Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) great potential for periodontal disease treatment, thanks to their ability be liquid at room temperature and become viscous body temperature. However, some problems, related short situ residence time, reduce feasible clinical use. Thus, order improve effective applicability these materials, we studied...

Abstract A double network hydrogel based on Poly(vinyl-alcohol) (PVA) cross-linked with Glutaraldehyde (GTA) was recently developed by using self-assembling phenylalanine (Phe) peptide derivative (Fmoc-Phe-Phe-OMe), the aim to improve mechanical-elastic properties of PVA-GTA hydrogels. In this study, a characterization Xylenol Orange Fricke gel dosimeters obtained infusing solution into performed. The were irradiated 6 MV and 15 X -rays produced medical linear accelerator investigated means...

The synthesis of cyclohepta[b]indole derivatives through the dearomative (4 + 3) cycloaddition reaction 2-vinylindoles or 4H-furo[3,2-b]indoles with in situ generated oxyallyl cations is reported. Oxyallyl are from α-bromoketones presence a base and perfluorinated solvent. Cyclohepta[b]indole scaffolds obtained under mild conditions, absence expensive catalysts, starting simple reagents, good to excellent yields complete diasteroselectivity. Preliminary expansion scope 3-vinylindoles aza-oxyallyl

The development of Fricke gel (FG) dosimeters based on poly(vinyl alcohol) (PVA) as the gelling agent and glutaraldehyde (GTA) cross-linker has enabled significant improvements in dose response stability over time spatial radiation distributions. However, a standard procedure for preparing FG terms reagent concentrations is still missing literature. This study aims to investigate, by means spectrophotometric analyses, how sensitivity range linearity dose-response curve PVA-GTA-FG loaded with...

A [copper(I)pyridine-containing ligand]-catalyzed reaction between 2-vinylindoles and diazo esters is described. The allows for the synthesis of a series 2-vinylcyclopropa[b]indolines with excellent levels regio- sterocontrol under mild conditions.

Merging the ability of cationic gold(I) catalysts to activate unsaturated π-systems with electrophiles-driven ring-opening reactions furans, we describe a new approach synthesize 2-spiroindolin-3-ones from 4H-furo[3,2-b]indoles. The reaction occurs through cascade sequence involving addition gold-activated allene furan moiety starting furoindole followed by ring-opening/ring-closing event affording 2-spirocyclopentane-1,2-dihydro-3H-indolin-3-ones in moderate good yields.

A redox umpolung strategy for the synthesis of complex tetrahydrocarbazoles is reported.

Abstract We present a method for the synthesis of substituted indolo[1,2‐ ]quinoline‐5(6 H )‐ones starting from 1‐(2‐ethynylphenyl)‐1 ‐indoles. The transformation involves gold‐catalyzed oxidation triple bond followed by acid‐promoted intramolecular cyclization at indole C2 position. Demonstrating noteworthy versatility, reaction tolerates wide array substituents on core and proceeds in good to excellent yields (up 93 %).

Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms. However, commercially available products a low residual activity, with the consequent need multiple applications that inevitably increase costs risk of resistance phenomena insurgence. Smart delivery systems made hydrogels proved their efficacy in increasing action duration biolarvicides up to several months, but lack an efficient baiting mechanism strongly...

Abstract We describe an alternative and more sustainable method for the synthesis of 2,2’‐disubstituted 3,3’‐biindoles starting from 2,2’‐diaminotolanes (hetero)arylaldehydes. The key feature approach is use acidic Deep Eutectic Solvent (DES) able to exploit a double activity, i. e., solvent Brønsted Acid (BA) catalyst, avoiding Volatile Organic Compounds (VOCs) as solvents additional acid catalysts. By this way, we synthesized twenty‐five biindoles, including eighteen new compounds....

Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐ a ]indol‐6(7 H )‐ones starting from N ‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves cascade addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric indole‐fused 1,4‐diazepinones characterized N−C(aryl) axial chirality in yields ranging 51 to 99%.

Self‐assembled peptides are used for diverse applications in the biomedical and technological fields. The morphology function of assembled systems dictated by peptide sequence length. In this work, a supramolecular catalyst was obtained upon self‐assembly diphenylalanine conjugated to triphenylphosphine Au(I) complex acetonitrile. molecules were characterized spectroscopic techniques scanning electron microscopy. activity tested on two substrates cyclization reactions. dimensions vary...

2-Trienyliden-indolin-3-ones were synthesised in high yields <italic>via</italic> a gold catalysed cascade reaction between 4<italic>H</italic>-furo[3,2-<italic>b</italic>]indoles and propargyl esters.

In this paper, we describe the synthesis of neglected 1‐aminoisochromene derivatives starting from 2‐alkynylbenzaldehydes and electron‐poor anilines. The domino reaction is catalyzed by original [Ag I PcL] complexes occurs with complete regioselectivity under mild conditions. approach well‐tolerates different aryl, heteroaryl, alkyl cycloalkyl substituents on alkyne terminus to give desired products in modest very good yields.

Abstract The development of alternative benign reaction conditions to perform multicomponent reactions is an interesting and desirable strategy increase the sustainability organic synthesis. In this paper, we report a new version A 3 ‐coupling MCR for preparation differently substituted propargylamines starting from aldehydes, alkynes amines in acidic DES as media, under dielectric heating, presence tetraaza‐macrocyclic silver complex catalyst. scope broad terms aldehyde partners....

The reactivity of vinyl‐/furoindole derivatives with gold‐activated π‐systems is the subject extensive investigation. In presence these electrophilic partners, realized transformations allow for construction different and fascinating architectures via cycloaddition cyclization reactions often included in cascade processes. involving processes an external substituent at indole moiety are present minireview.

Abstract A highly reactive and selective catalytic system comprising Cu(I) a macrocyclic pyridine‐containing ligand (Pc−L) for the synthesis of 2‐(penta‐2,4‐dien‐1‐ylidene) 3‐oxoindolines from 4 H ‐furo[3,2‐ b ]indoles diazoalkane is reported herein. The reaction sequence involves initial formation copper‐carbene by Cu(I)‐catalyzed decomposition followed to furoindole addition successive furan ring‐opening affording final products. proved be quite general, tolerating EWG as well EDG...

A simple and efficient approach for the synthesis of 2-spirocyclopropyl-indolin-3-ones is herein described.

Gold runs into the light. A cooperative catalytic approach to unprecedented 3,4 hetero-disubstituted isocoumarins.

The Cover Feature shows the synthesis of substituted indolo[1,2-a]quinoline-5(6H)-ones starting from 1-(2-ethynylphenyl)-1H-indoles and N-oxides by a gold-catalyzed oxidation triple bond, followed an acid-promoted intramolecular cyclization at indole C-2 position. More information can be found in Research Article E. Brambilla, V. Pirovano co-workers (DOI: 10.1002/ejoc.202400083). design Dominica Del Grosso.

In this study, we explored and optimized a MW-enhanced divergent approach for the synthesis of 2-substituted benzofurans chromenes, starting from seventeen substituted