A5100738614- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Chemical Synthesis and Analysis
- Osteoarthritis Treatment and Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Cancer Research and Treatments
- Advanced Drug Delivery Systems
- Immune cells in cancer
- Immune Response and Inflammation
- HIV Research and Treatment
- Antimicrobial Peptides and Activities
- Luminescence Properties of Advanced Materials
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Microbial Natural Products and Biosynthesis
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- bioluminescence and chemiluminescence research
Leiden University Medical Center
2016-2025
Leiden University
2019-2023
Oncode Institute
2022
University of Havana
2021
Novem (Netherlands)
2021
Percuros (Netherlands)
2019
Radboud University Nijmegen
2009-2017
Radboud University Medical Center
2009-2017
Radboud Institute for Molecular Life Sciences
2012-2017
Institute for Research in Biomedicine
2006-2013
CM (ChemMatrix) resin is a new, totally poly(ethylene glycol) (PEG)-based resin, made exclusively from primary ether bonds and, therefore, highly chemically stable. It exhibits good loading and user-friendly because of its free-flowing form upon drying. performs excellently for the preparation hydrophobic, structured, poly-Arg peptides, as compared to polystyrene (PS) resins. In most striking example, stepwise solid-phase assembly complex β-amyloid (1−42) peptide resulted in crude material...
The efficiency of antigen ( A g) processing by dendritic cells DC s) is vital for the strength ensuing T ‐cell responses. Previously, we and others have shown that in comparison to protein vaccines, vaccination with synthetic long peptides SLP has more promising (pre‐)clinical results. Here, studied unknown mechanisms underlying observed vaccine efficacy s. We report an vitro analysis s MHC class I II presentation murine human monocyte‐derived Compared protein, were rapidly much efficiently...
Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of organic counterparts —photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results complex multilayer doping patterns and imperfectness switching UV–blue region. In this work, we have adopted new strategy construct Nd3+ free...
Plasmacytoid dendritic cells (pDCs) play a crucial role in initiating immune responses by secreting large amounts of type I IFNs. Currently, the for human pDCs as professional APCs cross-presentation exogenous Ags is being re-evaluated. Human are equipped with broad repertoire Ag uptake receptors and an efficient Ag-processing machinery. In this study, we set out to investigate which receptor can best be deployed deliver (cross-)presentation. We show that targeting nanoparticles via C-type...
The efficacy of immunotherapy against advanced cancer may be improved by combination strategies. Photodynamic therapy (PDT) is a local tumor ablation method based on localized activation photosensitizer, leading to oxygen radical-induced cell death. PDT can enhance antitumor immune responses release antigen and danger signals, supporting protocols with immunotherapy.We investigated the systemic effects after treatment established tumors. In two independent aggressive mouse models, TC-1 RMA,...
Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at defined sites, including tumors. Analyzing the of EVs target specific cells remains challenging, considering unspecific binding lipophilic tracers other proteins, limitations fluorescence deep tissue imaging and effect external labeling strategies tropism. In this work, we determined...
Intra-articular administration of anti-inflammatory drugs is a strategy that allows localized action on damaged articular cartilage and reduces the side effects associated with systemic drug administration. The objective this work to prepare injectable thermosensitive hydrogels for long-term application dexamethasone. were prepared by mixing chitosan (CS) Pluronic-F127 (PF) physically. In addition, tripolyphosphate (TPP) was used as crosslinking agent. Chitosan added mix increased gel time...
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a promising approach for anti-cancer immunotherapy by bridging innate and adaptive immunity. Recent evidence suggests that chemotherapy-induced DNA damage can directly induce dendritic cell (DC) maturation recruitment, which synergizes with STING activation to enhance anti-tumor effects. As an immunogenic death (ICD) inducer, oxaliplatin generates massive double-stranded (dsDNA) crosslinks, release...