A5035116198- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Electrohydrodynamics and Fluid Dynamics
- Immune Cell Function and Interaction
- Photoacoustic and Ultrasonic Imaging
- Microfluidic and Bio-sensing Technologies
- Electrochemical Analysis and Applications
- Viral gastroenteritis research and epidemiology
- Spectroscopy and Quantum Chemical Studies
- Surface Modification and Superhydrophobicity
- Cellular Mechanics and Interactions
- Animal Virus Infections Studies
- Electrostatics and Colloid Interactions
- Optical Coherence Tomography Applications
- Micro and Nano Robotics
- Advanced Fluorescence Microscopy Techniques
Ghent University
2022-2024
Charles University
2023
Targeted drug delivery depends on the ability of nanocarriers to reach target site, which requires penetration different biological barriers. Penetration is usually low and slow because passive diffusion steric hindrance. Nanomotors (NMs) have been suggested as next generation in due their autonomous motion associated mixing hydrodynamics, especially when acting collectively a swarm. Here, we explore concept enzyme-powered NMs designed such that they can exert disruptive mechanical forces...
Abstract Biolistic intracellular delivery of functional macromolecules makes use dense microparticles which are ballistically fired onto cells with a pressurized gun. While it has been used to transfect plant cells, its application mammalian met limited success mainly due high toxicity. Here we present more refined nanotechnological approach biolistic light-triggered self-assembled nanobombs (NBs) that consist photothermal core particle surrounded by smaller nanoprojectiles. Upon irradiation...
Abstract To enable detailed studies of interactions between nanoparticles and their environment the correlations various nanoparticle properties, one must go beyond ensemble averages toward single‐particle measurements. However, current methodologies for single‐nanoparticle analysis charge size either lack flexibility to study dynamic processes on level or are highly specific require complex microfluidic devices. In addition, accurate measurements electrophoretic mobility (or zeta‐potential)...
Nanoparticle-based applications require increasingly sensitive screening tools, necessitating single-particle, multi-parameter analysis techniques in the native liquid environment. In this work, we present a laser-scanning camera using acousto-optic deflectors and single-photon counting module. By scanning highly focused laser beam (532 nm) across grid of pixels, by detecting associated emitted photons with high sensitivity, fluorescent nanoparticles 100 nm below can be imaged at frame rates...
The development of nanoparticle-based applications relies increasingly on our ability to characterize nanoparticles at the single-particle level and in their native liquid environment. In quantum dot applications, for example, a detailed understanding how spectral properties are related differences size, shape, composition electrical charge is crucial optimize fabrication process dots ultimately photonic or biomedical applications. Since deposition substrate may disturb spectroscopic...