A5062142605- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Physics and Applications
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Metal complexes synthesis and properties
- Prostate Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Organometallic Complex Synthesis and Catalysis
- Advanced Radiotherapy Techniques
- Crystallography and molecular interactions
- Chemical Synthesis and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Orthopaedic implants and arthroplasty
- Particle accelerators and beam dynamics
University of Ferrara
2016-2025
Ospedale San Bortolo
2022
Terra
2022
Weatherford College
2022
Arcispedale Sant'Anna
2018
Istituto Nazionale di Fisica Nucleare, Sezione di Ferrara
2011-2014
Woman's Hospital
2003
University of Padua
1999
University of Bologna
1997
Université Grenoble Alpes
1997
Even today, techentium-99m represents the radionuclide of choice for diagnostic radio-imaging applications. Its peculiar physical and chemical properties make it particularly suitable medical imaging. By use molecular probes perfusion radiotracers, provides rapid non-invasive evaluation function, physiology, and/or pathology organs. The versatile chemistry technetium-99m, due to its multi-oxidation states, and, consequently, ability produce a variety complexes with particular desired...
99mTc is the most commonly used radionuclide in field of diagnostic imaging, a noninvasive method intended to diagnose disease, assess disease state and monitor effects treatments. Annually, use 99mTc, covers about 85% nuclear medicine applications. This isotope releases gamma rays at same wavelength as conventional X-ray equipment, owing its short half-life (t½ = 6 h) ideal for imaging. A patient can be injected with small amount within 24 h almost 94% would have decayed left body, limiting...
Radio-ligand therapy (RLT) with177Lu-PSMA-617 is a promising option for patients with metastatic castration-resistant prostate-cancer (mCRPC). A prospective phase-II study (EUDRACT/RSO,2016-002732-32) on mCRPC ongoing at IRST (Meldola, Italy). total of 9 (median age: 68 y, range: 53⁻85) were enrolled dosimetry evaluation parotid glands (PGs), kidneys, red marrow (RM) and whole body (WB). Folic polyglutamate tablets orally administered as PGs protectors 500 mL 10% mannitol solution was...
Abstract Background In recent years, fibroblast activating protein (FAP), a biomarker overexpressed by cancer-associated fibroblasts, has emerged as one of the most promising biomarkers in oncology. Similarly, FAP overexpression been detected various fibroblast-mediated inflammatory conditions such liver cirrhosis and idiopathic pulmonary fibrosis. Along this trajectory, FAP-targeted positron emission tomography (PET), utilizing inhibitors (FAPi) labeled with emitters, gained traction...
Monosubstituted [M(N)Cl(2)(POP)] [M = Tc, 1; Re, 2] and [M(N)Cl(2)(PNP)] 3; 4] complexes were prepared by reaction of the precursors [M(N)Cl(4)](-) [M(N)Cl(2)(PPh(3))(2)] (M Re) with diphosphine ligands bis(2-diphenylphosphinoethyl)ether (POP) bis(2-diphenylphosphinoethyl)methoxyethylamine (PNP) in refluxing dichloromethane/methanol solutions. In these compounds, acted as a chelating ligand bound to metal center through two phosphorus atoms. Considering also weak interaction heteroatom (N or...
At the Department of Physics University Pisa, Italy, a new and fully engineered version YAP-(S)PET small animal scanner has been recently installed. The is able to perform both PET SPECT studies on animals. made up four heads: each one composed 4/spl times/4 cm/sup 2/ YAlO/sub 3/:Ce (or YAP:Ce) matrix 20/spl times/20 elements, 2/spl times/2/spl times/25 mm/sup 3/ each, coupled Position Sensitive Photomultiplier (PS-PMT) (Hamamatsu R2486). modules are positioned rotating gantry. switching...
JWH-018 and AKB48 are two synthetic cannabinoids (SCBs) belonging to different structural classes illegally marketed as incense, herbal preparations, or chemical supply for theirs psychoactive cannabis-like effects. Clinical reports from emergency room reported psychomotor agitation one of the most frequent effects in people assuming SCBs. This study aimed investigate psychostimulant properties male CD-1 mice compare their behavioral biochemical with those caused by cocaine amphetamine. In...
The 188 Re radioisotope represents a useful for the preparation of radiopharmaceuticals therapeutic applications, particularly because its favorable nuclear properties. nuclide decay pattern is through emission principle beta particle having 2.12 MeV maximum energy, which enough to penetrate and destroy abnormal tissues, gamma rays (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
the gamma-emitting radionuclide Technetium-99m (99mTc) is still workhorse of Single Photon Emission Computed Tomography (SPECT) as it used worldwide for diagnosis a variety phatological conditions. 99mTc obtained from 99Mo/99mTc generators pertechnetate ion, which ubiquitous starting material preparation radiopharmaceuticals. 99Mo in such currently produced nuclear fission reactors by-product 235U fission. Here we investigated an alternative route production by irradiating natural metallic...
Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) is a strong prognostic factor in breast cancer (BC). The aim of this study was to investigate whether semiquantitative parameters derived from baseline [18F]Fluorodeoxyglucose ([18F]FDG) positron emission computed tomography/computed tomography (PET/CT) could predict pCR NAC and survival outcomes patients affected by different molecular subtypes BC. We retrospectively retrieved the databases two Italian hospitals...
Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that extensively used for the high-resolution of soft tissues. To obtain high-definition pictures tissues or whole organism this enhanced by use contrast agents. Gadolinium-based agents have an excellent safety profile. However, over last two decades, some specific concerns surfaced. Mn(II) has different favorable physicochemical characteristics and good toxicity profile, which makes it alternative to...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTGeometrically Controlled Selective Formation of Nitrido Technetium(V) Asymmetrical Heterocomplexes with Bidentate LigandsCristina Bolzati, Alessandra Boschi, Adriano Duatti, Sushumna Prakash, Licia Uccelli, Fiorenzo Refosco, Francesco Tisato, and Giuliano BandoliView Author Information Laboratory Nuclear Medicine Department Clinical & Experimental University Ferrara, Via L. Borsari, 46, 44100 Italy ICTIMA, CNR, Corso Stati Uniti, 4, 35020...
A lyophilized kit formulation for the efficient labelling of lipiodol with generator-produced rhenium-188 is described. The preliminary preparation lipophilic complex bis-(diethyldithiocarbamato)nitrido (188ReN-DEDC) was carried out using a two-vial containing S-methyl-N-methyl-dithiocarbazate, SnCl2 and sodium oxalate in first vial, diethyldithiocarbamate carbonate buffer second vial. After mixing reaction solution lipiodol, 188ReN-DEDC quantitatively extracted retained by this hydrophobic...