A5042887533- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Infective Endocarditis Diagnosis and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Orthopedic Infections and Treatments
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Medical Imaging and Pathology Studies
- Viral Infections and Immunology Research
- Parathyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Radiation Dose and Imaging
- Cardiomyopathy and Myosin Studies
- Cell Adhesion Molecules Research
- Neuroblastoma Research and Treatments
- Infectious Aortic and Vascular Conditions
- Cardiac Structural Anomalies and Repair
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Santé Publique France
2023
Hôpital Bichat-Claude-Bernard
2012-2022
Assistance Publique – Hôpitaux de Paris
2012-2022
Inserm
2012-2021
Université Paris Cité
2012-2021
Laboratoire de Recherche Vasculaire Translationnelle
2014-2021
Université Paris-Saclay
2010-2021
European Council
2021
Institut de Radioprotection et de Sûreté Nucléaire
2020
Université Claude Bernard Lyon 1
2009-2019
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
Echocardiography plays a key role in the diagnosis of infective endocarditis (IE) but can be inconclusive patients whom prosthetic valve (PVE) is suspected. The incremental diagnostic value <sup>18</sup>F-FDG PET and radiolabeled leukocyte scintigraphy IE has already been reported. aim this study was to compare respective performance for PVE 39 patients. <b>Methods:</b><sup>18</sup>F-FDG were performed on consecutive admitted because clinically suspected echocardiography results. results...
P-selectin expression is involved in the pathophysiology of biologically active arterial thrombus and endothelial activation after a transient ischemic event. Fucoidan polysaccharidic ligand P-selectin, with nanomolar affinity. In present study, we propose new approach molecular imaging based on radiolabeled fucoidan. <b>Methods:</b> Two kinds experimental models were selected to evaluate ability fucoidan detect expression: platelet-rich thrombi (vegetations infective endocarditis mural...
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
The potential risks associated with cardiovascular imaging (CVI) have recently been debated, partly triggered by the rapid increase in use of procedures and new modalities such as cardiac computed tomography (CT).1,2 discussion has mainly focused only on a single-risk aspect radiation.3 However, various several risks: stressors, contrast agents, invasiveness, radiation, etc. Even more important, test must be related to benefit performing or not risk drawbacks disease remaining...
18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been recently acknowledged as a diagnostic tool for prosthetic valve endocarditis, but its specificity is limited by uptake on noninfected valves. The objective of this study was to outline the main features FDG PET/CT in patients with heart (PHV).Our institution's database reviewed identify PHV, excluding those suspected infection or who had received antibiotic treatment. PET indication, location, and...
We assessed the potential benefits of including systematic 18fluorodeoxyglucose positron emission tomography (FDG-PET) for detecting tumour recurrence in a prospective randomised trial. Patients (N=130) who had undergone curative therapy were to undergo either conventional (Con) or FDG-PET procedures during follow-up. The two groups matched at baseline. Recurrence was confirmed histologically. 'Intention-to-treat' analysis revealed 46 patients (25 group, and 21 Con group; P=0.50), whereas...
Abstract Development and progression of acquired abdominal aortic aneurysms (AAAs) involve proteolytic activity. In the present study, we investigate distribution fibrinolytic system components within mural thrombi human AAAs. 20 remaining AAA walls were dissected. The luminal, intermediate abluminal thrombus layers, media adventitia separately incubated in cell culture medium. Conditioned then analysed for plasminogen activators (PAs), activator inhibitor‐1 (PAI‐1), free‐plasmin, plasmin α...
In patients with a suspicion of prosthetic valve endocarditis (PVE), detection perivalvular infection can be difficult based only on echocardiography. The aim this retrospective study was to test the interest radiolabelled leucocyte scintigraphy (LS) for in PVE and inconclusive transoesophageal echocardiography (TEE). LS performed 42 patients. results were classified as positive cardiac area (intense or mild), negative. Macroscopical aspects bacteriology obtained from who underwent surgery...
Dose kernel convolution (DK) methods have been proposed to speed up absorbed dose calculations in molecular radionuclide therapy. Our aim was evaluate the impact of tissue density heterogeneities (TDH) on dosimetry when using a DK method and propose simple density-correction method. <b>Methods:</b> This study has conducted 3 clinical cases: case 1, non-Hodgkin lymphoma treated with <sup>131</sup>I-tositumomab; 2, neuroendocrine tumor treatment simulated <sup>177</sup>Lu-peptides; 3,...
Cardiac implantable electronic devices (CIEDs) chronic infection diagnosis is challenging because the clinical presentation frequently misleading and echocardiography may be inconclusive. The aim of this study was to evaluate diagnostic value 18F-fluorodeoxyglucose positron emission tomography/computed tomography (CT) radiolabeled white blood cells single photon CT/CT in a cohort patients who underwent both scans for suspicion CIED inconclusive routine investigations.Forty-eight consecutive...
Background: Human complement factor H-related protein (hCFHrp) is produced by several bladder cancer cell lines and may be useful as a marker. The aim of this study was to compare urinary hCFHrp cytology for the detection found cystoscopy in patients with suggestive signs, symptoms, or preliminary test results. Methods: BTA TRAKTM assay, quantitative enzyme immunoassay tumor-associated antigen urine, compared exfoliative 220 (155 men, 65 women; mean age, 64.2 years) presenting diagnostic...
BACKGROUND: Reflux oesophagitis is considered a multifactorial disease, but the respective roles of main factors involved in its pathophysiology have not been clearly established. AIMS: To attempt to assign these by means multivariate logistic regression analysis parameters associated with reflux oesophagitis. PATIENTS: Eighty seven patients gastro-oesophageal disease were studied: 41 without and 46 grade 1 3. METHODS: (1) Monovariate comparison patients9 characteristics derived from...
Background Fibrosis, which is characterized by the pathological accumulation of collagen, recognized as an important feature many chronic diseases, and such, constitutes enormous health burden. We need non-invasive specific methods for early diagnosis follow-up fibrosis in various disorders. Collagen targeting molecules are therefore interest potential vivo imaging fibrosis. In this study, we developed a collagen-specific probe using new approach that takes advantage inherent specificity...