A5073906110- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Surgical Treatments
- Testicular diseases and treatments
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Anorectal Disease Treatments and Outcomes
- Radiation Therapy and Dosimetry
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Glutathione Transferases and Polymorphisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Risks and Factors
- Connective tissue disorders research
- Diagnosis and treatment of tuberculosis
- Kruppel-like factors research
- Hypertrophic osteoarthropathy and related conditions
- Plant Disease Resistance and Genetics
- Biomarkers in Disease Mechanisms
- Hepatitis B Virus Studies
Erasmus MC
2022-2025
Sinai Hospital
2025
Lunenfeld-Tanenbaum Research Institute
2025
Royal Dutch Kentalis
2025
Rigshospitalet
2023
University Medical Center Utrecht
2023
National Institute of Oncology
1984-2018
Heidelberg University
1989-1990
German Cancer Research Center
1989-1990
Abstract Background The predictive value of histopathologic features the intestinal resection specimen for risk Crohn’s disease (CD) recurrence after ileocolic (re-)resection (ICR) remains a matter debate. Therefore, this study assessed association histopathological in CD patients with (severe) endoscopic postoperative (ePOR) large prospective, multicenter cohort study. Methods (≥16 years) scheduled ICR were included from an ongoing prospective Outcome measures ePOR (modified Rutgeerts’...
Abstract Background Alterations in body composition are common among patients with Crohn’s disease (CD) and may represent a modifiable risk factor for dismal postoperative outcomes. This study aimed to investigate the association of preoperative complications endoscopic recurrence (ePOR) CD following ileocolic (re-)resection (ICR). Methods (≥16 years) scheduled ICR CT or MRI scan (<12 months prior ICR) were identified from an ongoing prospective, multicenter cohort study....
Abstract Background Intestinal surgery is a key treatment for Crohn’s disease (CD). Large cohort data on perioperative management are vital to improve postoperative outcomes. This study aimed assess and compare preoperative characteristics across three large prospective studies of CD patients following ileocolic resection (ICR). Methods The IMPACT consortium (International Multidisciplinary Research Collaboration Postoperative IBD) an intercontinental initiative focused inflammatory bowel...
In the Netherlands, access to deafblind-specific rehabilitation and education is often based on medical definitions for vision impairment hearing loss. However, not everyone with deafblindness (DB) meets these because DB solely a result of limitations in bodily functions structures, but also daily functioning. Therefore, using functional definition that describes disability terms its impact functioning, alongside definitions, would be better suited determining who needs support. such did yet...
Radiotherapy for vulvar carcinoma is challenging due to relatively high risk of locoregional disease recurrence, a technically target, and postoperative lymphocele, radiation sequelae. We aim explore, if it possible reduce dose normal tissue, while maintaining CTV coverage this patient group with online adaptive radiotherapy.20 patients (527 fractions) were treated adaptation on Varian Ethos accelerator. Setup CBCTs acquired daily planning. Verification immediately prior delivery. bladder...
High intrinsic chemoresistance contributes to the dismal outcome of patients with disseminated renal cell carcinoma (RCC). In experimental lines, two defined defence mechanisms, P-170 glycoprotein and glutathione metabolism, have been established in multidrug resistance, a cross-resistance cytotoxic compounds without functional or structural similarities. 21 primary human RCCs, expression was examined, content activities related enzymes determined results were correlated degree vitro...
Abstract Background Platelet-rich stroma (PRS), a combination of stromal vascular fraction and platelet-rich plasma, proved to be safe feasible for the treatment treatment-refractory perianal fistulizing Crohn’s disease (pCD). This study aimed assess long-term outcomes in patients with pCD treated PRS. Methods Long term results from adult pCD, who underwent fistula curettage, closure internal opening PRS injection, included an earlier conducted pilot (n=25) were assessed up October 2023. The...
Patients with stage II seminoma have traditionally been treated photons to the retroperitoneal and iliac space, which leads a substantial dose bath abdominal pelvic organs at risk (OAR). As these patients are young excellent prognosis, reducing OAR thereby of secondary cancer is utmost importance. We compared IMPT opposing IMRT fields VMAT, assessing both overall organ-specific risk.
BACKGROUND: A multicentre epidemiological survey was carried out in order to determine the prevalence of, and risk factors for, persistent cervical human papillomavirus (HPV) infection women Hungary. METHODS RESULTS: total of 728 were examined for HPV. The estimated overall rate HPV 17%. In univariate analysis strongest predictors young age (≤24 years), unmarried family status, smoking, a pathological Papanicolaou (Pap) smear, having condyloma previous gynaecological cancer (age marital...
Abstract Background Alterations in body composition are common Crohn’s disease (CD) patients and influence outcomes. However, the impact of preoperative on postoperative outcomes is not completely understood. Therefore, this study aimed to investigate association with complications endoscopic recurrence CD undergoing ileocolic (re-)resection (ICR). Methods (≥16 years) scheduled for an ICR a computed tomography (CT) scan available (<12 months prior ICR) were identified from ongoing...
Abstract Background The multitude of medical and surgical treatment options for perianal fistulizing Crohn’s disease (pCD) impels differences in management. This study aimed to assess management pCD current clinical practice the Netherlands. Methods Patients with active (i.e. visible external fistula opening or patent tract on imaging) were included a prospective multicenter cohort 41 Dutch academic non-academic hospitals from September 2022 March 2023. pCD-related clinical, radiological...
Abstract Background Further refinement of clinical risk stratification for postoperative endoscopic recurrence in patients with Crohn’s disease is required to identify who will benefit from prophylactic therapy. Therefore, we aimed assess factors a large prospective, multicenter cohort study. Methods CD (≥16 years) scheduled ileocolic (re-)resection (ICR) and those underwent an ileocolonoscopy at 6 months following ICR were included. Primary outcome the study was (modified Rutgeerts’ score ≥...
Abstract Background The modified Rutgeerts’ score (mRS) is widely used for the assessment of endoscopic postoperative recurrence (ePOR) in Crohn’s disease (CD) after ileocolic resection to guide therapeutic decisions. To improve validity and prognostic value this assessment, two new scores have been proposed. This study assessed interobserver agreement current ePOR CD. Methods Sixteen academic non-academic IBD specialists videos (n=71) CD patients (n=66) retrieved from nine Dutch centers....
Abstract Background Prophylactic medication following ileocecal resection (ICR) is recommended in patients with Crohn’s disease (CD), particularly at increased risk of recurrence. This study aimed to evaluate the effect prophylactic on long-term prognosis. Methods A retrospective cohort was performed CD who underwent a primary ICR. Patients were divided into two groups: prophylaxis (i.e. initiation medication<12 weeks ICR) versus no prophylaxis. The and secondary outcomes surgical...
Glutathione S-transferase (GST) isoenzymes alfa, mu and pi were assessed by Western blotting in normal testes, seminomas non-seminomatous germ cell tumors (NSGCTs). GST alfa strongly expressed all specimens (n = 6), the isoform, however, could not or barely be detected. Ten (92%) of 11 had only 2 (16%) showed expression. In contrast, twelve (80%) 15 NSGCTs a significant level (13%) The absence paucity isoform was characteristic for neoplastic testicular tissues. A statistically relationship...