A5000308347- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Photoacoustic and Ultrasonic Imaging
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Ultrasound in Clinical Applications
- Ultrasound Imaging and Elastography
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Ultrasound and Cavitation Phenomena
- Neurogenetic and Muscular Disorders Research
- Cardiovascular and Diving-Related Complications
- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Congenital heart defects research
Erasmus MC
2012-2024
Erasmus University Rotterdam
2008-2022
St. Antonius Ziekenhuis
2005-2015
KU Leuven
2015
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2014
Loyola University Chicago
2011-2013
Amsterdam UMC Location University of Amsterdam
2013
Haga Hospital
2013
University Medical Center
2011-2013
University Hospital and Clinics
2013
Mutations in the MYBPC3 gene, encoding cardiac myosin-binding protein C (cMyBP-C), are a frequent cause of familial hypertrophic cardiomyopathy. In present study, we investigated whether composition and function sarcomere altered homogeneous cardiomyopathy patient group with frameshift mutations (MYBPC3(mut)).Comparisons were made between samples from mutant carriers (c.2373dupG, n=7; c.2864_2865delCT, n=4) nonfailing donors (n=13). Western blots use antibodies directed against cMyBP-C did...
Aims To assess the agreement of left ventricular ejection fraction (LVEF) determinations from unenhanced echocardiography, contrast-enhanced magnetic resonance imaging (MRI), and cineventriculography as well inter-observer for each method. Methods results In 120 patients, with evenly distributed EF-groups (>55, 35–55, <35%), cineventriculography, echocardiography second harmonic imaging, contrast at low mechanical index iv administration SonoVue® were performed. addition, cardiac MRI 1.5 T...
<b>Objectives:</b> To investigate diagnostic routes, echocardiographic substrates, outcomes and prognostic factors in patients with isolated ventricular non-compaction (IVNC) identified by laboratories referral from specialists primary care physicians. <b>Patients design:</b> Since 1991, all suspected IVNC were flagged followed up on dedicated databases. Patients divided into symptom-based non-symptom-based subgroups. <b>Results:</b> 65 eligible for 6–193 months (mean 46 (SD 44). In 53 (82%)...
Left ventricular (LV) noncompaction (LVNC) is a distinct cardiomyopathy featuring thickened bilayered LV wall consisting of thick endocardial layer with prominent intertrabecular recesses thin, compact epicardial layer. Similar to hypertrophic and dilated cardiomyopathy, LVNC genetically heterogeneous was recently associated mutations in sarcomere genes. To contribute the genetic classification for LVNC, systematic cardiological family study performed cohort 58 consecutively diagnosed...
Ischemia occurs frequently in hypertrophic cardiomyopathy (HCM) without evidence of epicardial stenosis. This study evaluates the hypothesis that occurrence ischemia HCM is related to remodeling coronary microcirculation.End-diastolic septal wall thickness was significantly increased patients with (25.8+/-2.9 mm) comparison cardiac transplant recipients (control subjects: 11.4+/-3.0 mm; P<0.05). Although diameter left anterior descending artery similar both groups (3.0+/-0.8 versus 3.0+/-0.5...
The impact of alcohol septal ablation (ASA)-induced scar is not known. This study sought to examine the long-term outcome ASA among patients with obstructive hypertrophic cardiomyopathy.Ninety-one consecutive (aged 54+/-15 years) cardiomyopathy underwent ASA. Primary end point was a composite cardiac death and aborted sudden including appropriate cardioverter-defibrillator discharges for fast ventricular tachycardia/ventricular fibrillation. Secondary points were noncardiac other nonfatal...
High-myofilament Ca(2+) sensitivity has been proposed as a trigger of disease pathogenesis in familial hypertrophic cardiomyopathy (HCM) on the basis vitro and transgenic mice studies. However, myofilament depends protein phosphorylation muscle length, at present, data humans are scarce.To investigate whether high perturbed length-dependent activation characteristics for human HCM with mutations thick thin filament proteins.Cardiac samples from patients harboring genes encoding (MYH7,...
The tricuspid valve (TV) is a complex structure. Unlike the aortic and mitral it not possible to visualize all TV leaflets simultaneously in one cross-sectional view by standard two-dimensional echocardiography (2DE) either transthoracic or transesophageal due position of far field.Quantitative qualitative assessment normal using real-time 3-dimensional (RT3DE).RT3DE was performed for 100 adults (mean age 30 +/- 9 years, 65% males). RT3DE visualization evaluated 4-point score (1: visualized,...
Background— The recently released 2014 European Society of Cardiology guidelines hypertrophic cardiomyopathy (HCM) use a new clinical risk prediction model for sudden cardiac death (SCD), based on the HCM Risk-SCD study. Our study is first external and independent validation this model. Methods Results— population consisted consecutive cohort 706 patients with without prior SCD event, from 2 tertiary referral centers. primary end point was composite appropriate implantable...
Hypertrophic cardiomyopathy (HCM), typically characterized by asymmetrical left ventricular hypertrophy, frequently is caused mutations in sarcomeric proteins. We studied if changes properties HCM depend on the underlying protein mutation.Comparisons were made between cardiac samples from patients carrying a MYBPC3 mutation (MYBPC3(mut); n=17), negative without an identified sarcomere (HCM(mn); n=11), and nonfailing donors (n=12). All had normal systolic function, but impaired diastolic...