A5001174706- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Organic Light-Emitting Diodes Research
- Photosynthetic Processes and Mechanisms
- Magnetism in coordination complexes
- Photochemistry and Electron Transfer Studies
- Lanthanide and Transition Metal Complexes
- Supramolecular Chemistry and Complexes
- Molecular Junctions and Nanostructures
- Poisoning and overdose treatments
- Molecular Sensors and Ion Detection
- Forensic Toxicology and Drug Analysis
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Synthesis and Properties of Aromatic Compounds
- Crystallography and molecular interactions
- Quantum and electron transport phenomena
- Pancreatic and Hepatic Oncology Research
- Forensic and Genetic Research
- Metal complexes synthesis and properties
- HER2/EGFR in Cancer Research
Azienda Ospedaliera di Cosenza
2024
Vita-Salute San Raffaele University
2010-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
University of Ferrara
2010-2020
San Raffaele University of Rome
2008-2017
Marconi University
2016
Roma Tre University
2016
National Interuniversity Consortium of Materials Science and Technology
2009-2014
University of Calabria
2009-2014
Objective The prognosis of either pituitary carcinoma or aggressive adenoma resistant to standard therapies is poor. We assessed the efficacy treatment with temozolomide, an oral second-generation alkylating agent, in a consecutive series six patients adenomas. Design This was 1-year prospective study temozolomide therapy (one case) atypical (five cases) therapies. There were three males and females. Age at enrollment ranged between 52 64 years. Temozolomide given orally dose 150–200 mg/m 2...
Mitochondrial therapy offers an alternative strategy for attenuation of hyperinflammation in cystic fibrosis lung disease.
A bis(Zn(II)-porphyrin) tweezer host with anthracene components as apex and side-arms has been synthesized. Mono- (pyridine) bidentate (4,4'-bipyridine) guests were used models for single double axial coordination inside the cavity, respectively. series of dipyridylporphyrin different substitution patterns excited-state energy levels have association constants tweezers that are order 10(6) M(-1), which is indicative complexation cavity. This can only occur upon an important distortion cavity...
Abstract Light‐induced generation of charges into an electron acceptor–donor phase‐segregated blend is studied. The made highly ordered nanoscopic crystals 3″‐methyl‐4″‐hexyl‐2,2′:5′,2″:5″,2‴:5‴,2″″‐quinquethiophene‐1″,1″‐dioxide embedded a regioregular poly(3‐hexylthiophene) matrix, acting as acceptor and donor materials, respectively. Kelvin probe force microscopy investigations reveal tendency for the nanocrystals to capture generated electrons whereas matrix becomes more positively...
Abstract New cationic Ir III materials of general formula [Ir(ppy) 2 (C n ‐bpy)]PF 6 {H(ppy) = 2‐phenylpyridine; C ‐bpy 3,4,5‐R‐4,4′‐benzoyloxymethyl‐2,2′‐bipyridine; 8, R OC 8 H 17 ; 0, H} were synthesised and fully characterised. Both complexes show high phosphorescence quantum yields in their condensed phases. Moreover, the introduction long alkoxy chains on bipyridne ligand ( 1 ) has induced mesomorphism, consequently a dynamic functional material with properties modulated by external...
Alterations in mucin (MUC) glycosylation and expression have been described cancer. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) can provide material for molecular biology analysis. This study assessed the feasibility of evaluating MUC from obtained by EUS-FNA studied profile benign malignant pancreatic lesions.A total 90 patients with solid or cystic lesions underwent FNA. The aspirated was used cytological analysis RNA extraction to assess pattern MUCs reverse...
Recent cardiology research studies have reported the role, function, and structure of mitochondrial permeability transition pore (mPTP) shown that its opening plays a key role in progression myocardial cell death secondary to reperfusion. In this manuscript, we validated new pharmacological approach as an adjunct reperfusion infarction (MI) treatment describe discovery, optimization, structure–activity relationship (SAR) first small-molecule mPTP inhibitors based on...
Abstract Proteins involved in DNA double-strand break (DSB) repair localize within the promyelocytic leukemia nuclear bodies (PML-NBs), whose disruption is at root of acute (APL) pathogenesis. All- trans -retinoic acid (RA) treatment induces PML-RAR α degradation, restores PML-NB functions, and causes terminal cell differentiation APL blasts. However, precise role APL-associated oncoprotein integrity DSB response leukemogenesis tumor suppression still lacking. Primary blasts isolated from...
The ability to identify the broadest range of targetable gene fusions is crucial facilitate personalized therapy selection for advanced lung adenocarcinoma (LuADs) patients harboring receptor tyrosine kinase (RTK) genomic alterations. In order evaluate most effective testing approach LuAD fusion detection, we analyzed 210 NSCLC selected clinical samples, comparing in situ (Fluorescence Situ Hybridization, FISH, and ImmunoHistoChemistry, IHC) molecular (targeted RNA Next-Generation...
