A5048378222- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Cancer Immunotherapy and Biomarkers
- Psychedelics and Drug Studies
- Neuroscience and Neuropharmacology Research
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Bladder and Urothelial Cancer Treatments
- Medical Device Sterilization and Disinfection
- Renal and related cancers
- Pharmacovigilance and Adverse Drug Reactions
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Research Studies
- Alcohol Consumption and Health Effects
- Safe Handling of Antineoplastic Drugs
- Pharmacological Effects of Natural Compounds
- Antiplatelet Therapy and Cardiovascular Diseases
- Intestinal and Peritoneal Adhesions
- Influenza Virus Research Studies
- Intramuscular injections and effects
- Analytical Methods in Pharmaceuticals
- Bacillus and Francisella bacterial research
University of Padua
2021-2025
Italian Society of Physiotherapy
2024
Azienda Ospedaliera di Padova
2022-2023
Pharmac
2022
Università Cattolica del Sacro Cuore
2017-2019
University of Ferrara
2015-2018
On 21 December 2020 the European Commission granted conditional marketing authorisation in Union for anti-COVID-19 mRNA vaccine Bnt162b2 (Comirnaty, Pfizer/BioNTech). The main endpoint of this epidemiological, observational, prospective and monocentric study was to identify number, types, severity adverse events following immunisation that occurred subjects who had been previously infected with COVID-19, those not, after vaccination Comirnaty, compare two groups looking at within a month...
Introduction 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 are 3 novel third‐generation fluorinate synthetic cannabinoids that illegally marketed as incense, herbal preparations, or research chemicals for their psychoactive cannabis‐like effects. Methods The present study aims at investigating the in vitro vivo pharmacological activity of male CD‐1 mice, comparing effects with those caused by administration Δ 9 ‐THC JWH‐018. In competition binding experiments revealed a nanomolar affinity potency on...
JWH-018 and AKB48 are two synthetic cannabinoids (SCBs) belonging to different structural classes illegally marketed as incense, herbal preparations, or chemical supply for theirs psychoactive cannabis-like effects. Clinical reports from emergency room reported psychomotor agitation one of the most frequent effects in people assuming SCBs. This study aimed investigate psychostimulant properties male CD-1 mice compare their behavioral biochemical with those caused by cocaine amphetamine. In...
The proven efficacy of mTOR inhibitors (mTORIs), tyrosine kinase (TKIs) or immune checkpoint (ICIs) in metastatic renal cell carcinoma (RCC) suggests that these agents should be investigated as adjuvant therapy with the aim eliminating undetectable microscopic residual disease after curative resection. our study was to compare treatments using an innovative method reconstructing individual patient data. Nine phase III trials describing RCC were selected. IPDfromKM used reconstruct data from...
Recently, numerous combination therapies based on immune checkpoint inhibitors (ICI) and vascular endothelial growth factor (VEGF) have been proposed as first-line treatments for advanced renal cell carcinoma (aRCC). Our study aimed to compare the efficacy of these regimens by application an innovative method that reconstructs individual patient data.Six phase III studies describing different aRCC were selected. Individual data reconstructed from Kaplan-Meier (KM) curves through "Shiny...
Background: Patients with locally advanced/metastatic urothelial cancer have been conventionally treated platinum-based chemotherapy. Recently, numerous new treatments proposed to improve overall survival (OS) and reduce adverse effects, but no head-to-head direct comparison is available. Methods: We considered: a) monotherapy immune checkpoint inhibitors (ICI); b) combinations of an ICI chemotherapy; c) other drugs. An indirect was performed identify the regimens most effective in...
Among novel psychoactive substances notified to EMCDDA and Europol were 1-cyclohexyl-x-methoxybenzene stereoisomers (ortho, meta, para). These share some structural characteristics with phencyclidine tramadol. Nowadays, no information on the pharmacological toxicological effects evoked by are reported. The aim of this study was investigate effect each one stereoisomer visual stimulation, body temperature, acute thermal pain, motor activity in mice.Mice evaluated behavioral tests carried out...
Objective This paper presents a preliminary experience based on the "one-to-many" approach of Shiny method. Numerous (or "many") treatments for advanced or metastatic urothelial carcinoma have recently been reviewed. More recently, "one" potentially innovative treatment has made available. Our analysis was aimed at assessing benefits new in comparison with alternatives developed previously. Materials and methods The method employed to reconstruct patient-level survival data. information...