A5064288208- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Biosensors and Analytical Detection
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Immunodeficiency and Autoimmune Disorders
- Brake Systems and Friction Analysis
- Immune responses and vaccinations
- Nanoparticle-Based Drug Delivery
- Listeria monocytogenes in Food Safety
- Orthopedic Infections and Treatments
- Surface Modification and Superhydrophobicity
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Viral Infections and Immunology Research
- CAR-T cell therapy research
Ghent University
2022-2024
Cancer Research Institute Ghent
2022-2024
Ghent University Hospital
2024
Abstract Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite high mortality rate and increasing antibiotic resistance no clinically approved vaccine against available. Attenuated strains offer protection are tested as antitumor vectors, but would benefit from better knowledge on immunodominant vector antigens. To identify novel antigens, we screen for peptides presented the surface of infected cell lines by mass spectrometry-based...
Although various types of mRNA-based vaccines have been explored, the optimal conditions for induction both humoral and cellular immunity remain rather unknown. In this study, mRNA nucleoside-modified in lipoplexes (LPXs) or lipid nanoparticles (LNPs) were evaluated after administration mice through different routes, assessing delivery, tolerability immunogenicity. addition, we investigated whether could benefit from inclusion adjuvant alpha-galactosylceramide (αGC), an invariant Natural...
Listeria monocytogenes is a foodborne intracellular bacterial model pathogen. Protective immunity against depends on an effective CD8
ABSTRACT Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite high mortality rate and increasing antibiotic resistance no clinically approved vaccine against available. Attenuated strains offer protection are tested as antitumor vectors, but would benefit from better knowledge on immunodominant vector antigens. To identify novel antigens, we screened for epitopes presented the surface of infected cell lines by mass spectrometry-based...