The synthesis, crystal structure and luminescence properties of three cyclometalated Ir(III) complexes general formula [(ppy)2Ir(pam)]X, where X = Cl− (1), PF6− (2), ClO4−(3), pam 2-picolylamine, are described. While 2 3 crystallize in a unique form, two pseudo-polymorphs, solvated (1a) non-solvated (1b) species, have been observed for compound 1. 1a crystallizes the monoclinic centrosymmetric space group P2(1)/c. On contrary, 1b, non-centrosymmetric P2(1)2(1)2(1) Pca2(1) (2 3),...
Abstract [2]Catenanes made up of several polyether‐strapped porphyrin macrocycles interlinked with the cyclic electron acceptor cyclo bis (paraquat ‐p‐ phenylene) were spectroscopically, photophysically, and electrochemically characterized. The catenanes exhibit very rich redox behavior due to presence different interacting electro‐active subunits. patterns represent useful “fingerprints” that provide detailed information on electronic interactions chemical environments electroactive...
Photoinduced processes have been determined in a [2]catenane containing zinc(II) porphyrin, gold(III) and two free phenanthroline binding sites, Zn-Au(+), the corresponding copper(I) complex, Zn-Cu(+)-Au(+). In acetonitrile solution Zn-Au(+) is present different conformations: an extended one, L, which accounts for 40 % of total, compact S. L conformation, electron transfer from excited state Zn porphyrin to gold-porphyrin unit (k = 1.3x10(9) s(-1)) followed by slow recombination 8.3x10(7)...
Abstract “Alligator clips” suitable for grafting on H‐terminated silicon or gold surfaces have been incorporated into single‐molecule magnets (SMMs) of the Fe 4 family. Tripodal ligands 2,2‐bis(hydroxymethyl)‐10‐undecen‐1‐ol (H 3 L 1 ) and 11‐(acetylthio)‐2,2‐bis(hydroxymethyl)undecan‐1‐ol 2 used to replace six methoxide bridges in [Fe (OMe) 6 (dpm) ], affording new derivatives (L ] ( high yield (Hdpm = dipivaloylmethane). The molecular structures unambiguously established by XRD combined...
The solvent induced polymorphism observed in a cyclometalated iridium(III) ethylenediamine ionic complex is new tool to modulate and enhance emission the solid crystalline state.
Synthesis, crystal structural determination and photophysical properties of a series heteroleptic cationic cyclometalated iridium(III) derivatives general formula [(ppy)2Ir(en)]X (X = ClO4− (1), PF6− (2), Cl− (3), BPh4− (4)), are described. The assembly the common molecular building block allows to get highly luminescent crystalline materials or assemble poorly supramolecular channelled architectures, for which additional contribution oxygen quenching effects has been observed. Moreover,...
This study was carried out to evaluate data about trauma-related winter sports, including risk factors such as high speed, gender, age, alcohol consumption, details the accident and snow conditions.A retrospective review conducted determine injury patterns crash circumstances in holiday skiers snowboarders. The recorded were obtained from database of Pre-Hospital Emergency Registry six skiing areas Dolomite mountains during seasons November 2004-May 2009, for major traumas Ski Patrol Injury...
The neutral luminescent tris-cyclometallated 2-phenylpyridine iridium(III) complex, (fac-Ir(ppy)3, [Ir]) following a self-assembling procedure, has been successfully located in the cavities of mesostructured silica materials through surfactant-mediated process. Two different structure-directing agents, cationic cetyltrimethyl ammonium bromide (CTAB) and non-ionic poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (P123) were tested. structural features induced by...
The first example of spontaneous self‐assembly ionic octahedral Ir(III) complexes containing carboxylates counterions into luminescent ordered aqueous gel phases is reported. formed at 2.5% w/w (“ Ir‐C i ”:H 2 0) are investigated by POM, 1 H and NMR UV–vis spectroscopies, whereas a detailed structural analysis WAXS, SAXS, SANS experiments performed for the acetate complex, in both anisotropic isotropic phases. This comprehensive investigation shows that complex with shortest carboxylate...
The induction of columnar mesomorphism in ionic heteroleptic octahedral tris-2,2′-bipyridine Ru(II) complexes, through a modulation the ligand structure, produces large effect on phosphorescence quantum efficiency (Φ = 0.14) demonstrating that synthesis liquid crystalline compound containing hexacoordinated chromophore is helpful strategy design room temperature multifunctional soft materials, very appealing for light-emitting electrochemical cells or solid-state photovoltaic applications.
Two anionic iridium complexes [(R-ppy)2Ir(O^N)]TBA with R-ppy = 2-phenylpyridine or 4,5'-dimethyl-2-phenylpyridine, O^N dianionic form of orotic acid and TBA tetrabutylammonium have been synthesised fully characterised by UV-Vis, emission, IR, NMR cyclic voltammetric studies. These cyclometallated luminescent containing a bidentate ancillary ligand show bright emission (60-70% PLQY) maxima in the green region visible spectrum. Coupled ionic [(ppy)2Ir(N^N)]X, where N^N 2-picolylamine...