A5039589438- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Laser-Ablation Synthesis of Nanoparticles
- Microfluidic and Bio-sensing Technologies
- Fluid Dynamics and Mixing
- Gold and Silver Nanoparticles Synthesis and Applications
- Ultrasonics and Acoustic Wave Propagation
- Fluid Dynamics and Heat Transfer
- Nanoplatforms for cancer theranostics
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Pickering emulsions and particle stabilization
- Nanoparticle-Based Drug Delivery
- Microbial Inactivation Methods
- Laser-induced spectroscopy and plasma
- Gas Dynamics and Kinetic Theory
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fluid Dynamics and Vibration Analysis
- Micro and Nano Robotics
- Surface Modification and Superhydrophobicity
- Acoustic Wave Phenomena Research
- Atomic and Subatomic Physics Research
- Aerosol Filtration and Electrostatic Precipitation
Max Planck University of Twente Center for Complex Fluid Dynamics
2018-2025
University of Twente
2016-2025
Chan Heart Rhythm Institute
2021
Erasmus University Rotterdam
2017-2021
Erasmus MC
2017-2021
University of Coimbra
2019
Abnoba (Germany)
2019
Ghent University
2019
Université Paris Cité
2019
Ghent University Hospital
2019
Reproduction of the anatomical structures and functions tissues using cells designed 3D scaffolds is an ongoing challenge. For this, with appropriate biomorphic surfaces promoting cell attachment, proliferation differentiation are needed. In this study, eight triply-periodic minimal surface (TPMS)-based were specific trigonometric equations, providing same porosity number unit cells, while presenting different curvatures. The fabricated by stereolithography a photocurable resin based on...
Significance Plasmonic microbubbles are at the center of numerous applications, including micromanipulation/nanomanipulation, biomedical diagnosis and therapy, solar energy harvesting. Controlling dynamics these is key to successfully exploiting their potential in growing number applications. Literature has vastly overlooked nucleation early microsecond by which arise. It utmost importance understand this phase, as it displays most violent precursor origin all subsequent dynamics, on many...
Microbubbles are of great interest both for ultrasound imaging and ultrasound-assisted therapy due to their nonlinear scattering, which is enhanced by the viscoelastic shell. A full characterization this response therefore crucial fully exploit potential. Current microbubble techniques rely on assumptions regarding shell rheology. Here, a stress-strain method proposed characterize shells single microbubbles with minimal underlying assumptions, mainly entail separable viscous elastic...
Ultrasound is the most commonly used clinical imaging modality. However, in applications requiring cell-labeling, large size and short active lifetime of ultrasound contrast agents limit their longitudinal use. Here, 100 nm radius, clinically applicable, polymeric nanoparticles containing a liquid perfluorocarbon, which enhance during repeated over course at least 48 h, are described. The perfluorocarbon enables monitoring with quantitative 19F magnetic resonance imaging, making these...
Understanding the ultrasound pressure-driven dynamics of microbubbles confined in viscoelastic materials is relevant for multiple biomedical applications, ranging from contrast-enhanced imaging to ultrasound-assisted drug delivery. The volumetric oscillations spherical bubbles are analyzed using Rayleigh-Plesset equation, which describes conservation mass and momentum surrounding medium. Several studies have considered an extension equation embedded into media, but these restricted a...
Under continuous laser irradiation, noble metal nanoparticles immersed in water can quickly heat up, leading to the nucleation of so-called plasmonic bubbles. In this work, we want further understand bubble and growth mechanism. particular, quantitatively study effect amount dissolved air on dynamics, both for initial giant bubble, which forms shortly after switching is mainly composed vapor, final life phase during it contains expelled from water. We found that temperature depends gas...
Sonoporation is the process where intracellular drug delivery facilitated by ultrasound-driven microbubble oscillations. Several mechanisms have been proposed to relate dynamics sonoporation including shear and normal stress. The present work aims gain insight into role of size on thereby relevant mechanism(s) sonoporation. To this end, we measured efficiency while varying using monodisperse suspensions. experiments were performed in vitro cell monolayers a single ultrasound pulse with fixed...
Abstract Ultrasound-driven microbubbles are attractive for a variety of applications in medicine, including real-time organ perfusion imaging and targeted molecular imaging. In ultrasound-mediated drug delivery, bubbles decorated with functional payload become convenient transport vehicles offer highly localized release. How to efficiently release these nanomedicines the target site remains unclear owing microscopic length scales nanoseconds timescales process. Here, we show theoretically...
Mistletoe lectin-1 (ML1) is a nature-derived macromolecular cytotoxin that potently induces apoptosis in target cells. Non-specific cytotoxicity to normal cells one of the major risks its clinical application, and we therefore propose encapsulate ML1 nanocarrier can specifically release cargo intratumorally, thus improving efficacy toxicity ratio cytotoxin. We investigated encapsulation ultrasound-sensitive liposomes (USL) studied by high-intensity focused ultrasound (HAccessedIFU). USL were...
Recently, super-resolution ultrasound imaging with localization microscopy (ULM) has received much attention. However, ULM relies on low concentrations of microbubbles in the blood vessels, ultimately resulting long acquisition times. Here, we present an alternative approach, based direct deconvolution single-channel radio-frequency (RF) signals a one-dimensional dilated convolutional neural network (CNN). This work focuses low-frequency (1.7 MHz) for deep (10 cm) dense cloud monodisperse...
The understanding of the shrinkage dynamics plasmonic bubbles formed around metallic nanoparticles immersed in liquid and irradiated by a resonant light source is crucial for usage these numerous applications. In this paper, we experimentally show theoretically explain that bubble during its undergoes two different phases: first, rapid partial governed vapor condensation and, second, slow diffusion-controlled dissolution. history formation plays an important role first phase as it determines...
Monodisperse lipid-coated microbubbles are a promising route to unlock the full potential of ultrasound contrast agents for medical diagnosis and therapy. Here, we present stand-alone lab-on-a-chip instrument that allows be formed with high monodispersity at production rates. Key maintaining long-term stable, controlled, safe operation microfluidic device control over output size distribution is an optical transmission based measurement technique provides real-time information on rate bubble...
Ultrafast plane-wave ultrasound imaging is a versatile tool which has become increasingly relevant for blood flow using speckle tracking, but suffers from low signal-to-noise ratio (SNR). Cascaded dual-polarity waves (CDW) can improve the SNR by transmitting pulse trains, are subsequently decoded to recover resolution. However, current decoding method (in time domain) requires set of two acquisitions, introduces motion artifacts that result in incorrect tracking at high velocities. Here, we...