A5101840789- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Regional Economic and Spatial Analysis
- Biochemical and Molecular Research
- Human Mobility and Location-Based Analysis
- AI in cancer detection
- Advanced Sensor and Control Systems
- Pharmacogenetics and Drug Metabolism
- Land Use and Ecosystem Services
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Brain Tumor Detection and Classification
- Advanced Data Compression Techniques
- Regional Economics and Spatial Analysis
- Lung Cancer Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Gut microbiota and health
- Globalization, Economics, and Policies
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Imperial College London
2010-2023
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2023
NIHR Imperial Biomedical Research Centre
2023
St Stephen’s AIDS Trust
2016
Chelsea and Westminster Hospital NHS Foundation Trust
2016
St. Mary’s Hospital
2016
University of Liverpool
2016
East China Normal University
2014
Demographic data show an increasingly aging human immunodeficiency virus (HIV) population worldwide. Recent concerns over dolutegravir-related neuropsychiatric toxicity have emerged, particularly amongst older people living with HIV (PLWH). We describe the pharmacokinetics (PK) of dolutegravir (DTG) 50 mg once daily in PLWH aged 60 and older. Additionally, to address calls for prospective toxicodynamic data, we evaluated changes sleep quality cognitive functioning this after switching...
Metabolic footprinting has shown enormous potential as a phenotyping tool and we are interested in applying it to understand the physiology of opportunistic pathogen Pseudomonas aeruginosa during its chronic infection lungs cystic fibrosis patients. The selection pressures surviving CF lung environment lead genetic adaptations bacterium. A common adaptation is mutation mucAgene, resulting loss-of-function anti-sigma factor MucA, which leads mucoid phenotype consequence overproduction...
Dolutegravir (DTG) is an integrase strand transfer inhibitor, which a newly approved antiretroviral drug used for the treatment of HIV-infected naive and experienced individuals. Many aspects DTG pharmacology remain to be studied. Our aim was develop fully validate robust analytical method quantification in plasma using liquid chromatography coupled with UV detection.A simple rapid protein precipitation analyte extraction from 100 µL plasma. The separation achieved on C8 reverse-phase column...
A clinical trial showed that efavirenz 400 mg once daily (EFV400) is as effective the standard adult dose. World Health Organization recommends EFV400 an alternative first-line agent, but data are lacking in third trimester of pregnancy (TT). We investigated pharmacokinetics, efficacy, and CYP2B6 pharmacogenetics HIV-infected women (WLWH) on during TT post-partum (PP). An open-label 2-center study (United Kingdom, Uganda) was conducted WLWH receiving antiretroviral regimens containing 600...
The World Health Organization recommends efavirenz 400 mg (EFV400) as first-line antiretroviral therapy, with a disclaimer that no data anti-tuberculosis (TB) treatment exist. Many people living human immunodeficiency virus (PLWH) require TB isoniazid (INH) and rifampicin (RIF), which affect cytochrome P450 exposure. PLWH receiving tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/EFV 600 viral load (VL) <50 copies/mL switched to TDF/FTC/EFV400. Genetic polymorphisms pharmacokinetic...
Abstract Objectives Dolutegravir has replaced efavirenz as first-line treatment in universal HIV guidelines. We sought to ascertain the contributory effect of SNPs four key genes linked dolutegravir disposition (UGT1A1, ABCG2, CYP3A and NR1I2) on plasma pharmacokinetics. Methods Paired pharmacogenetic/pharmacokinetic data from 93 subjects were analysed for association using multivariate linear regression. Results Co-occurring UGT1*28 NR1I2 c.63396C&gt;T homozygosity was associated with a...
Detection of pulmonary nodules combined extraction by multi-directions PCA and identification 3D (three dimension) BP neural network is presented in the paper, which different from most lung CAD algorithms, that it does not require any a priori information human intervention but solely contained CT image itself, capable to perform full automation support radiologists their final decision. The technique tested against 60 cases are screened out cancer experts. Results confirm validity as well...
Objectives To investigate the associations of plasma lamivudine (3TC), abacavir (ABC), emtricitabine (FTC) and tenofovir (TFV) concentrations with cognitive function in a cohort treated people HIV (PWH). Methods Pharmacokinetics (PK) (Cogstate, six domains) data were obtained from PWH recruited POPPY study on either 3TC/ABC or FTC/tenofovir disoproxil fumarate (TDF)-containing regimens. Association between PK parameters (AUC 0-24 : area under concentration-time curve over 24 hours, C max...
We report outcomes and novel characterization of a unique cohort 42 individuals with persistently indeterminate human immunodeficiency virus (HIV) status, the majority whom are HIV viral controllers. Eligible had or positive serology, but undetectable ribonucleic acid (RNA) by commercial assays were not taking antiretroviral therapy (ART). Routine investigations included Western blot, load, qualitative HIV-1 deoxyribonucleic (DNA), coinfection screen, T-cell quantification. Research...
: Associations between markers of liver and renal dysfunction nucleotide reverse transcriptase inhibitor plasma exposure are ill-defined. As part a large cohort study (Pharmacokinetic Clinical Observations in People over Fifty), we analysed associations alanine aminotransferase estimated glomerular filtration rate results people living with HIV on tenofovir disoproxil fumarate, emtricitabine, abacavir lamivudine. While found no concentrations aminotransferase, lower values were associated...
Abstract Fever is the most common reason that children present to Emergency Departments in UK. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, there no definitive test for accurate diagnosis infection. As a result, many prescribed antibiotics unnecessarily, while others with life-threatening infections can remain untreated. The ‘omics’ approaches identifying biomarkers from host-response promising. In this study, lipidomic analysis was carried out plasma...
Background: Since 2017, a national referral clinical service has investigated individuals with persistently indeterminate HIV status. We report the outcomes and novel characterisation of this cohort, majority whom are viral controllers.Methods: Eligible had or positive serology, but undetectable RNA by commercial load assays were not taking antiretroviral therapy (ART). Routine investigations were: serology including Western blot; load; qualitative HIV-1 DNA assays; co-infection autoantibody...