A5068336986- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Particle accelerators and beam dynamics
- Nuclear Materials and Properties
- Fusion materials and technologies
- Metal and Thin Film Mechanics
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Boron Compounds in Chemistry
- Superconducting Materials and Applications
- Semiconductor materials and devices
- Radioactivity and Radon Measurements
- Zeolite Catalysis and Synthesis
- Nuclear reactor physics and engineering
- Mass Spectrometry Techniques and Applications
- Medical Imaging and Pathology Studies
- Atomic and Subatomic Physics Research
- Ga2O3 and related materials
- Metallic Glasses and Amorphous Alloys
- Chemical Synthesis and Characterization
- Muon and positron interactions and applications
- Microwave Dielectric Ceramics Synthesis
- Particle Accelerators and Free-Electron Lasers
- Radioactive element chemistry and processing
- Chemical Reactions and Isotopes
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro
2013-2024
Belgian Nuclear Research Centre
2022-2023
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2023
Istituto Nazionale di Fisica Nucleare
2018-2021
University of Ferrara
2015-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Ferrara
2020
STMicroelectronics (Canada)
2019
University of Padua
2013
Technetium-99m (99mTc) is the most used radionuclide worldwide in nuclear medicine for diagnostic imaging procedures. 99mTc typically extracted from portable generators containing 99Mo, which produced normally reactors as a fission product of highly enriched Uranium material. Due to unexpected outages or planned and unplanned reactor shutdown, significant shortages appeared problem since 2008 The alternative cyclotron-based approach through 100Mo(p,2n)99mTc reaction considered one promising...
Abstract Since more than 100 years, the adsorption of radioactive noble gas radon ( 222 Rn) is performed on activated charcoal at cryogenic temperatures. There little—if any—progress in field ambient conditions to facilitate development simple and compact systems. We report here truly remarkable property synthetic silver-exchanged zeolites Ag-ETS-10 Ag-ZSM-5 strongly adsorb room temperature. Rn breakthrough experiments nitrogen carrier have shown that these materials exhibit coefficients...
[Formula: see text]Ac is a radio-isotope that can be linked to biological vector molecules treat certain distributed cancers using targeted alpha therapy. However, developing text]Ac-labelled radiopharmaceuticals remains challenge due the supply shortage of pure itself. Several techniques obtain are being investigated, amongst which high-energy proton spallation thorium or uranium combined with resonant laser ionization and mass separation. As proof-of-principle, we perform off-line...
A novel method for the production of high-performing, flexible 3D-printed siloxane-based scintillators is here described. It consists in synthesis via sol-gel phenyl-bearing siloxane resins with methacrylate functionalities suitable photopolymerization by UV illumination, therefore shaped at desired geometries through additive manufacturing, namely digital light processing (DLP). Both hydrolytic and non-hydrolytic approaches are adopted to promote reactivity diphenyl bearing alkoxysilane...
Zirconium-89 (89Zr) is an emerging radionuclide for positron emission tomography (PET), with nuclear properties suitable imaging slow biological processes in cellular targets. The 89Y(p,n)89Zr reaction commonly exploited as the main production route medical cyclotrons accelerating low-energy (< 20 MeV) and low-current 100 μA) proton beams. Usually, natural yttrium solid targets manufactured by different methods, including electrodeposition, sputtering, compressed powders, foils, were...
The High Energy Vibrational Powder Plating (HIVIPP) technique allows for the preparation of targets starting from refractory metal powders with negligible material losses during process, thus preserving expensive isotope-enriched materials. An upgraded HIVIPP apparatus was developed at Legnaro National Laboratory Institute Nuclear Physics (INFN-LNL), and it is reported in this work. Particular attention paid to design sample holder, automation power supply, control all aim obtaining a...
Protective corrosion resistant coatings serve for decreasing the amount of ionic contaminants from Havar® entrance foils targets [18F] production. The damage coated is caused mainly by diffusion highly reactive products water radiolysis through protective film toward substrate. Since amorphous metal alloys (metallic glasses) are well-known to perform a high resistance, glass forming ability, microstructure and barrier efficiency binary containing chemically inert Nb, Ta, Zr were...
