A5083506356- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Gene expression and cancer classification
- Pediatric Hepatobiliary Diseases and Treatments
- Anorectal Disease Treatments and Outcomes
- Simulation-Based Education in Healthcare
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- GDF15 and Related Biomarkers
- Male Breast Health Studies
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Molecular Biology Techniques and Applications
- Inflammatory Bowel Disease
- Breast Lesions and Carcinomas
- Genetic factors in colorectal cancer
- Enhanced Recovery After Surgery
- Surgical Simulation and Training
- Antimicrobial Resistance in Staphylococcus
University Hospitals Birmingham NHS Foundation Trust
2021-2023
University Hospitals of Leicester NHS Trust
2014-2015
St James's University Hospital
2011-2012
University of Manchester
2011
Manchester Royal Infirmary
2008-2011
Manchester Academic Health Science Centre
2011
Pancreatic cancer is the fourth leading cause of related death. The difficulty in detecting pancreatic at an early stage, aggressiveness and lack effective therapy all contribute to high mortality. Epidermal growth factor receptor (EGFR) a transmembrane glycoprotein, which expressed normal human tissues. It member tyrosine kinase family factors receptors encoded by proto-oncogenes. Several studies have demonstrated that EGFR over-expressed cancer. Over-expression correlates with more...
Pancreatic and periampullary cancers have a high incidence of activating KRAS mutations. The aim this study was to determine the EGFR mutations in pancreatic their relationship with survival.One hundred patients undergoing pancreaticoduodenectomy or biopsy for cancer were recruited. Samples formalin-fixed paraffin-embedded fresh tissue obtained. analyzed by DNA sequencing exons 18 21. pyrosequencing codons 12, 13, 61.EGFR found 2 (2.3%) 88 assessable cases. One exon (c.1966C>T, p.Q710X) 1 19...
Abstract Postoperative recurrence [POR] after an ileocolonic resection with anastomosis is frequently encountered in patients Crohn’s disease. The 8th Scientific Workshop of ECCO reviewed the available evidence on pathophysiology and risk factors for POR. In this paper, we discuss published data role microbiome, mesentery, immune system genetic background. addition to investigating causative mechanisms POR, identification essential tailor preventive strategies. Potential clinical, surgical...
The last decade has seen significant progress in understanding the molecular biology of pancreatic adenocarcinoma. There is now an urgent need to translate these techniques clinical practice order improve diagnosis and prediction response treatment. objectives this study are utilise poly(A) RT–PCR measure expression levels diagnostic Indicator genes, selected from microarray studies, RNA intraoperatively sampled ductal juice correlate with those matched tissue resection samples....
Extralevator abdominoperineal excision for rectal cancer is associated with an increased incidence of perineal hernia. The purpose this study was to determine clinical outcome following hernia repair prosthetic mesh by a open approach.We present case series 10 patients who underwent 12 repairs their using placed technique. Patients were identified from prospectively maintained database and records retrieved along imaging analysed retrospectively.Perineal in our 10%. median age 73 ± 5.9...
There is a need to develop methods of early diagnosis for pancreatic cancer. Pancreatic juice easily collected by endoscopic retrograde cholangiopancreatography and may facilitate using molecular markers. The aim this work was explore the feasibility measurement gene expression in RNA isolated from ductal juice.Intraoperative sampling undertaken 27 patients undergoing pancreaticoduodenectomy suspected tumor. Total extracted used as template poly(adenylic acid) (poly[A]) polymerase chain...
<h3>Introduction</h3> Routine swab cultures at the time of perianal abscess drainage remains common practice in modern day emergency colorectal surgery. We aimed to analyse effectiveness culture swabs predict short term and long outcomes drainage. <h3>Method</h3> 350 consecutive patients from January 2008 December 2010 undergoing incision (I&D) abscesses with packing wound community were analysed for readmission, follow up outpatient visit, repeat procedure ongoing symptoms presence anal...