A5004846049- HIV/AIDS Research and Interventions
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- HIV Research and Treatment
- Sex work and related issues
- Hepatitis B Virus Studies
- HIV, TB, and STIs Epidemiology
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Inflammatory Bowel Disease
- Genital Health and Disease
- Urinary Tract Infections Management
- Sexual Assault and Victimization Studies
- Intimate Partner and Family Violence
- Pneumocystis jirovecii pneumonia detection and treatment
- Clostridium difficile and Clostridium perfringens research
- Hepatitis Viruses Studies and Epidemiology
- Anorectal Disease Treatments and Outcomes
- Immune Cell Function and Interaction
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- COVID-19 and Mental Health
- Foot and Ankle Surgery
- Bacterial Infections and Vaccines
University Hospitals Sussex NHS Foundation Trust
2017-2025
IJsselland Ziekenhuis
2024-2025
United States Army Medical Research Institute of Infectious Diseases
2023
Brighton and Sussex Medical School
2018-2023
Royal Sussex County Hospital
2022
University of Brighton
2022
Sexual Health Clinic
2019-2020
Royal North Shore Hospital
2019-2020
Memorial Sloan Kettering Cancer Center
2018
University College London
2018
Surgical-site infection (SSI) is associated with significant healthcare costs. To reduce the high rate of SSI among patients undergoing colorectal surgery at a cancer centre, comprehensive care bundle was implemented and its efficacy tested.A pragmatic study involving three phases (baseline, implementation sustainability) conducted on treated consecutively between 2013 2016. The intervention included 13 components related to: bowel preparation; oral intravenous antibiotic selection...
Demographic data show an increasingly aging human immunodeficiency virus (HIV) population worldwide. Recent concerns over dolutegravir-related neuropsychiatric toxicity have emerged, particularly amongst older people living with HIV (PLWH). We describe the pharmacokinetics (PK) of dolutegravir (DTG) 50 mg once daily in PLWH aged 60 and older. Additionally, to address calls for prospective toxicodynamic data, we evaluated changes sleep quality cognitive functioning this after switching...
Abstract Background Hospitals in the southwest of Netherlands collaborate to improve inflammatory bowel disease (IBD) care. As part this initiative, a standardised care pathway (CP) for treatment IBD with biologics and small new molecules has been developed. The CP addresses initiation, switching, discontinuation therapy, as well diagnostic testing follow-up. implemented six eight hospitals patient outcomes, standardise reduce healthcare costs. This natural experiment provides an opportunity...
Abstract Background In the southwest of Netherlands, there is a close collaboration between hospitals to improve care for inflammatory bowel disease (IBD). This aims deliver high quality and uniform across region. To achieve this, pathway (CP) was developed implemented treating IBD with biologics small new molecules. The CP consists subsets that address initiation switching therapy, frequency type follow-up. study assess adherence determine barriers facilitators development implementation....
Abstract Background Perianal fistulizing Crohn’s disease (pCD) is associated with debilitating symptoms such as fecal incontinence and perianal pain, can significantly impact a patient’s quality of life (QoL)1. The Anal Fistula Quality Life (CAF-QoL) scale has recently been developed the first disease-specific patient-reported outcome measure for patients pCD2, but yet to be validated in an independent cohort. Therefore, we aimed adapt validate CAF-QoL Dutch cohort active pCD. Methods...
People living with HIV (PLWH) have a higher prevalence of mental ill health compared to the general population. We aimed understand impact COVID-19 pandemic and omitting routine appointments on (MH) PLWH. Between April 2020 March 2021, for "stable" PLWH were replaced by virtual consultations. MH assessments using standardised questionnaires before during pandemic. Full data available 426 individuals after excluding those incomplete requiring early review non-MH-related issues. The results...
We examined the impact of Covid-19 restrictions on wellbeing and access to care among people living with HIV (PLWH) in UK. A cross-sectional anonymous online survey was circulated PLWH attending at three services Sussex. The questionnaire covered key themes: socio-demographic characteristics; changes physical mental health; accessibility essential health information; socio-economic concerns. Free-text qualitative responses were through framework analysis. Quantitative data from 653...
Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability maintaining drug-free viral control subsequent interruptions, for reasons that remain unclear. Using samples from randomized-controlled human clinical trial evaluating therapeutic vaccines, we here show ART commencement frequently accelerated and efficient selection genome-intact proviruses in repressive chromatin locations first year after initiation. This process was...
Chemsex has been reported among men who have sex with (MSM) living HIV. There concerns about potentially harmful drug-drug interactions between chemsex drugs and antiretroviral therapy (ritonavir cobicistat). We aimed to describe the prevalence patterns of users in our HIV clinic population evaluate prescribing users.We undertook a cross-sectional study patients attending January 2019 December 2020. collected data on disclosed recent recreational drug use including previous 3 months.In all,...
Sexually transmitted enteric infections in men who have sex with (MSM) can be caused by viruses (eg, hepatitis A), bacteria Shigella ) and protozoa Giardia cause hepatitis, proctocolitis enteritis.1 Enteric MSM occur sporadic outbreaks related to sexual networks involving transmission of other STIs, geosocial app use for meeting partners chemsex (high-risk behaviour recreational drug use, including injecting use).1 2 is a Gram-negative closely Escherichia coli causing self-limiting diarrhoea...
We aim to identify associations that may help support strategies increase job satisfaction and reduce unscheduled time off work for nurses. Given current concerns regarding nursing workforce retention, it is vital we factors which maintain satisfaction, staff retention work. As part of a quality improvement project, conducted distributed an online anonymous survey. Likert scales were used measure perceived care, wellbeing, explored participation in project any kind the preceding 12 months,...
The characteristics and serological responses of primary syphilis are not completely understood. We aimed to describe the characteristics, presumptive treatment in HIV-positive -negative men who have sex with (MSM). conducted a retrospective review microbiological demographic information from MSM presenting syphilis. There were 111 cases MSM, median age was 46 (IQR = 37–53years) 40 (36%) living HIV. Fifty percent presented painful lesions 14% extra-genital lesions. Extra-genital...
Within the UK, majority of hepatitis A occurs in high risk groups such as men who have sex with (MSM). It has been estimated that 70% MSM need immunity to provide adequate herd immunity. We aimed estimate proportion susceptibility throughout a 10-year period (2010–2019), and explore associated demographic factors. Using our Electronic Patient Record system, we extracted anonymous clinical data between for at their first attendance; including IgG result, age, country birth diagnosis an STI....
We aimed to evaluate the usability and acceptability of a co-designed mobile health (mHealth) application (PrEP-EmERGE) within digital pathway support HIV pre-exposure prophylaxis (PrEP).This was cross-sectional study PrEP-EmERGE app. Data were collected via an online survey sent all PrEP EmERGE users in September 2021. Usability assessed with validated tool, System Scale (SUS). Acceptability using modified patient-reported experience measures (PREMs). Quantitative data analysed descriptive...