A5040616920- Assistive Technology in Communication and Mobility
- Cerebral Palsy and Movement Disorders
- Mobile Health and mHealth Applications
- Stroke Rehabilitation and Recovery
- Family and Disability Support Research
- Technology Use by Older Adults
- Geriatric Care and Nursing Homes
- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Balance, Gait, and Falls Prevention
- Nutrition and Health in Aging
- Physical Activity and Health
- Innovative Approaches in Technology and Social Development
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Autism Spectrum Disorder Research
- Chronic Disease Management Strategies
- Spinal Cord Injury Research
- Social Robot Interaction and HRI
- Digital Mental Health Interventions
- Palliative Care and End-of-Life Issues
- Angiogenesis and VEGF in Cancer
- Healthcare innovation and challenges
- Health and Wellbeing Research
- Context-Aware Activity Recognition Systems
Erasmus MC
2024-2025
The Hague University of Applied Sciences
2022-2024
Argentine Antarctic Institute
2024
University of Sheffield
2017-2023
Tilburg University
2023
Maastricht University
2011-2020
Zuyd University of Applied Sciences
2011-2020
Maastricht University Medical Centre
2017-2018
Health & Life (Taiwan)
2018
Centre Eugène Marquis
2017
We cloned the cDNA for stem cell tyrosine kinase 1 (STK-1), human homolog of murine Flk-2/Flt-3, from a CD34+ hematopoietic cell-enriched library and investigated its expression in subsets normal bone marrow. The encodes protein 993 aa with 85% identity 92% similarity to Flk-2/Flt-3. STK-1 is member type III receptor family that includes KIT (steel factor receptor), FMS (colony-stimulating 1R), platelet-derived growth receptor. blood marrow restricted cells, population greatly enriched...
This is a position paper describing the elements of an international framework for assistive technology provision that could guide development policies, systems and service delivery procedures across world. It describes general requirements, quality criteria possible approaches may help to enhance accessibility affordable high solutions.The based on experience authors, analysis existing literature inputs from many colleagues in field provision. includes results discussions earlier version...
Prostacyclin (PGI2) is a vasoactive prostaglandin synthesized by vascular endothelial and smooth muscle cells. In order to investigate whether plasma lipoproteins influence the biosynthesis release of prostacyclin tissues, human high density (HDL) low (LDL) were incubated with porcine arterial cells grown in tissue culture. PGI2 production was measured radioimmunoassay its stable metabolite, 6-keto-PGF1 alpha. incubations HDL for 24 h, levels alpha medium increased significantly...
Wound repair and tumor vascularization depend upon blood vessel growth into hypoxic tissue. Although hypoxia slows endothelial cell (EC) proliferation suppresses EC basic fibroblast factor (bFGF) expression, we report that macrophages (MPs) exposed to PO2 approximately 12-14 torr (1 = 133.3 Pa) synthesize release in a time-dependent manner platelet-derived (PDGF) acidic/basic FGFs (a/bFGFs), which stimulate the of ECs. Chromatography MP-conditioned medium on immobilized heparin with an...
We used a recently developed system for real-time quantitative polymerase chain reaction (PCR) to determine residual disease in patients with chronic myeloid leukaemia. The expression of the Bcr-Abl hybrid oncogene was determined and normalized by using PBGD housekeeping gene product as endogenous reference. sensitivity reproducibility assay tested on cell line K562. A dilution Bcr-Abl-positive K562 remained positive at up 250 fg RNA. 10 copies DNA water could still be detected. dynamic...
New lymphatic growth may contribute to tumor metastasis. Activation of vascular endothelial factor receptor 3 (VEGFR-3) by its ligands VEGF-C and -D is necessary for embryonic lymphangiogenesis. However, the exact role VEGFR-3 signaling in adult lymphangiogenesis vessel survival regeneration unclear.A novel rat monoclonal antibody murine VEGFR-3, mF4-31C1, which potently antagonizes binding was developed. We tested effects systemic mF4-31C1 administration a mouse tail skin model...
To identify which caregivers of stroke patients living at home experience the highest levels strain and are risk burn-out, to investigate how support for could best be organized, when this should offered.Caregivers were recruited in four regions Netherlands. A total 212 interviewed. Multiple stepwise regression analysis was performed determine effects patient caregiver characteristics, resources, coping strategies duration role on strain, mental well-being vitality.The majority female...
Lipoprotein lipase (LPL) bound to the lumenal surface of vascular endothelial cells is responsible for hydrolysis triglycerides in plasma lipoproteins. Studies were performed investigate whether human lipoproteins and/or free fatty acids would release LPL which was cells. Purified bovine milk incubated with cultured porcine aortic resulting association enzyme activity When then media containing chylomicrons or very low density (VLDL), a concentration-dependent decrease cell-associated...
Over the years, several studies have been performed on subject of non-use provided assistive technology. All them report high rates non-use. In this literature overview determinants mentioned in that affect degree n
The 166-amino acid form of vascular endothelial growth factor (VEGF,,) is a mitogen for cells and potent angiogenic factor.Expression chimeric receptor containing the extracellular domain f l k -l fused to transmembrane intracellular domains human c-fma in NIH-3T3 cells, resulted appearance high affinity binding sites laaI-VEGF,, on transfected cells.The ' 261-VEGF1, flk-llfma as well VEGF,,induced autophosphorylation receptors were inhibited presence low concentrations heparin (1-10...