A5091724441- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Radiation Effects and Dosimetry
- Radiation Dose and Imaging
- Radioactive contamination and transfer
- Advanced MRI Techniques and Applications
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Radioactivity and Radon Measurements
- Radioactive element chemistry and processing
- Luminescence Properties of Advanced Materials
- Glass properties and applications
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Ultrasound and Hyperthermia Applications
- Advanced Optical Sensing Technologies
- Lanthanide and Transition Metal Complexes
- Spectroscopy and Laser Applications
- Boron Compounds in Chemistry
- Quality and Safety in Healthcare
- Nuclear and radioactivity studies
- Nuclear materials and radiation effects
- Analytical Chemistry and Sensors
- Conservation Techniques and Studies
University of Milan
2015-2024
Istituto Nazionale di Fisica Nucleare
2010-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2011-2023
National Interuniversity Consortium of Materials Science and Technology
2019-2022
University of Palermo
2016
IRCCS Ospedale San Raffaele
2013
Assocomaplast
2007
National University of Singapore
2007
Abstract Background A multidisciplinary and multi-institutional working group applied the Failure Mode Effects Analysis (FMEA) approach to actively scanned proton beam radiotherapy process implemented at CNAO (Centro Nazionale di Adroterapia Oncologica), aiming preventing accidental exposures patient. Methods FMEA was treatment planning stage consisted of three steps: i) identification involved sub-processes; ii) ranking potential failure modes, together with their causes effects, using risk...
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0-2 Gy ions 0-7 6 MV photons. Hyperthermia realized via standard heating bath, assisted by magnetic fluid (MFH) that utilizes nanoparticles (MNPs) exposed to an alternating field amplitude 19.5 mTesla frequency 109.8 kHz. Starting from 37 °C, temperature gradually increased sample kept at 42 °C 30...
An innovative double network hydrogel based on poly(vinyl-alcohol) (PVA) cross-linked with glutaraldehyde (GTA) was obtained by the addition of self-assembling phenylalanine (Phe) derivatives aim to achieve improved mechanical-elastic properties exploitable produce 3D dosimeters. The ability in fibrous structures Phe (FmocPhe-OH, A; FmocPhe-Phe-OMe, P) even within PVA gel proved AFM and SEM imaging. proposed matrices containing A P were completely characterized from physical-chemical point...
The aim of this paper was the application failure mode and effects analysis (FMEA) approach to assess risks for patients undergoing radiotherapy treatments performed by means a helical tomotherapy unit. FMEA applied preplanning imaging, volume determination, treatment planning stages process consisted three steps: 1) identification involved subprocesses; 2) ranking potential modes, together with their causes effects, using risk probability number (RPN) scoring system; 3) additional safety...
A multidisciplinary and multi-institutional working group applied the Failure Mode Effects Analysis (FMEA) approach to assess risks for patients undergoing Stereotactic Body Radiation Therapy (SBRT) treatments lesions located in spine liver two CyberKnife® Centres. The various sub-processes characterizing SBRT treatment were identified generate process trees of both planning delivery phases. This analysis drove identification subsequent scoring potential failure modes, together with their...
Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research emergency response mutual assistance in biodosimetry within EU. Within this extremely active network, number new dosimetry methods have recently been proposed or developed. There requirement to test and/or validate these candidate techniques inter-comparison exercises are well-established method such validation.Materials methods: The authors present details...
Quality assurance procedures required in the modern radiotherapy would greatly benefit by development of tissue equivalent dosimeters able rendering 3D dose profiles with high spatial resolution.In this scenario, Fricke gel (FG) could be good candidates, but some limitations have restricted their interest clinical practice.Recently, formulations based on matrices poly(vinyl-alcohol) (PVA) chemically crosslinked glutaraldehyde (GTA) shown improvements as compared to FGs natural...
Abstract A double network hydrogel based on Poly(vinyl-alcohol) (PVA) cross-linked with Glutaraldehyde (GTA) was recently developed by using self-assembling phenylalanine (Phe) peptide derivative (Fmoc-Phe-Phe-OMe), the aim to improve mechanical-elastic properties of PVA-GTA hydrogels. In this study, a characterization Xylenol Orange Fricke gel dosimeters obtained infusing solution into performed. The were irradiated 6 MV and 15 X -rays produced medical linear accelerator investigated means...
Over the years, many efforts have been made to develop radiation detectors handle complex issues of small field dosimetry and achieve increasing accuracy, precision in vivo dose monitoring required by new advanced treatment modalities. In this context, interest has surged development sensors based on scintillating optical fibres. paper, near-infrared radioluminescence dosimetric properties Yb-doped silica fibres, coupled with a laboratory prototype an avalanche photodiode, were studied...
The development of Fricke gel (FG) dosimeters based on poly(vinyl alcohol) (PVA) as the gelling agent and glutaraldehyde (GTA) cross-linker has enabled significant improvements in dose response stability over time spatial radiation distributions. However, a standard procedure for preparing FG terms reagent concentrations is still missing literature. This study aims to investigate, by means spectrophotometric analyses, how sensitivity range linearity dose-response curve PVA-GTA-FG loaded with...
Biological and physical retrospective dosimetry are recognised as key techniques to provide individual estimates of dose following unplanned exposures ionising radiation. Whilst there has been a relatively large amount recent development in the biological procedures, statistical analysis failed keep pace. The aim this paper is review current state art uncertainty across 'EURADOS Working Group 10-Retrospective dosimetry' members, give concrete examples implementation recommended international...
Radio-luminescence (RL) optical fiber sensors enable a remote, punctual, and real time detection of ionizing radiation. However, the employment such systems for monitoring extended radiation fields with energies above Cerenkov threshold is still challenging, since spurious luminescence, namely, “stem effect,” also generated in passive portion exposed to Here, we present experimental measurements on Yb-doped silica fibers irradiated photon different sizes. The results demonstrate that RL...
We present an investigation of the effects on BxPC3 pancreatic cancer cells proton therapy combined with hyperthermia, assisted by magnetic fluid hyperthermia performed use nanoparticles. The cells’ response to treatment has been evaluated means clonogenic survival assay and estimation DNA Double Strand Breaks (DSBs). Reactive Oxygen Species (ROS) production, tumor cell invasion cycle variations have also studied. experimental results shown that combination therapy, MNPs administration gives...