A5010359444- Ultrasound and Hyperthermia Applications
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Microbial Inactivation Methods
- vaccines and immunoinformatics approaches
- Cancer Research and Treatments
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Electrospun Nanofibers in Biomedical Applications
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Adenosine and Purinergic Signaling
- Inhalation and Respiratory Drug Delivery
Ghent University
2016-2025
Ghent University Hospital
2011-2024
Cancer Research Institute Ghent
2017-2024
Université Paris Cité
2019
University of Coimbra
2019
University of Twente
2019
Drug delivery with microbubbles and ultrasound is gaining more attention in the drug field due to its noninvasiveness, local applicability, proven safety ultrasonic imaging techniques. In this article, we tried improve cytotoxicity of doxorubicin (DOX)-containing liposomes by preparing DOX-liposome-containing for therapeutic ultrasound. way, DOX release uptake can be restricted ultrasound-treated areas. Compared DOX-liposomes, DOX-loaded killed at least two times melanoma cells after...
Ultrasound imaging is widely used in both diagnosis of diseases and pregnancy follow-up. As ultrasound a harmless, cheap portable technique, guided drug delivery gaining more attention the field. To be effective, most cases, ultrasonic makes use microbubbles. This highlight describes why it attractive to load microbubbles with drugs discusses recent attempts made design loaded
Ultrasound in combination with microbubbles has recently been considered by gene delivery scientists to be an interesting approach enhance transfer into cells. Its low toxicity and simplicity apply vivo without major complications make this technology (sonoporation) especially attractive. Sonoporation of DNA evaluated the injection free plasmid (pDNA) together (as used diagnostic imaging) bloodstream. However, gene-transfer efficiency these experiments remained rather low. Both enzymatic...
There is a great interest in delivering macromolecular agents into living cells for therapeutic purposes, such as siRNA gene silencing. Although substantial effort has gone designing nonviral nanocarriers macromolecules cells, translocation of the molecules from endosomes after endocytosis cytoplasm remains major bottleneck. Laser-induced photoporation, especially combination with gold nanoparticles, an alternative physical method that receiving increasing attention cells. By allowing...
Cancer vaccines based on mRNA are extensively studied. The fragile nature of has instigated research into carriers that can protect it from ribonucleases and as such enable its systemic use. However, carrier-mediated delivery been linked to production type I interferon (IFN) was reported compromise the effectiveness vaccines. In this study, we evaluated a cationic lipid for encapsulation mRNA. nanometer-sized, negatively charged particles (LMPs) efficiently transfected dendritic cells...
Abstract Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite high mortality rate and increasing antibiotic resistance no clinically approved vaccine against available. Attenuated strains offer protection are tested as antitumor vectors, but would benefit from better knowledge on immunodominant vector antigens. To identify novel antigens, we screen for peptides presented the surface of infected cell lines by mass spectrometry-based...
Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by blood-brain barrier (BBB). Several approaches have been used overcome this hindrance facilitate treatment various CNS diseases. We now present results showing that chimeric adeno-associated virus 2/1 (AAV2/1) particles containing coding region for LacZ gene are efficiently delivered into rat brain upon intravenous (IV) administration after BBB opening focused ultrasound in presence vascular acoustic...