A5049617197- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Hepatitis C virus research
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Liver Diseases and Immunity
- RNA Interference and Gene Delivery
- Electrohydrodynamics and Fluid Dynamics
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Receptor Mechanisms and Signaling
- Advanced biosensing and bioanalysis techniques
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- CRISPR and Genetic Engineering
- Wound Healing and Treatments
- Hepatitis B Virus Studies
- Tissue Engineering and Regenerative Medicine
- Statistical Methods in Clinical Trials
- Microfluidic and Bio-sensing Technologies
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Lipid metabolism and disorders
Vrije Universiteit Brussel
2019-2022
Institute for In Vitro Sciences
2021
Geneeskundige en Gezondheidsdienst
2019
Abstract Biolistic intracellular delivery of functional macromolecules makes use dense microparticles which are ballistically fired onto cells with a pressurized gun. While it has been used to transfect plant cells, its application mammalian met limited success mainly due high toxicity. Here we present more refined nanotechnological approach biolistic light-triggered self-assembled nanobombs (NBs) that consist photothermal core particle surrounded by smaller nanoprojectiles. Upon irradiation...
Background and aims: Non-alcoholic steatohepatitis (NASH) is a life-threatening stage of non-alcoholic fatty liver disease (NAFLD) for which no drugs have been approved. We previously shown that human-derived hepatic in vitro models can be used to mimic key cellular mechanisms involved the progression NASH. In present study, we first characterize transcriptome multiple NASH models. Subsequently, investigate how elafibranor, peroxisome proliferator-activated receptor (PPAR)-α/δ agonist has...
Human skin-derived precursors (SKP) represent a group of somatic stem/precursor cells that reside in dermal skin throughout life harbor clinical potential. SKP have high self-renewal capacity, the ability to differentiate into multiple cell types and low immunogenicity, rendering them key candidates for allogeneic cell-based, off-the-shelf therapy. However, potential application requires these retain their therapeutic properties under all circumstances and, particular, presence an...
Non-alcoholic steatohepatitis (NASH) is a severe chronic liver disease that affects 3 to 5 percent of the world population. It characterized by hepatic lipid accumulation and inflammation can progress towards fibrosis, cirrhosis hepatocellular carcinoma. Until today, no drug has been approved for treatment NASH. This delay relates complex pathogenesis NASH also lack appropriate predictive preclinical testing systems. Furthermore, human specificity pathology hampers fortiori clinical...
Neonatal liver-derived rat epithelial cells (rLEC) from biliary origin are liver progenitor that acquire a hepatocyte-like phenotype upon sequential exposure to hepatogenic growth factors and cytokines. Undifferentiated rLEC express several liver-enriched transcription factors, including the hepatocyte nuclear (HNF) 3β HNF6, but not hepatic master regulator HNF4α. In this study, we first investigated impact of ectopic expression HNF4α in on both mRNA microRNA (miR) level by means microarray...