A5014145933- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- Radiation Therapy and Dosimetry
- Renal and related cancers
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Effects of Radiation Exposure
- Plant Genetic and Mutation Studies
- Carcinogens and Genotoxicity Assessment
- Mitochondrial Function and Pathology
- PARP inhibition in cancer therapy
- Prostate Cancer Diagnosis and Treatment
- Organ Donation and Transplantation
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Genital Health and Disease
Roma Tre University
2015-2024
University of Chieti-Pescara
2004-2024
Agenzia Sanitaria Regionale Abruzzo
2016-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2023
Fondazione Santa Lucia
2021-2022
Ospedale SS. Annunziata
2018-2022
Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre
2010-2021
Marconi University
2016-2021
Bassano Bresciano Astronomical Observatory
2020
Ospedale San Luigi Gonzaga
2020
Keeping Cancer Cells At Bay cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes the tumorigenic phenotype is not clear. Senovilla et al. (p. 1678 ; see Perspective by Zanetti and Mahadevan ) found tetraploidization cancer can cause them become immunogenic thus aid in their clearance from body immune system. with excess chromosomes put stress on endoplasmic reticulum, which leads movement protein calreticulin cell surface....
Background Telomeres are potential markers of mitotic cellular age and associated with physical ageing process. Long-term endurance training higher aerobic exercise capacity (VO2max) improved survival, dynamic effects evident ageing. However, the association telomere length VO2max has so far been inconsistent. Our aim was to assess whether muscle is in younger older people. Methods Twenty men; 10 young (22–27 years) old (66–77 years), were studied this cross-sectional study. Five out adults...
Ferroptosis is an iron-dependent cell death caused by impaired glutathione metabolism, lipid peroxidation and mitochondrial failure. Emerging evidences report a role for ferroptosis in Friedreich's Ataxia (FRDA), neurodegenerative disease the decreased expression of protein frataxin. Nrf2 signalling implicated many molecular aspects ferroptosis, upstream regulating homeostasis, function metabolism. As down-regulated FRDA, targeting Nrf2-mediated FRDA may be attractive option to counteract...
Ring chromosome 17 syndrome is a rare disease that arises from the breakage and reunion of short long arms 17. Usually this abnormality results in deletion genetic material, which explains clinical features syndrome. Moreover, similar phenotypic have been observed cases with complete or partial loss telomeric repeats conservation euchromatic regions. We studied two different ring syndrome, firstly, to clarify, by analyzing gene expression analysis using real-time qPCR, role telomere absence...
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0-2 Gy ions 0-7 6 MV photons. Hyperthermia realized via standard heating bath, assisted by magnetic fluid (MFH) that utilizes nanoparticles (MNPs) exposed to an alternating field amplitude 19.5 mTesla frequency 109.8 kHz. Starting from 37 °C, temperature gradually increased sample kept at 42 °C 30...
Aim:To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time.Methods: Seminological six male healthy mountain trekkers were evaluated in normoxia at sea level.After 26 days exposure to altitude (ranging from 2 000 m 5 600 m, Karakorum Expedition) same again after returning level.These once 1 month then 6 months.Results: Sperm count was found be lower immediately level (P = 0.0004) a 0.0008).Normal levels reached months.Spermatic motility (%) shows...
Most human tumors maintain telomere lengths by telomerase, whereas a portion of them (10–15%) uses mechanism named alternative lengthening telomeres (ALT). The telomeric G-quadruplex (G4) ligand RHPS4 is known for its potent antiproliferative effect, as shown in telomerase-positive cancer models. Moreover, also able to reduce cell proliferation ALT cells, although the influence G4 stabilization on has so far been poorly investigated. Here we show that sensitivity comparable ALT-positive...
Abstract Telomeres are nucleoprotein structures at eukaryotic chromosome termini. Their stability is preserved by a six-protein complex named shelterin. Among these, TRF1 binds telomere duplex and assists DNA replication with mechanisms only partly clarified. Here we found that poly (ADP-ribose) polymerase 1 (PARP1) interacts covalently PARylates in S-phase modifying its affinity. Therefore, genetic pharmacological inhibition of PARP1 impairs the dynamic association bromodeoxyuridine...
Purpose The aim of this study was to describe the outcomes and complications retrograde intrarenal surgery (RIRS) for renal stones in a multi-institutional working group. Materials Methods From 2012 2014, we conducted prospective including all RIRS performed kidney 4 European centers. Demographic information, disease characteristics, perioperative postoperative data were gathered. Patients stone data, procedure results safety analyzed compared by descriptive statistics. Complications...
Abstract Proteins involved in DNA double-strand break (DSB) repair localize within the promyelocytic leukemia nuclear bodies (PML-NBs), whose disruption is at root of acute (APL) pathogenesis. All- trans -retinoic acid (RA) treatment induces PML-RAR α degradation, restores PML-NB functions, and causes terminal cell differentiation APL blasts. However, precise role APL-associated oncoprotein integrity DSB response leukemogenesis tumor suppression still lacking. Primary blasts isolated from...
The homeostatic control of lipid metabolism is essential for many fundamental physiological processes. A deep understanding its regulatory mechanisms pivotal to unravel prospective physiopathological factors and identify novel molecular targets that could be employed design promising therapies in the management disorders. Here, we investigated role bromodomain extraterminal domain (BET) proteins regulation metabolism. To reach this aim, used a loss-of-function approach by treating HepG2...
Abstract Background Aim of this study was to evaluate and compare perioperative outcomes transperitoneal (TP) retroperitoneal (TR) approaches in a multi-institutional cohort minimally invasive partial nephrectomy (MI-PN). Material methods All consecutive patients undergone MI-PN for clinical T1 renal tumors at 26 Italian centers (RECORd2 project) between 01/2013 12/2016 were evaluated, collecting the pre-, intra-, postoperative data. The then stratified according surgical approach, TP or RP....