A5024225840- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cancer, Hypoxia, and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Metabolism, Diabetes, and Cancer
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Prostate Cancer Treatment and Research
- Coronary Interventions and Diagnostics
- Alzheimer's disease research and treatments
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- MRI in cancer diagnosis
- Vasculitis and related conditions
- Ultrasound and Hyperthermia Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Pancreatic function and diabetes
University of Genoa
2016-2025
Ospedale Policlinico San Martino
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2024
University of Oslo
2022
Universitair Ziekenhuis Brussel
2022
Institut de Recherche pour le Développement
2022
Oslo University Hospital
2022
Turku University Hospital
2022
Inserm
2022
European Society of Cardiology
2022
Background — Depressed myocardial blood flow (MBF) has been reported in dilated cardiomyopathy. The aim of this study was to investigate whether MBF impairment is an independent predictor prognosis patients with idiopathic left ventricular (LV) dysfunction. Methods and Results Sixty-seven (52 male, mean age 52±12 years) different degrees LV systolic dysfunction (average ejection fraction, 0.34±0.10; range, 0.07 0.49) were prospectively enrolled. Thirty-four subjects (51%) had no history...
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
Dendritic cells (DC) are highly specialized antigen-presenting characterized by the ability to prime T-cell responses. Mesenchymal stem (MSC) adult stromal progenitor displaying immunomodulatory activities including inhibition of DC maturation in vitro. However, specific impact MSC on functions, upon vivo administration, has never been elucidated. Here we show that murine impair Toll-like receptor-4 induced activation resulting cytokines secretion, down-regulation molecules involved...
Background Myocardial blood flow (MBF) impairment has been documented in advanced dilated cardiomyopathy (DCM) which hemodynamic factors, secondary to severe ventricular dysfunction, may limit myocardial perfusion. To assess whether MBF DCM also be present independent of the study was designed quantify perfusion patients with mild disease without overt heart failure. Methods and Results Absolute regional (milliliters per minute gram) measured by positron emission tomography 13 N-ammonia...
Cancer stem cell theory postulates that a small population of tumor-initiating cells is responsible for the development, progression and recurrence several malignancies, including glioblastoma. In this perspective, represent most relevant target to obtain effective cancer treatment. Metformin, first-line drug type II diabetes, was reported possess anticancer properties affecting survival in breast models. We report metformin treatment reduced proliferation rate cell-enriched cultures...
Tumor chemoresistance is associated with high aerobic glycolysis rates and reduced oxidative phosphorylation, a phenomenon called "Warburg effect" whose reversal could impair the ability of wide range cancer cells to survive in presence or absence chemotherapy. In previous studies, Short-term-starvation (STS) was shown protect normal organs but sensitize different cell types chemotherapy mechanisms responsible for these effects are poorly understood. We tested cytotoxicity Oxaliplatin (OXP)...
Cardiovascular events remain one of the most frequent causes mortality and morbidity worldwide. The majority cardiac occur in individuals without known coronary artery disease (CAD) low- to intermediate-risk subjects. Thus, development improved preventive strategies may substantially benefit from identification, among apparently subjects, those who have a high probability for developing future events. Cardiac computed tomography myocardial perfusion scintigraphy (MPS) by single photon...
Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In present study, we demonstrate metformin directly inhibits enzymatic function hexokinase (HK) I II cell line triple-negative breast cancer (MDA-MB-231). The inhibition is selective for these isoforms, as documented by experiments with purified HK well lysates. Measurements (18)F-fluoro-deoxyglycose uptake document it dose- time-dependent powerful...
This project aimed to investigate the metabolic basis for resilience neurodegeneration (cognitive reserve) in highly educated patients with prodromal Alzheimer disease (AD).Sixty-four amnestic mild cognitive impairment who later converted AD dementia during follow-up, and 90 controls, underwent brain (18)F-FDG PET. Both groups were divided into a poorly subgroup (42 controls 36 patients) (48 28 patients). Brain metabolism was first compared between education-matched of controls. Then, both...
The anti-hyperglycaemic drug metformin has important anticancer properties as shown by the direct inhibition of cancer cells proliferation. Tumor avidly use glucose a source for energy production and cell building blocks. Critical to this phenotype is glucose-6-phosphate (G6P), catalysed hexokinases (HK) I II, whose role in retention metabolism highly advantageous survival Here we show that impairs enzymatic function HKI II Calu-1 cells. This virtually abolishes uptake phosphorylation...
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
Metastasis-directed therapy (MDT) has been tested in clinical trials as a treatment option for oligorecurrent prostate cancer (PCa). However, there is an ongoing debate regarding the impact of using different imaging techniques interchangeably defining lesions and guiding MDT within trials. <b>Methods:</b> We retrospectively identified PCa patients who had 5 or fewer nodal, bone, visceral metastases detected by choline prostate-specific membrane antigen (PSMA) PET/CT underwent stereotactic...
The present investigation was designed to obtain an absolute measurement of myocardial blood flow and its transmural distribution in ischemic heart disease idiopathic dilated cardiomyopathy provide a reference standard for cardiac imaging nuclear cardiology.Regional were estimated by the microsphere method eight patients with (n = 4) or during transplant procedure. Before aortic clamping, 99mTc-labeled human albumin microspheres injected into left atrium while arterial sampled from aorta at...
To unveil cognitive-nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug-naïve PD patients and 15 with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery brain SPECT [I-123]Ioflupane, as biomarker of nigrostriatal function. Automatic extraction uptake at caudate putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because multicollinearity among tests variables, factor analysis applied to 16...
An emerging issue in neuroimaging is to assess the diagnostic reliability of PET and its application clinical practice. We aimed at assessing accuracy brain FDG-PET discriminating patients with MCI due Alzheimer's disease healthy controls. Sixty-two amnestic 109 subjects recruited five centers European AD Consortium were enrolled. Group analysis was performed by SPM8 confirm metabolic differences. Discriminant analyses then carried out using mean FDG uptake values normalized cerebellum...
Abstract Cancer metabolism is characterized by an accelerated glycolytic rate facing reduced activity of oxidative phosphorylation. This “Warburg effect” represents a standard to diagnose and monitor tumor aggressiveness with 18 F-fluorodeoxyglucose whose uptake currently regarded as accurate index total glucose consumption. Studying cancer metabolic response respiratory chain inhibition metformin, we repeatedly observed reduction tracer marked increase in puzzling discordance brought us...
Several studies have highlighted the role of vascular (18)F-NaF uptake as a marker ongoing calcium deposition. However, accumulation is often inconsistent with localization arterial plaque. Calcification activity and thus might prevail in earlier plaque stages. To test this hypothesis, we evaluated 3 different densities, using density calcification progression. We also tested whether attenuation-weighted image reconstruction affects stages.Sixty-four oncologic patients (14 men 50 women; mean...