation of a clinical management algorithm and determine the predictive value histological factors [RFs]. Methods In this multicentre, prospective cohort study, patients [≥16 years] scheduled for ICR were included. The advised no medication low-risk patients,...
INTRODUCTION: The prognostic value of the modified Rutgeerts score (mRS) in patients with Crohn's disease (CD) needs to be further elucidated. This study assessed mRS for long-term outcomes after primary ileocecal resection CD. METHODS: Patients CD an available at first postoperative ileocolonoscopy (index mRS) were retrospectively included. outcome was surgical recurrence. Secondary clinical recurrence and progression severe endoscopic (≥i3). Cox proportional hazard models used assess...
Background and Aims The modified Rutgeerts' score (mRS) is widely used for the assessment of endoscopic postoperative recurrence (ePOR) in Crohn's disease (CD) after ileocolic resection to guide therapeutic decisions. To improve validity prognostic value this assessment, two new scores have been proposed. This study assessed interobserver agreement current ePOR CD. Methods Sixteen Dutch academic non-academic IBD specialists videos (n=71) CD patients (n=66) retrieved from nine centers. Each...
Patients undergoing surgery experience perioperative anxiety and pain. Music has been shown to reduce anxiety, pain medication requirement. This study assessed the feasibility effectiveness of implementing a music intervention.
This study aims to determine whether abdominal microbial profiles in early severe secondary peritonitis are associated with ongoing infection or death. The is performed within a randomized comparing two surgical treatment strategies patients (n = 229). of cultures retrieved from initial emergency laparotomy were tested logistic regression analysis for association 'ongoing needing relaparotomy' and in-hospital No profile the presence yeast Pseudomonas spp. was related risk relaparotomy....
Results of the first randomized trial comparing on-demand versus planned-relaparotomy strategy in patients with severe peritonitis (RELAP trial) indicated no clear differences primary outcomes. We now report full economic evaluation for this trial, including detailed methods, nonmedical costs, further differentiated cost calculations, and robustness different assumptions sensitivity analyses. An was conducted from a societal perspective alongside controlled 229 secondary an acute physiology...