A5004489921- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Particle accelerators and beam dynamics
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Particle Accelerators and Free-Electron Lasers
- Radiation Effects in Electronics
- Particle Detector Development and Performance
- Superconducting Materials and Applications
- Atomic and Subatomic Physics Research
- Boron Compounds in Chemistry
- Muon and positron interactions and applications
- Dark Matter and Cosmic Phenomena
- Atomic and Molecular Physics
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced MRI Techniques and Applications
- Particle physics theoretical and experimental studies
- Ultrasound and Hyperthermia Applications
- Graphite, nuclear technology, radiation studies
- Advanced DC-DC Converters
- Gyrotron and Vacuum Electronics Research
- CCD and CMOS Imaging Sensors
- Neuroblastoma Research and Treatments
- Spacecraft and Cryogenic Technologies
- Advanced X-ray Imaging Techniques
National Center for Oncological Hadrontherapy
2015-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Pavia
2024
Université de Strasbourg
2024
University of Pavia
2024
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
2024
Science and Technology Facilities Council
2024
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
1993-2023
Universitat de Barcelona
2023
University of Salento
2023
Polytechnic University of Bari
2023
The Superconducting Ion Gantry (SIG) project is the contribution from INFN (the Italian National Institute for Nuclear Physics) to international SIGRUM with aim of exploring new technological solutions critical elements a 430 MeV/u carbon ion gantry. includes design and construction cos <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\theta$</tex-math></inline-formula> 4 T superconducting dipole...
Next generation ion therapy magnets both for gantry and accelerator (synchrotron) are under investigation in a recently launched European collaboration that, the frame of H2020 HITRI <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">plus</i> I.FAST programmes, has obtained some funding work packages on superconducting magnets. Design technology will be developed synchrotron -especially- gantry, taking as reference beams 430 MeV/nucleon ions...
In the framework of <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">euro</i> SIG project and within an international collaboration between CNAO, CERN, INFN, MedAustron, design a novel gantry for hadron therapy based on superconducting magnets downstream scanning system has been undertaken. The choice placing last dipole plays crucial role in overall layout gantry, having direct impact its radius, weight, cost. proposed considers two separate...
Abstract Various initiatives in Europe have been launched to study superconducting magnets for a rotatable gantry suitable deliver up 440 MeV/A carbon ions hadron therapy. One initiative is led by INFN inside an agreement with CERN, CNAO, and MedAustron aiming at designing manufacturing strongly curved cos θ dipole rated 4 T central field ramp rate of 0.15-0.4 T/s. Here we explore the suitability technology derived from HEP collider that poses severe conditions on thermal design (indirectly...
Introduction: Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies, calling for enhanced research. ductal adenocarcinoma (PDAC) represents 70–80% all cases known its resistance to conventional therapies. Carbon-ion radiotherapy (CIRT) has emerged as a promising approach due ability deliver highly localized doses unique radiobiological properties compared X-rays. In vitro radiobiology relied on two-dimensional (2D) cell culture models so far; however, these are not...
Abstract FOOT (FragmentatiOn Of Target) is a nuclear physics experiment currently under construction that will measure differential cross sections for the production of secondary fragments induced by interactions proton and ion beams, up to 400 MeV/u, with human tissues. By extending energy range about 800 also provide data useful radio-protection in space, as understanding fragmentation processes take place spacecraft shieldings crucial their optimisation. The collaboration building...
Hadrontherapy utilizes accelerated ion beams to deliver precise and effective cancer treatments, depositing energy at specific depths while sparing healthy tissues. Gantries are large rotating structures that direct various angles around the patient, improving dose conformity tumors robustness of treatment plan minimizing radiation exposure surrounding organs. While proton gantries widespread commercially available, diffusion carbon is limited due more demanding technological challenges...
Abstract Ion beam therapy effectively treats radiation-resistant and deeply located tumors but requires meticulous planning wide safety margins imposed by current technology. Proton transmission imaging, using protons instead of x-rays for image acquisition, is pivotal precise treatment directly probing the proton stopping power, reducing uncertainties, enabling a fast verification treatment. In last 15 years, imaging prototypes have primarily used calorimeter detectors. An alternative...
Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET)...
Abstract The Heavy Ion Therapy Research Integration plus (HITRIplus) is an European project that aims to integrate and propel research technologies related cancer treatment with heavy ion beams. Among the ambitious goals of project, a specific work package includes design gantry for carbon ions, based on superconducting magnets. first milestone achieve choice fundamental parameters, namely beam optics layout, magnet technology, main user requirements. Starting from reference 3 T design,...
Abstract The design of smaller and less costly gantries for carbon ion particle therapy represents a major challenge to the diffusion this treatment. Here we present work done on linear beam optics possible gantry layouts, differing geometry, momentum acceptance, magnet technology, which share use combined function superconducting magnets with bending field 4 T. We performed parallel– to–point point–to–point matching at different magnification factors provide two sizes isocenter. Moreover,...
Primary mucosal melanoma (PMM) and pancreatic ductal adenocarcinoma (PDAC) are two aggressive malignancies, characterized by intrinsic radio-chemoresistance neurotropism, a histological feature resulting in frequent perineural invasion (PNI), supported neurotrophic factors secreted the tumour microenvironment (TME), such as neurotrophin-3 (NT-3). Carbon-ion radiotherapy (CIRT) could represent an effective option unresectable PMM PDAC. Only few data about effects of CIRT on PNI relation to...
The Superconducting Ion Gantry (SIG) project aims to design, construct, and test a curved superconducting dipole demonstrator magnet for an ion gantry (up rigidity of 6.6 Tm). main parameters are dipolar field 4 T generated into toroidal aperture with 80 mm diameter, 1.65 m curvature radius, 30° angular sector. is inserted in the framework <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">EuroSIG</i> collaboration among CNAO, CERN, INFN,...
Introduction: Decellularized extracellular matrix (ECM) bioscaffolds have emerged as a promising three-dimensional (3D) model, but so far there are no data concerning their use in radiobiological studies. Material and Methods: We seeded two well-known radioresistant cell lines (HMV-II PANC-1) decellularized porcine liver-derived scaffolds irradiated them with both high- (Carbon Ions) low- (Photons) Linear Energy Transfer (LET) radiation order to test whether natural 3D-bioscaffold might be...
FAMU is an INFN-led muonic atom physics experiment based at the RIKEN-RAL muon facility ISIS Neutron and Muon Source (United Kingdom). The aim of to measure hyperfine splitting in hydrogen determine value proton Zemach radius with accuracy better than 1%. has a scintillating-fibre hodoscope for beam monitoring data normalisation. In order carry out flux estimation, low-rate measurements were performed extract single-muon average deposited charge. Then, detector simulation Geant4 FLUKA...
Primary gynecological melanomas are uncommon with lower survival rates compared to cutaneous melanomas. Although melanocytes have been identified in a variety of mucosal membranes, little is known about their interactions or roles inside the mucosa layer. Melanin common pigment nature and endowed several peculiar chemical, paramagnetic, semiconductive characteristics. One its latest explored functions interaction ionizing radiation as protective mechanism well implication metastatic cascade...
A collaboration between CERN, CNAO, INFN, and MedAustron has been formed aiming at designing a light rotating gantry suitable for hadron therapy based on 430 MeV/n carbon ion beams. After first design 3 T dipole field, as the backbone of magnetic system, now is looking an alternative design, least 4 field with faster ramp rate. The magnet designed according to cosθ layout be wound Nb-Ti superconducting Rutherford cable. One main challenges very small curvature radius 1.65 m relatively large...