A new optical characterization of the behavior single ultrasound contrast bubbles is presented. The method consists insonifying individual several times successively sweeping applied frequency, and to record movies bubble response up 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. method, termed microbubble spectroscopy, enables reconstruct resonance curve run. data analyzed through linearized model for coated bubbles. results confirm significant influence...

Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved remarkably over the past three decades. Initially designed to enhance contrast in ultrasound imaging, microbubbles have emerged as main vector for offering targeted therapy with minimized side effects. This review addresses historical progression of this technology, emphasizing pivotal role play augmenting extravasation and delivery. We explore complex mechanisms behind from stable inertial cavitation diverse...

The field of contrast echography traces its origin to the work first published in 1968. With introduction UCA, it was thought that would be sufficient detect and image them with conventional imaging methods nowadays referred as fundamental imaging. It is currently believed special hard- software development required will result newer techniques, which more sensitive based on specific properties UCA. Taking advantage acoustic bubbles has made different feasible like harmonic B-mode imaging,...

Doxorubicin is a potent chemotherapeutic whose severe side effects limit its application. Drug-targeted delivery with noninvasive techniques required to increase the drug concentration locally and reduce systemic effects. Microbubble-assisted ultrasound has become promising strategy for local delivery. The aim of this study evaluate applicability effectiveness administration doxorubicin combined microbubble-assisted in human U-87MG glioblastoma MDA-MB-231 breast cancer cells. In present...

Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering low bioavailability, high cytotoxicity, and undesirable side effects some clinical drugs. Targeted delivery sustained release therapeutic drugs to cells can reduce whole-body cytotoxicity agent deliver safe localized treatment patient. There is growing interest herbal drugs, such as curcumin, which highly noted promising anti-tumor drug, its wide range bioactivities properties against various...

There are numerous experimental investigations on sonoporation, while the theoretical background of this phenomenon still is in its infancy. One suggested mechanisms sonoporation linked to shear stress exerted cell membrane by acoustic microstreaming generated a contrast microbubble pulsating nearby cell. Currently, existing model effect based an equation that has been derived for free hemispherical bubble resting rigid plane. Such not adequate microbubble. In paper, improved theory assumes...

Targeted drug delivery under image guidance is gaining more interest in the drug-delivery field. The use of microbubbles as contrast agents diagnostic ultrasound provides new opportunities noninvasive image-guided delivery. In present study, imaging and therapeutic properties novel doxorubicin liposome-loaded are evaluated. results showed that at scanning settings (1.7 MHz mechanical index 0.2), these scatter sufficient signal for nonlinear can thus be imaged real time tracked vivo. vitro...

Coded excitation is currently used in medical ultrasound to increase signal-to-noise ratio (SNR) and penetration depth. We propose a chirp method for contrast agents using the second harmonic component of response. This based on compression filter that selectively compresses extracts from received echo signal. Simulations have shown clear response over pulse with same peak amplitude. was confirmed by two-dimensional (2-D) optical observations bubble fast framing camera. To evaluate method,...

The problem of acoustic microstreaming that develops around a gas bubble in an ultrasound field is considered. It shown the solutions obtained previously by Wu and Du [(1997). J. Acoust. Soc. Am. 101, 1899–1907], which are based on assumption viscous effects essential only within thin boundary layer while beyond liquid can be considered to inviscid, lead severe underestimation power streaming. An improved theory suggested corrects errors previous extends its limits. proposed treats entire...

Thin solid shell contrast agents bubbles are expected to undergo different volume oscillating behaviors when the acoustic power is increased: small oscillations remains spherical, and large buckles. Contrary covered with thin lipidic monolayers that buckle as soon compressed: resist compression, making buckling transition abrupt. Numerical simulations explicitly incorporate a bending modulus give critical pressure post-buckling shape, show appearance of finite number wrinkles. These findings...

Interest in the problem under consideration this study is motivated by targeted ultrasound imaging where one has to deal with microbubble contrast agents pulsating near blood vessel walls. A modified Rayleigh–Plesset equation derived that describes oscillation of a agent an elastic wall finite thickness. It assumed medium behind fluid but it shown obtained easily transformable case solid. In model rigid wall, which predicts decreasing natural frequency bubble reveals can both decrease and...