A5009276136- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Pneumocystis jirovecii pneumonia detection and treatment
- Frailty in Older Adults
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Prostate Cancer Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Polyomavirus and related diseases
- Glioma Diagnosis and Treatment
University of Ferrara
1996-2025
Azienda Unità Sanitaria Locale di Ferrara
2023
University of Brescia
2012-2022
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2014-2022
Arcispedale Sant'Anna
2015-2022
Terra
2022
Weatherford College
2022
Ospedale San Bortolo
2022
National Marrow Donor Program
2019
Università Cattolica del Sacro Cuore
2016
Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD).Ninety-four patients with GVHD (aGVHD) (n = 45) (cGVHD) 49), retrospectively recruited in 6 Italian centers, were submitted to ECP treatment. At the time of ECP, 22 (49%) 23 (51%) 45 aGHVD nonresponsive partial remission (PR) after steroids, respectively, all 49 cGVHD steroid refractory.Forty-one (91%) aGVHD achieved complete (CR) ECP. Fifteen (33%) developed...
Due to the discovery of their role in intra‑cellular communications, exosomes, which carry information specific cell origin, have garnered considerable attention cancer research. Moreover, there is evidence suggest possibility isolating different exosome sub‑populations based on target antigens at surface. Philadelphia chromosome‑positive (Ph+) chronic myeloid leukemia (CML) a clonal myeloproliferative neoplasia characterized by breakpoint cluster region‑proto‑oncogene 1 tyrosine‑protein...
Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that extensively used for the high-resolution of soft tissues. To obtain high-definition pictures tissues or whole organism this enhanced by use contrast agents. Gadolinium-based agents have an excellent safety profile. However, over last two decades, some specific concerns surfaced. Mn(II) has different favorable physicochemical characteristics and good toxicity profile, which makes it alternative to...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is burdened by life-threatening complications, with graft-versus-host disease (GvHD) being the major cause of morbility and mortality. Recently, clinical physiopathologic evidences showed that vascular endothelium can be a target GvHD in early phase circulating endothelial cells (CECs) represent surrogate markers damage.Using CellSearch System (Veridex LLC, Raritan, NJ), CECs were counted before (T1), after conditioning regimen...
A new scintillation detector system has been designed for application in high resolution positron emission tomography (PET). The is a bundle of small YAlO/sub 3/:Ce (YAP) crystals closely packed (0.2/spl times/0.2/spl times/3.0 cm/sup 3/), coupled to position sensitive photomultiplier tube (PSPMT). preliminary results obtained spatial resolution, time energy and efficiency 2 such detectors working coincidence are presented. These 1.2 mm the FWHM 2.0 ns 20% at 511 keV. measured (44/spl...
To evaluate if WT1 expression may predict relapse after allo-SCT, we analyzed levels on peripheral blood (PB) and bone marrow (BM) before allo-SCT in 24 AML patients with overexpression at diagnosis. Five copies of WT1/ABL × 10 4 from PB were identified as the threshold value that correlated allo-SCT. The same correlation was not when assessed (BM). Eight out 11 (73%) a pre-allo-SCT PB-WT1 ≥ 5 4/13 (31%) < relapsed, respectively ( P = 0.04). incidence higher measured 3rd (56% versus 38%;...
Real-time quantitative PCR (RT-qPCR) is the gold standard to quantify BCR-ABL1 transcript for molecular response monitoring in chronic myeloid leukemia (CML) patients, and it plays a pivotal role clinical decision-making process, even if presents technical limits. Increasing data suggest that digital (dPCR) more accurate reliable than RT-qPCR CML minimal residual disease patients' selection treatment discontinuation. But what about identification of discontinuation failures? We present case...
CMV infection is a major challenge in allogeneic stem cell transplantation (allo-SCT). The changing landscape management includes the introduction of letermovir prophylaxis high-risk patients and source DNA monitoring (plasma-PL vs. whole blood-WB), for pre-emptive therapy (PET) initiation. We report here how our real-life experience evolved, following registration. focus on: (i) effects systematic use patients, (ii) results longitudinal comparison DNAemia PL WB. From December 2018 to April...
Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for infection prevention management has been used our centre since 2019. specific features the protocol regard both prophylaxis during neutropenia (abandonment fluoroquinolone, posaconazole use high-risk patients, aerosolized liposomal amphotericin B until...
Exosomes are extracellular vesicles playing a pivotal role in the intercellular communication. They shuttle different cargoes, including nucleic acids from their cell of origin. For this reason, they have been studied as carriers tumor markers liquid biopsy approaches, particular for solid tumors. Few data available concerning exosomes myeloid neoplasia. To better understand real potential and best approach to investigate leukemic exosomes, we present results pilot feasibility study...
Oligometastatic patients at [18F]F-Fluorocholine (18F-choline) PET/CT may be treated with metastasis-directed therapy (MDT). The aim of this study was to combine radiomic parameters extracted from 18F-choline and clinical data build machine learning (ML) models able predict MDT efficacy. Methods: Oligorecurrent (≤5 lesions) were collected. A per-patient per-lesion analysis performed, using 2-year biochemical recurrence (BCR) after as the standard reference. Clinical features (RFts) used for...
T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with neogenesis indexes has thoroughly analysed in relation these changing interrelated immunologic/clinic events yet. Lymphocyte peripheral blood (PB) were at different time points a prospective study 50 patients. Principal component analysis (PCA) was used as first step...
To evaluate the relevance of incidental prostate [18F]FDG uptake (IPU) and to explore potential radiomics machine learning (ML) predict cancer (PCa).We retrieved PET/CT scans with evidence IPU performed in two institutions between 2015 2021. Patients were divided into PCa non-PCa, according biopsy. Clinical PET/CT-derived information (comprehensive radiomic analysis) acquired. Five ML models developed their performance discriminating vs non-PCa was evaluated. Radiomic analysis investigated...
Monte Carlo (MC) simulation in Nuclear Medicine is a powerful tool for modeling many physical phenomena which are difficult to track or measure directly. MC SPECT/CT imaging particularly suitable optimizing the quantification of activity patient, and, consequently, absorbed dose each organ. To do so, validating results with real data acquired gamma camera mandatory. The aim this study was validation calibration factor (CF) and recovery coefficient (RC) obtained SIMIND code Siemens Symbia...
Toll-like receptors (TLRs) play a key role in the cross-talk between innate and adaptive immune systems. Previous studies investigating associations certain TLRs acute graft-versus-host disease (aGVHD) have reported contrasting results, no relating aGVHD to expression function of all human together been published date. We prospectively evaluated 9 on T lymphocytes monocytes by flow cytometry relation 34 patients. Induction TNF-α, IL-4, IFN-γ, monocyte chemotactic protein 1 TLR activation was...
Myelodysplastic syndromes and acute leukemias after allogeneic stem cell transplantation (allo-SCT) are mainly caused by recurrence of the primitive leukemic clones. More rarely, they originate from donor hematopoietic cells, developing so-called leukemia (DCL) or myelodysplastic (DC-MDSs). DCL DC-MDS can be considered as an in vivo model leukemogenesis, even if pathogenetic mechanisms remain speculative, a genetic predisposition progenitor altered host microenvironment, impairment immune...
Abstract Background Bacterial, fungal, and viral infections often affect non‐relapse mortality after allogeneic stem cell transplantation (allo SCT ). Recovery from depends on a balanced integration between innate adaptive immune responses. In this complex interplay, key role is played by Toll‐like receptors ( TLR s), which are sensors of pathogen‐associated molecular patterns. To our knowledge, no previous study deals with both expression function all human s together, in relation to the...
The aim of this study was to estimate the radioactive risk for surgical staff performing radioguided sentinel lymph node (SN) biopsy and calculate contamination level in operating room assessment possible need specific radiation protection procedures. We studied 20 patients who were selected quadrantectomy SN biopsy. day before surgery a volume 0.15 mL 99mTc-nanocoll injected: activity 3.11 +/- 0.85 MBq group A (15 pts) 11.6 0.6 B (5 pts). External evaluated by measuring exposure rate air...