A5069992666- Health Systems, Economic Evaluations, Quality of Life
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Statistical Methods in Clinical Trials
- Pharmaceutical Practices and Patient Outcomes
- Biosimilars and Bioanalytical Methods
- Acute Ischemic Stroke Management
- Acute Lymphoblastic Leukemia research
- Stroke Rehabilitation and Recovery
- Cancer Genomics and Diagnostics
- Safe Handling of Antineoplastic Drugs
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Pharmaceutical studies and practices
- Multiple Myeloma Research and Treatments
- Economic and Financial Impacts of Cancer
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Protein Degradation and Inhibitors
- Gastric Cancer Management and Outcomes
- Chronic Myeloid Leukemia Treatments
- Antifungal resistance and susceptibility
- Gynecological conditions and treatments
- COVID-19 and Mental Health
Italian Society of Physiotherapy
2017-2023
Ospedale Santa Chiara
2022
Ito Hospital
2022
AULSS 2 Marca Trevigiana
2022
University of Padua
2022
Agenzia Regionale di Sanità della Toscana
2021-2022
Regione Toscana
2020-2022
Cambridge University Press
2016
New York University Press
2016
Finnish Institute for Health and Welfare
2016
Introduction The phase III Keynote-189 trial established a first-line treatment combining pembrolizumab with pemetrexed and platinum as standard for patients stage IV non-small cell lung cancer (NSCLC) without known EGFR ALK driver mutations independent of programmed death ligand 1 (PD-L1) expression. However, in Italy, eligibility the National Health Service payment program is limited to PD-L1 <50%. PEMBROREAL study assesses real-world effectiveness safety eligible program. Methods...
Results from the phase III Keynote-024 clinical trial established pembrolizumab monotherapy as first-line standard of care for patients with metastatic NSCLC who have PD-L1 expression ≥ 50%, EGFR, and ALK wild-type tumors. However, given differences between treated in routine practice those a trial, real-world data are needed to confirm treatment benefit practice. Given lack on large cohorts long follow-ups, we designed an observational retrospective study were pembrolizumab, starting its...
OPINION article Front. Pharmacol., 24 January 2017Sec. Drugs Outcomes Research and Policies Volume 8 - 2017 | https://doi.org/10.3389/fphar.2017.00014
Results from the phase III Keynote-024 clinical trial have established Pembrolizumab monotherapy as first-line standard of care for patients with metastatic NSCLC who PD-L1 expression ≥ 50%, EGFR and ALK wild-type. However, given differences between treated in routine practice within a trial, real-world data are needed to confirm treatment benefit practice. Given lack on large cohorts long follow-up, we designed retrospective observational study were Pembrolizumab, starting its reimbursement...
Recently, numerous combination therapies based on immune checkpoint inhibitors (ICI) and vascular endothelial growth factor (VEGF) have been proposed as first-line treatments for advanced renal cell carcinoma (aRCC). Our study aimed to compare the efficacy of these regimens by application an innovative method that reconstructs individual patient data.Six phase III studies describing different aRCC were selected. Individual data reconstructed from Kaplan-Meier (KM) curves through "Shiny...
Purpose: A high number of adverse drug reactions (ADRs), mainly caused by drug–drug interactions (DDIs), occur in neurological wards and few data are available about incidence prevalence DDIs this context. This study investigated—(1) the drug–disease patients admitted to a unit Italy, (2) risk factors for DDIs, (3) diseases classes mostly involved interactions. Methods: For 2 months, we performed retrospective, observational St Bassiano Hospital, enrolling 79 who received prescription at...
Health technology assessment (HTA) yields information that can be ideally used to address deficiencies in health systems and create a wider understanding of the impact different policy considerations around reimbursement use. The structure HTA programs varies across jurisdictions according decision-maker needs. Moreover, conducting requires specialized skills. Effective decision making should include multiple criteria (medical, economic, technical, ethical, social, legal, cultural)...
In patients with metastatic melanoma, ipilimumab has been shown to improve long-term survival. This observational multicenter study reports clinical outcomes of 418 treated second-line from February 2013 August 2014. Median overall survival (OS) was 6.43 months (95%CI: 5.45–7.42; n = 300), while median progression-free (PFS) 3.7 3.23–4.17; 188). Demographic factors, such as sex or number previous therapies did not affect OS. Survival shorter in ECOG > 0 (Eastern Cooperative Oncology Group,...
Epidemiological studies on uterine fibroids (UFs) are mostly based surveys or analyses of small samples patients. In 50% women, the quality life is worsened by disease-related symptoms; furthermore, treatments imply a remarkable health care cost. The aim this observational study was to analyze large sample Italian patients with UFs and assess epidemiology, appropriateness treatments, consumption resources.Data were collected through data-linkage technique from five administrative databases....
Abstract Background Depending on the health system context and demands of relevant stakeholders in countries, need, organizational structure, prerequisites for enabling capacity building development technology assessment (HTA) will vary. Core competencies are instrumental this include essential knowledge, skills, attitudes (KSAs). They provide blocks delivering high-quality effective practices HTA. We aimed to systematically explore develop an overview core necessary Methods This study was...
Background The consequences of stroke must be assessed not only in terms incidence and mortality rates, but also disability, which may persist long after the acute phase. Thrombolysis, if timely administered, can effectively reduce post-stroke disability. Aims economic model presented herein aims to evaluate, eligible patients, effects alteplase on disability related costs over three-years. Methods analysis was developed basis four key components: clinical outcomes from international trials,...
Objective: To collect pilot data on medication disposal practices of unused and expired medications from three cities in countries. Methods: A cross-sectional survey was conducted Pittsburgh, United States (US); Turin, Italy; Kobe, Japan. convenience sampling utilized through drug take-back programs US; pharmacy customers students family members Descriptive analysis to assess including attitudes beliefs respondents. Results: The sample included 342 respondents [99 (Pittsburgh, US); 168...