A5081480910- Cervical Cancer and HPV Research
- Pregnancy and preeclampsia studies
- Genital Health and Disease
- Reproductive tract infections research
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Gestational Diabetes Research and Management
- Genomic variations and chromosomal abnormalities
- Urological Disorders and Treatments
- Maternal and fetal healthcare
- BRCA gene mutations in cancer
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Neonatal and fetal brain pathology
- Systemic Sclerosis and Related Diseases
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Growth Hormone and Insulin-like Growth Factors
- Head and Neck Cancer Studies
- Molecular Biology Techniques and Applications
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Infectious Encephalopathies and Encephalitis
Policlinico San Matteo Fondazione
2009-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2024
University of Pavia
2004-2024
Foundation Center
2019
University of Siena
1995
Abstract A large proportion of human papillomavirus (HPV) infections is sustained by multiple genotypes. The effect on the risk cervical intraepithelial neoplasia (CIN) and potential efficacy vaccine these are controversial. We performed viral typing SFP 10 ‐LIPA a consecutive series 1,323 women undergoing colposcopy, 69% whom had biopsy, correlated CIN severity with type number HPVs. Overall prevalence HPV‐DNA was 68.9%, 97.3% in CIN1, 98.1% CIN≥2. HPV positivity younger age (35.9 vs. 37.3...
The purpose of the study was to evaluate differences in individual histopathologic placental lesions pregnancies complicated by early-onset (<32 weeks at diagnosis) and late-onset (≥32 fetal growth restriction (FGR).A cohort 440 singleton FGR, diagnosed according standard ultrasonographic criteria, followed up delivered same institution between 2010 2016. Placental were classified Amsterdam Workshop Consensus Criteria. Pathologic examination placentas from 113 healthy term served as...
Introduction: Decellularized extracellular matrix (ECM) bioscaffolds have emerged as a promising three-dimensional (3D) model, but so far there are no data concerning their use in radiobiological studies. Material and Methods: We seeded two well-known radioresistant cell lines (HMV-II PANC-1) decellularized porcine liver-derived scaffolds irradiated them with both high- (Carbon Ions) low- (Photons) Linear Energy Transfer (LET) radiation order to test whether natural 3D-bioscaffold might be...
Traditional approaches for the classification of Small Supernumerary Marker Chromosomes (sSMC), mostly based on FISH techniques, are time-consuming and not always sufficient to fully understand true complexity this class rearrangements. We describe four supernumerary marker chromosomes that, after array-CGH, were interpreted rather differently in respect early made by conventional cytogenetics investigations, reporting two types complex markers which DNA content was overlooked approaches: 1....
ABSTRACT Lower levels of performance human papillomavirus (HPV) typing assays in studies using formalin-fixed paraffin-embedded (FFPE) tissue compared to those exfoliated cervical cells have been reported. The interpretation current is limited by bias inclusion criteria, sample matching, and methods cell collection. We aimed validate FFPE for the use SPF 10 LiPA assay, comparing scrapings punch cone biopsy specimens. examined 165 paired scraping samples, 66 samples. HPV was performed assay....
The aim is to evaluate the clinical consequences of coinfection between HPV 16 and other high-risk HPVs among women with a histological diagnosis CIN or invasive cervical cancer. A total 2985 women, either cancer (<IB) on cone biopsy, were included. genotypes identified using INNO-LiPA genotyping assay, version EXTRA, scraping, before colposcopic evaluation biopsies conization. In overall population, HPV16 interacted positively HPV18 (RR = 2, 95% CI 1.5-2.6) negatively HPV33, 51, 52, 66, in...
The aim of the study was to evaluate association between size cervical lesions as detected by colposcopy and multiple human papillomavirus (HPV) infection in subjects with intraepithelial neoplasia (CIN).A case series 898 CIN diagnosed histopathology infected high-risk HPV. Human genotypes were identified using INNO-LIPA genotyping system.The rates 1, 2, 3+ 53.1% (477/898), 14.1% (127/898), 32.7% (294/898), respectively. Among loop electrosurgical excision procedure or cold-knife conization,...
<b><i>Objectives:</i></b> The main risk factor involved in CIN2+ recurrence after treatment is the HPV persistent infection. dysregulation of immune system permits only HR-HPVs to become infections, promote cancer development, and increase treatment. Therefore, there a shift Th2-type cytokine pattern during carcinogenesis pathway; for this reason, neutrophil-lymphocytes ratio (NLR) could be marker immunological change. study aimed analyse predictive role NLR...
Abstract Objective The objective of the study was to evaluate rates pathological placental lesions among pregnant subjects positive for aPL antibodies. Methods We performed a longitudinal case–control including 27 with primary APS, 51 non-criteria 24 antibodies associated other well-known CTDs enrolled at end first trimester pregnancy and 107 healthy controls. Results Compared controls after correction multiple comparisons, primary, APS CTD, had lower weight, volume area. After penalized...
The aim of the study was to evaluate outcome persistent (≥2 years) low-grade cervical intraepithelial neoplasia (CIN 1) treated with loop electrosurgical excision procedure (LEEP).A 252 subjects biopsy-confirmed CIN 1 diagnosed after squamous lesions or atypical undetermined significance on Papanicolaou test and LEEP. Post-LEEP follow-up cytological, colposcopic, molecular diagnostic examinations were scheduled at 6 months, year, yearly thereafter.The enrolled had a total number 1,008 visits...
Background: Low-grade cervical lesions have a high percentage of clearance in young women, even if 71–82% low-grade intraepithelial lesion/atypical squamous cells undetermined significance (LSIL/ASCUS) reported High-Risk Human Papillomavirus (HR-HPV) infection, which correlates with an increased risk Cervical Intraepithelial Neoplasia (CIN)2+. The immunogenic effect the anti-HPV vaccine appears to be significant. aim study is evaluate effect, two years after diagnosis, preventive vaccination...