A5008278469- Diamond and Carbon-based Materials Research
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Radiotherapy Techniques
- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Graphene research and applications
- Force Microscopy Techniques and Applications
- Semiconductor materials and devices
- Metal and Thin Film Mechanics
- Ion-surface interactions and analysis
- Advanced Sensor and Energy Harvesting Materials
- Carbon Nanotubes in Composites
- Fullerene Chemistry and Applications
- Neuroscience and Neural Engineering
- Hydrogels: synthesis, properties, applications
- Radiation Therapy and Dosimetry
- Catalytic Processes in Materials Science
- Polymer Surface Interaction Studies
- Electrocatalysts for Energy Conversion
- Tissue Engineering and Regenerative Medicine
- Radiomics and Machine Learning in Medical Imaging
- Microfluidic and Bio-sensing Technologies
- Pancreatic function and diabetes
- Boron and Carbon Nanomaterials Research
University of Milan
2015-2024
Istituto Nazionale di Fisica Nucleare
2019-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2017-2023
Interface (United States)
2019-2023
Mylan (South Africa)
2018-2020
Mylan (Switzerland)
2016-2020
Fondazione Filarete
2009-2018
National Interuniversity Consortium of Materials Science and Technology
2017
European School of Molecular Medicine
2015
National Research Council
2015
Bacterial infection of implants and prosthetic devices is one the most common causes implant failure. The nanostructured surface biocompatible materials strongly influences adhesion proliferation mammalian cells on solid substrates. observation this phenomenon has led to an increased effort develop new strategies prevent bacterial biofilm formation, primarily through nanoengineering topology used in implantable devices. While several studies have demonstrated influence nanoscale morphology...
Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range medical and industrial applications. However toxicity AgNPs impact their physicochemical characteristics in vivo models still need to be comprehensively characterized. The aim this study was investigate the effect size coating on tissue distribution after intravenous administration mice, compare results with those obtained silver acetate administration. Male CD-1(ICR) mice were...
Nanostructured carbon films produced by supersonic cluster beam deposition have been studied in situ Raman spectroscopy. spectra show the formation of a sp2 solid with very large fraction sp-coordinated carbyne species long-term stability under ultrahigh vacuum. Distinct contributions from polyyne and cumulene observed, as well different stabilities gas exposure. Our experiments confirm theoretical predictions demonstrate possibility producing carbyne-rich pure solid. The sp2-sp network has...
We report the direct observation of solidlike ordering at room temperature thin films [Bmim][NTf2] ionic liquid on mica, amorphous silica, and oxidized Si(110). A statistical quantitative analysis atomic force microscopy topographies shows that these surfaces forms layered structures, characterized by a perpendicular structural periodicity approximately 0.6 nm. Remarkably, even highest up to 50 nm high, behave against AFM probe. Conversely, highly oriented pyrolitic graphite nanometer-sized,...
Electroactive ionic gel/metal nanocomposites are produced by implanting supersonically accelerated neutral gold nanoparticles into a novel chemically crosslinked ion conductive soft polymer. The gel consists of poly(acrylic acid) and polyacrylonitrile networks, blended with halloysite nanoclays imidazolium-based liquid. material exhibits mechanical properties similar to that elastomers (Young's modulus ≈ 0.35 MPa) together high conductivity. fabrication thin (≈100 nm thick) nanostructured...
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) great potential for periodontal disease treatment, thanks to their ability be liquid at room temperature and become viscous body temperature. However, some problems, related short situ residence time, reduce feasible clinical use. Thus, order improve effective applicability these materials, we studied...
Nanostructured carbon films consisting of sp chains (polyynes and polycumulenes) embedded in an ${\mathrm{sp}}^{2}$ matrix are grown using supersonic cluster beam deposition ultrahigh vacuum at room temperature. All the specimens have been analyzed by situ Raman spectroscopy. The use different excitation wavelengths (532 632.8 nm) confirms presence distinct carbynoid species. Chemical stability species has studied exposing as-deposited to 500 mbar ${\mathrm{H}}_{2},$ He, ${\mathrm{N}}_{2},$...
We report the production and characterization of a form amorphous carbon films with sp/sp2 hybridization (atomic fraction sp hybridized species > 20%) where predominant bonding appears to be (=C=C=)n cumulene. Vibrational electronic properties have been studied by in situ Raman spectroscopy electrical conductivity measurements. Cumulenic chains are substantially stable for temperatures lower than 250 K they influence transport through self-doping mechanism pinning Fermi level closer one...