Magnetron sputtering is proposed here as an innovative method for the deposition of a material layer onto appropriate backing plate cyclotron solid targets aimed at medical radioisotopes production. In this study, to deposit thick, high-density, high-thickness-uniformity, and stress-free films high adherence was developed by optimizing fundamental parameters: gas pressure, substrate temperature, using multilayer mode, well. This realize Mo-100 Y-nat biomedical production Tc-99m Zr-89...
Thin targets of isotopically enriched 48Ti metallic powder on Al foil substrates for the nuclear cross-section measurements were manufactured using HIgh energy VIbrational Powders Plating method in vacuum. The target areal thickness 0.2–2 mg/cm2 was achieved as measured by weighing well Elastic Backscattering Spectroscopy (EBS) analysis. quality targets, particular deposit uniformity, evaluated Scanning Electron Microscope (SEM) assisted Energy Dispersive (EDS). microstructure HIVIPP...
The cross-sections of the 48Ti(p,x)47Sc, 46cSc, 44mSc, 44gSc, 43Sc, and 48V nuclear reactions were measured from 18 to 70 MeV, with particular attention 47Sc production. Enriched 48Ti powder was deposited on an aluminum backing obtained targets characterized via elastic backscattering spectroscopy at INFN-LNL. Targets exposed low-intensity proton irradiation using stacked-foils technique ARRONAX facility. Activated samples γ-spectrometry; results compared data int he literature theoretical...
Abstract LARAMED project aims to set up an advanced science and technology facility develop new efficient methods produce medical radioisotopes at Legnaro National laboratories of Institute Nuclear Physics. Waiting for the full operation, group has already started working on cyclotron production several conventional emerging radionuclides. Suitable target preparation is one most critical aspects in radioisotopes. investigated a non-classical techniques metallic preparation. Magnetron...
67Cu, 186Re and 47Sc are theranostic radionuclides in the spot-light of scientific community: insufficient availability is limiting their use clinical pre-clinical studies. The aim this work analysis production by using high-energy high-intensity cyclotrons, as one installed at INFN-LNL framework SPES project, exploring promising nuclear reactions induced proton-beams.
The LARAMED project, acronym for LAboratory of RAdioisotopes MEDicine, is the new research infrastructure being established at Legnaro National Laboratories (LNL), focused on production novel medical radionuclides, actually unavailable scientific community. This work presents recent advancements laboratories and bunkers in SPES facility, where 70-MeV high current proton cyclotron was installed 2015 to perform not only fundamental nuclear physics studies but also activities related...
Chemically inert coatings on Havar® entrance foils of the targets for [18F] production via proton irradiation enriched water at pressurized conditions are needed to decrease amount ionic contaminants released from Havar®. In order find most effective protective coatings, Nb-based coating microstructure and barrier properties have been correlated with deposition parameters such as substrate temperature, applied bias, rate sputtering gas pressure. Aluminated quartz used a allowed us verify...
A closed-loop technology aiming at recycling the highly 100Mo-enriched molybdenum target material has been developed in framework of international research efforts on alternative, cyclotron-based 99mTc radionuclide production. The main procedure steps include (i) 100Mo-based manufacturing; (ii) irradiation under proton beam; (iii) dissolution 100Mo layer containing 9×Tc radionuclides (produced by opened nuclear reaction routes) concentrated H2O2 solution; and (iv) Mo/Tc separation...
Chemically inert coatings on Havar® entrance foils of the targets for [18F] production via proton irradiation enriched water at pressurized conditions are needed to decrease amount ionic contaminants released from Havar®. During current investigation, magnetron sputtered niobium and oxide were chosen as candidates protective because their superior chemical resistance. Aluminated quartz substrates allowed us verify protection efficiency desirable diffusion barriers. Two modeling corrosion...
The number of medical procedures involving the use cyclotron-produced radionuclides is constantly growing year by year. design and construction cyclotron targets appropriate for production interest are most challenging issues. radionuclide suffer from two main corrosion problems: due to proton-irradiated water liquid metal embrittlement. target limits ability select an ideal material that meets all following requirements: machinability or ease construction, high melting temperature, thermal...
Abstract 225 Ac is a radio-isotope that can be linked to biological vector molecules treat certain distributed cancers using targeted alpha therapy. However, developing Ac-labelled radiopharmaceuticals remains challenge due the supply shortage of pure itself. Several techniques obtain are being investigated, amongst which high-energy proton spallation thorium or uranium combined with resonant laser ionization and mass separation. As proof-of-principle, we perform separation on two samples...