A5088603129- Infective Endocarditis Diagnosis and Management
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Cardiac Valve Diseases and Treatments
- Infectious Aortic and Vascular Conditions
- Systemic Lupus Erythematosus Research
- Cardiac tumors and thrombi
- Atherosclerosis and Cardiovascular Diseases
- Otitis Media and Relapsing Polychondritis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Cardiac Structural Anomalies and Repair
- Pericarditis and Cardiac Tamponade
- Aortic Disease and Treatment Approaches
- IgG4-Related and Inflammatory Diseases
- Osteomyelitis and Bone Disorders Research
- Lung Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Bichat-Claude-Bernard
2016-2025
Université Claude Bernard Lyon 1
2015-2025
Université Paris Cité
2015-2024
Inserm
2013-2022
Centre universitaire de médecine générale et santé publique, Lausanne
2016-2022
Institut National de Nutrition et de Technologie Alimentaire
2020-2021
Délégation Paris 7
2012-2020
Institut National d'Oncologie
2020
Sorbonne Paris Cité
2012-2019
Echocardiography plays a key role in the diagnosis of infective endocarditis (IE) but can be inconclusive patients whom prosthetic valve (PVE) is suspected. The incremental diagnostic value <sup>18</sup>F-FDG PET and radiolabeled leukocyte scintigraphy IE has already been reported. aim this study was to compare respective performance for PVE 39 patients. <b>Methods:</b><sup>18</sup>F-FDG were performed on consecutive admitted because clinically suspected echocardiography results. results...
The use of 18F-fluoro-deoxyglucose positron emission tomography scan (FDG-PET) and computed angiography (CTA) to improve accuracy diagnosis giant cell arteritis (GCA) is a very important clinical need. We aimed compare the diagnostic performance FDG-PET CTA in patients with GCA. were acquired all consecutive suspected for Results compared final based on judgment, temporal artery biopsy (TAB) findings, ACR criteria. Sensitivity, specificity, positive negative predictive values (PPV, NPV)...
18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been recently acknowledged as a diagnostic tool for prosthetic valve endocarditis, but its specificity is limited by uptake on noninfected valves. The objective of this study was to outline the main features FDG PET/CT in patients with heart (PHV).Our institution's database reviewed identify PHV, excluding those suspected infection or who had received antibiotic treatment. PET indication, location, and...
In patients with a suspicion of prosthetic valve endocarditis (PVE), detection perivalvular infection can be difficult based only on echocardiography. The aim this retrospective study was to test the interest radiolabelled leucocyte scintigraphy (LS) for in PVE and inconclusive transoesophageal echocardiography (TEE). LS performed 42 patients. results were classified as positive cardiac area (intense or mild), negative. Macroscopical aspects bacteriology obtained from who underwent surgery...
Cardiac implantable electronic devices (CIEDs) chronic infection diagnosis is challenging because the clinical presentation frequently misleading and echocardiography may be inconclusive. The aim of this study was to evaluate diagnostic value 18F-fluorodeoxyglucose positron emission tomography/computed tomography (CT) radiolabeled white blood cells single photon CT/CT in a cohort patients who underwent both scans for suspicion CIED inconclusive routine investigations.Forty-eight consecutive...
The purpose of this study was to assess the prognostic value <sup>18</sup>F-FDG PET parameter variation between baseline and 42 Gy (PET2) radiochemotherapy at 6 mo 1 y evaluation in patients with stage III inoperable nonsmall cell lung cancer based on RECIST 1.1. <b>Methods:</b> In total, 158 a prospective multicenter phase II/III were analyzed. Patients randomized into 2 groups: an experimental arm (group A) standard B). from group A residual metabolism PET2 A+) received radiation boost (74...
The role of B cells in the pathogenesis Takayasu arteritis (TA) is controversial. We aimed to study presence tertiary lymphoid organs (TLOs) aortic wall TA patients.Hematoxylin and eosin-stained sections from aorta specimens patients with were screened for TLOs. cell aggregates (CD20), follicular dendritic (FDCs, CD21), high endothelial venules (HEVs, PNAd) was investigated by immunohistochemistry. Immune adventitial layer one patient characterized flow cytometry. Demographic, medical...
Hydrazinonicotinamide–annexin A5 (HYNIC-Anx), a 99m technetium ( Tc)-labeled agent targeting phosphatidylserine, proved to be sensitive for the detection of apoptosis and thrombosis but is no longer available clinical use. A mutant human annexin designed direct Tc labeling (referred as Anx A5–128) showed improved binding affinity phosphatidylserine expected used in humans. We compared both radiotracers with regard pharmacokinetics diagnostic ability animal models. Biodistribution studies...
Introduction Steroids and anti-IL6 biotherapy are highly effective in obtaining remission patients with giant cell arteritis (GCA) but the risk of relapses remains high. We aimed to identify predictors relapse GCA. Methods All consecutive admitted a new diagnosis GCA - according 2022 American College Rheumatology/EULAR (ACR/EULAR) classification criteria between May 2011 were eligible for this study. The primary outcome was rate over 36-months follow up. Factors associated time first...
Radiolabeled phosphatidylserine (PS)-binding peptides represent an innovative strategy for molecular imaging of apoptosis and thrombus. The hexapeptide PGDLSR was described as a selective high affinity ligand PS. In this work, we synthesized evaluated gallium labelled-PGDLSR peptide potential radiopharmaceutical nuclear imaging. PGDLSR-β-alanine-NODAGA (P04087) prepared using Fmoc-based synthesis then chelated with cold gallium, 68Ga 67Ga. Ga-P04087 PS by competitive binding assay...