Melchiore Giganti

ORCID: 0000-0002-5319-8685
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About
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Research Areas
  • Medical Imaging Techniques and Applications
  • Radiopharmaceutical Chemistry and Applications
  • Medical Imaging and Pathology Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Cardiac Imaging and Diagnostics
  • Advanced MRI Techniques and Applications
  • Cancer, Hypoxia, and Metabolism
  • Advanced X-ray and CT Imaging
  • Bone and Joint Diseases
  • MRI in cancer diagnosis
  • Lanthanide and Transition Metal Complexes
  • Cardiovascular Disease and Adiposity
  • Bone health and osteoporosis research
  • Renal cell carcinoma treatment
  • Adrenal and Paraganglionic Tumors
  • Liver Disease Diagnosis and Treatment
  • Advanced Radiotherapy Techniques
  • Cardiovascular Function and Risk Factors
  • Radiation Detection and Scintillator Technologies
  • Thyroid Cancer Diagnosis and Treatment
  • COVID-19 and healthcare impacts
  • Cardiac Valve Diseases and Treatments
  • Systemic Lupus Erythematosus Research
  • Monoclonal and Polyclonal Antibodies Research
  • Bone health and treatments

University of Ferrara
2016-2025

Arcispedale Sant'Anna
2004-2022

Istituti Ospitalieri di Cremona
2020

Azienda Socio Sanitaria Territoriale di Cremona
2020

Lithuanian University of Health Sciences
2016

Universidade do Porto
2016

Centro Hospitalar de Vila Nova de Gaia
2016

Ospedale SS. Annunziata
2016

Istituto Nazionale di Fisica Nucleare, Sezione di Ferrara
2013

St. Anna Hospital
1997

Abstract Purpose Build machine learning (ML) models able to predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients based on conventional and radiomic signatures extracted from baseline [ 18 F]FDG PET/CT. Material methods Primary tumor the most significant lymph node metastasis were manually segmented PET/CT of 52 newly diagnosed BC patients. Clinical parameters, NAC semiquantitative PET parameters collected. The standard reference...

10.1007/s11547-025-01958-4 article EN cc-by La radiologia medica 2025-01-28

Background: This study aims to investigate stability and reproducibility of radiomics biomarkers for adrenal lesion characterization across different software packages. Methods: Unenhanced CT images from patients with tumors were analyzed. Radiomic features extracted using SOPHIA Radiomics SIBEX software. The datasets underwent Z-score normalization. Statistical comparisons made two-sample t-tests Spearman correlation coefficients. Three classification models—Logistic Regression, Linear...

10.3390/life15040560 article EN cc-by Life 2025-03-31

Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that extensively used for the high-resolution of soft tissues. To obtain high-definition pictures tissues or whole organism this enhanced by use contrast agents. Gadolinium-based agents have an excellent safety profile. However, over last two decades, some specific concerns surfaced. Mn(II) has different favorable physicochemical characteristics and good toxicity profile, which makes it alternative to...

10.3390/ijms24043461 article EN International Journal of Molecular Sciences 2023-02-09

A lyophilized kit formulation for the efficient labelling of lipiodol with generator-produced rhenium-188 is described. The preliminary preparation lipophilic complex bis-(diethyldithiocarbamato)nitrido (188ReN-DEDC) was carried out using a two-vial containing S-methyl-N-methyl-dithiocarbazate, SnCl2 and sodium oxalate in first vial, diethyldithiocarbamate carbonate buffer second vial. After mixing reaction solution lipiodol, 188ReN-DEDC quantitatively extracted retained by this hydrophobic...

10.1097/01.mnm.0000130241.22068.45 article EN Nuclear Medicine Communications 2004-06-16

Academic journals have published a large number of papers in the therapeutic nuclear medicine (NM) research field last 10 years. Despite this, literature analysis has never before been made to point out interest radionuclides (RNs). For this reason, present study aims specifically analyze output on radiometals from 2008 2018, with intent quantify and identify global trends scientific emphasize interdisciplinary nature field. The data search targeted conventional (131I, 90Y, 177Lu, 188Re,...

10.3390/molecules24030640 article EN cc-by Molecules 2019-02-12

Abstract How to differentiate with MRI-based techniques testicular germ (TGCTs) and non-germ cell tumors (TNGCTs) is still under debate Radiomics may be the turning key. Our purpose investigate performance of signatures for preoperative prediction neoplasm histology. The aim twofold: (i), differentiating TGCTs TNGCTs status (ii) seminomas (SGCTs) from non-seminomatous (NSGCTs). Forty-two patients pathology-proven neoplasms referred pre-treatment MRI, were retrospectively enrolled. Thirty-two...

10.1038/s41598-021-83023-4 article EN cc-by Scientific Reports 2021-02-10

Abstract Objectives In this study, we developed a radiomic signature for the classification of benign lipid-poor adenomas, which may potentially help clinicians limit number unnecessary investigations in clinical practice. Indeterminate adrenal lesions and malignant nature exhibit different values key radiomics features. Methods Patients who had available histopathology reports non-contrast-enhanced CT scan were included study. Radiomics feature extraction was done after contoured. The...

10.1007/s00330-023-10090-8 article EN cc-by European Radiology 2023-08-11

The authors have successfully built and characterised a small animal PET based on 4 rotating detectors with spatial resolution <2 mm over its field of view sensitivity 640 cps//spl mu/Ci at the centre. scanner is four matrices 400 YAP:Ce finger crystals (2/spl times/2/spl times/30 mm/sup 3/ each) coupled to Position Sensitive PhotoMultipliers (Hamamatsu R2486-06.) now applied two high collimators opposite detectors, hence realising an integrated PET-SPECT for animals. are made lead 20 long,...

10.1109/23.873012 article EN IEEE Transactions on Nuclear Science 2000-08-01

A new scintillation detector system has been designed for application in high resolution positron emission tomography (PET). The is a bundle of small YAlO/sub 3/:Ce (YAP) crystals closely packed (0.2/spl times/0.2/spl times/3.0 cm/sup 3/), coupled to position sensitive photomultiplier tube (PSPMT). preliminary results obtained spatial resolution, time energy and efficiency 2 such detectors working coincidence are presented. These 1.2 mm the FWHM 2.0 ns 20% at 511 keV. measured (44/spl...

10.1109/23.507253 article EN IEEE Transactions on Nuclear Science 1996-06-01

Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of new myocardial perfusion tracer bis[(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine <i>N,N′</i>-bis(ethoxyethyl)dithiocarbamato nitrido technetium(V) (<sup>99m</sup>Tc-N-DBODC). <b>Methods:</b> Ten male were injected with <sup>99m</sup>Tc-N-DBODC under both stress rest conditions. Anterior posterior planar γ-camera images collected at 5, 30, 60, 240, 1,440 min after injection, organ...

10.2967/jnumed.108.053132 article EN Journal of Nuclear Medicine 2008-07-16
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