Background: Microneedle-mediated drug delivery is a promising method for transdermal of insulin, incretin mimetics, and other protein-based pharmacologic agents treatment diabetes mellitus. One factor that has limited clinical application conventional microneedle technology the poor fracture behavior microneedles are created using materials methods. In this study polymer were two-photon polymerization (2PP) microfabrication subsequent polydimethylsiloxane (PDMS) micromolding process....
Thanks to mechanotransductive components cells are competent perceive nanoscale topographical features of their environment and convert the immanent information into corresponding physiological responses. Due its complex configuration, unraveling role extracellular matrix is particularly challenging. Cell substrates with simplified cues, fabricated by top-down micro- nanofabrication approaches, have been useful in order identify basic principles. However, underlying molecular mechanisms this...
We report on the fabrication and electro-mechanical characterization of a nanocomposite system exhibiting anisotropic electrical response under application tactile compressive stresses (5 kPa) at low frequencies (0.1-1 Hz). The is based chemically cross-linked gel incorporating highly conductive ionic liquid surface functionalized barium titanate (BaTiO3) ferroelectric nanoparticles. was engineered to respond mechanical stimulations by combining piezoionic piezoelectric activity, generating...
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0-2 Gy ions 0-7 6 MV photons. Hyperthermia realized via standard heating bath, assisted by magnetic fluid (MFH) that utilizes nanoparticles (MNPs) exposed to an alternating field amplitude 19.5 mTesla frequency 109.8 kHz. Starting from 37 °C, temperature gradually increased sample kept at 42 °C 30...
Subnanometer copper tetramer–zirconia catalysts turn out to be highly efficient for CO2 hydrogenation and its conversion methane. The cluster size substrate morphology are controlled optimize the catalytic performance. two types of zirconia supports investigated prepared by atomic layer deposition (∼3 nm thick film) supersonic beam (nanostructured film, ∼100 thick). plays a crucial role in determining activity catalyst as well cyclability over repeated thermal ramps. A temperature-programmed...
An innovative double network hydrogel based on poly(vinyl-alcohol) (PVA) cross-linked with glutaraldehyde (GTA) was obtained by the addition of self-assembling phenylalanine (Phe) derivatives aim to achieve improved mechanical-elastic properties exploitable produce 3D dosimeters. The ability in fibrous structures Phe (FmocPhe-OH, A; FmocPhe-Phe-OMe, P) even within PVA gel proved AFM and SEM imaging. proposed matrices containing A P were completely characterized from physical-chemical point...
Amorphous and nanostructured carbon films were grown by using two different techniques: ion sputtering cluster beam deposition. The studied near-edge x-ray absorption fine structure (NEXAFS) Raman spectroscopy. Depending on the precursors, atoms, or clusters, are characterized a sp2/sp3 ratio which influences mechanical electronic properties. Due to sensitivities of NEXAFS (local order) (medium-range order), we have compared over length scales. complementarity techniques for characterization...
Carbon nitride films (CNx) have been deposited by sputtering a graphite target with nitrogen ions. Films were grown both and without the presence of an assisting focused N2 ion beam. The sputter beam voltage was varied between 150 1500 V applied from 80 to 500 V. substrate held at fixed temperatures 673 K. coatings characterized respect their electrical, optical, structural properties. content measured x-ray photoelectron spectroscopy (XPS) maximum concentration 44 at. % obtained for...
Amorphous carbon films with $sp\text{\ensuremath{-}}s{p}^{2}$ hybridization, produced by supersonic cluster beam deposition, shows the presence of both polyynic and cumulenic species [L. Ravagnan et al., Phys. Rev. Lett. 98, 216103 (2007)]. Here, we present an in situ Raman characterization low-frequency vibrational region $(400--800\text{ }{\text{cm}}^{\ensuremath{-}1})$ at different temperatures. We report two peaks 450 $720\text{ }{\text{cm}}^{\ensuremath{-}1}$. The lower frequency peak...
Nucleus pulposus (NP) tissue damage can induce detrimental mechanical stresses and strains on the intervertebral disc, leading to disc degeneration. This study demonstrates potential of a novel, photo-curable, injectable, synthetic polymer hydrogel (pHEMA-co-APMA grafted with polyamidoamine (PAA)) encapsulate differentiate human mesenchymal stem cells (hMSC) towards NP phenotype under hypoxic conditions which could be used restore function properties. Encapsulated hMSC cultured in media...
A remarkable composition-dependent chemical ordering in Au<sub>x</sub>Ag<sub>1−x</sub> nanoparticles is unravelled experimentally and explained by a four-step growth mechanism.