A5056814396- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Nuclear reactor physics and engineering
- Particle accelerators and beam dynamics
- Radioactive Decay and Measurement Techniques
- Medical Imaging and Pathology Studies
- Graphite, nuclear technology, radiation studies
- Chemical Reactions and Isotopes
- Nuclear Materials and Properties
- Radiation Detection and Scintillator Technologies
- Rare-earth and actinide compounds
- Advanced Condensed Matter Physics
- Neuroendocrine Tumor Research Advances
- Radioactivity and Radon Measurements
- Fusion materials and technologies
- Mass Spectrometry Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Lung Cancer Research Studies
- Physics of Superconductivity and Magnetism
- Machine Learning in Healthcare
- Distributed and Parallel Computing Systems
- Advanced Radiotherapy Techniques
Laboratoire de Physique Subatomique et des Technologies Associées
2013-2024
IMT Atlantique
2016-2024
European Organization for Nuclear Research
2018-2024
KU Leuven
2020-2023
University of Latvia
2022-2023
Riga Stradiņš University
2023
Riga Technical University
2023
Nantes Université
2014-2022
Centre National de la Recherche Scientifique
2014-2022
Institut National de Physique Nucléaire et de Physique des Particules
2022
Terbium features four clinically interesting radionuclides for application in nuclear medicine: terbium-149, terbium-152, terbium-155, and terbium-161.Their identical chemical properties enable the synthesis of radiopharmaceuticals with same pharmacokinetic character, while their distinctive decay characteristics make them valuable both imaging therapeutic applications.In particular, terbium-152 terbium-155 are useful candidates positron emission tomography (PET) single photon computed...
Among the large number of radionuclides medical interest, Sc-44 is promising for PET imaging. Either ground-state Sc-44g or metastable-state Sc-44m can be used such applications, depending on molecule as vector. This study compares production rates both states, when protons deuterons are projectiles an enriched Calcium-44 target. work presents first set data deuteron route. The results compared with TALYS code. Thick-Target Yields and calculated those proton route three different scenarios:...
[Formula: see text]Ac is a radio-isotope that can be linked to biological vector molecules treat certain distributed cancers using targeted alpha therapy. However, developing text]Ac-labelled radiopharmaceuticals remains challenge due the supply shortage of pure itself. Several techniques obtain are being investigated, amongst which high-energy proton spallation thorium or uranium combined with resonant laser ionization and mass separation. As proof-of-principle, we perform off-line...
Mo-99 TTY obtain in this work is up to 25%
The radionuclides 43Sc, 44g/mSc, and 47Sc can be produced cost-effectively in sufficient yield for medical research applications by irradiating natTi natV target materials with protons. Maximizing the production of therapeutic highest cross section energy range 24–70 MeV results co-production long-lived, high-γ-ray-energy 46Sc 48Sc contaminants if one does not use enriched materials. Mass separation used to obtain high molar activity isotopically pure Sc from natural materials; however,...
Samarium-153 ( 153 Sm) is a highly interesting radionuclide within the field of targeted therapy because its favorable decay characteristics. Sm has half-life 1.93 d and decays into stable daughter nuclide Eu) whereupon β − particles [E = 705 keV (30%), 635 (50%)] are emitted which suitable for therapy. also emits γ photons [103 (28%)] allowing SPECT imaging, value in theranostics. However, full potential nuclear medicine currently not being exploited radionuclide's limited specific activity...
Thulium-167 is a promising radionuclide for nuclear medicine applications with potential use both diagnosis and therapy ("theragnostics") in disseminated tumor cells small metastases, due to suitable gamma-line as well conversion/Auger electron energies. However, adequate delivery methods are yet be developed accompanying radiobiological effects investigated, demanding the availability of 167Tm appropriate activities quality. We report herein on production radionuclidically pure from...
The β--particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched 168Er2O3. This path, however, not suitable for receptor-targeted therapy, where high specific molar activities are required. In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the activity by separating 169Er from 168Er targets. efficiency...
Terbium-155 has been identified for its potential single-photon emission computed tomography (SPECT) in nuclear medicine. For activity measurements, an accurate and precise half-life of this radionuclide is required. However, the currently evaluated 5.32(6) d with a relative standard uncertainty 1.1% determines precision possible. Limited literature measurements available all reported investigations are prior to 1970. Further therefore needed confirm accuracy improve use clinical setting....
The gamma spectroscopy technique is commonly used in many applications to evaluate the activity of emitters a given sample. This assessment particular interest for disposal radioactive waste or clearance purposes. However, these specific applications, one needs show that evaluated activities are reasonably conservative. paper shows an application methodology developed quantify efficiency calibration curve uncertainties originating from test case sample and its associated geometry modelling....
CERN-MEDICIS is an off-line isotope separator facility for the extraction of radioisotopes from irradiated targets interest to medical applications. The beamline, between ion source and collection chamber, consists focusing elements, a dipole magnet mass spectrometer recovered LISOL in Louvain-la-Neuve. latter has been modified compatibility with MEDICIS, including installation window injecting laser light into resonance photo-ionization. Ion beam optics magnetic field modeling using SIMION...
Samarium-153 is a promising theranostic radionuclide, but low molar activities (Am) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of 152Sm in the SCK CEN BR2 reactor with mass separation at CERN/MEDICIS yielded high-Am 153Sm. In this proof-of-concept study, we further evaluated potential 153Sm TRNT by radiolabeling to DOTA-TATE, well-established carrier molecule binding somatostatin...