A5010525418- Micro and Nano Robotics
- Pickering emulsions and particle stabilization
- Molecular Communication and Nanonetworks
- Photoreceptor and optogenetics research
- Characterization and Applications of Magnetic Nanoparticles
- Supramolecular Self-Assembly in Materials
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Genetic and Kidney Cyst Diseases
- Lipid Membrane Structure and Behavior
- Electrohydrodynamics and Fluid Dynamics
- Cellular Mechanics and Interactions
- Advanced Materials and Mechanics
- Microfluidic and Bio-sensing Technologies
- Drug Transport and Resistance Mechanisms
- Spaceflight effects on biology
- Algal biology and biofuel production
- Enzyme Production and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Polydiacetylene-based materials and applications
- Electrochemical sensors and biosensors
- Iron oxide chemistry and applications
- Protein Interaction Studies and Fluorescence Analysis
- Enzyme Catalysis and Immobilization
Institute for Bioengineering of Catalonia
2016-2024
Barcelona Institute for Science and Technology
2017-2024
Sorbonne University Abu Dhabi
2023
Sorbonne Université
2023
PHENIX laboratory
2023
Centre National de la Recherche Scientifique
2023
Max Planck Institute for Intelligent Systems
2016-2017
Stuttgart Observatory
2017
Institute of Science and Technology
2017
Shanghai Institute for Science of Science
2017
Abstract The use of enzyme catalysis to power micro‐ and nanomotors exploiting biocompatible fuels has opened new ventures for biomedical applications such as the active transport delivery specific drugs site interest. Here, urease‐powered (nanobots) doxorubicin (Dox) anticancer drug loading, release, efficient cells are presented. These mesoporous silica‐based core–shell nanobots able self‐propel in ionic media, confirmed by optical tracking dynamic light scattering analysis. A four‐fold...
Cancer is one of the main causes death around world, lacking efficient clinical treatments that generally present severe side effects. In recent years, various nanosystems have been explored to specifically target tumor tissues, enhancing efficacy cancer treatment and minimizing particular, bladder ninth most common worldwide presents a high survival rate but serious recurrence levels, demanding an improvement in existent therapies. Here, we urease-powered nanomotors based on mesoporous...
Enzyme-powered nanomotors are an exciting technology for biomedical applications due to their ability navigate within biological environments using endogenous fuels. However, limited studies into collective behavior and demonstrations of tracking enzyme in vivo have hindered progress toward clinical translation. Here, we report the swarming urease-powered its positron emission tomography (PET), both vitro vivo. For that, mesoporous silica nanoparticles containing urease enzymes gold were...
The introduction of stimuli-responsive cargo release capabilities on self-propelled micro- and nanomotors holds enormous potential in a number applications the biomedical field. Herein, we report preparation mesoporous silica nanoparticles gated with pH-responsive supramolecular nanovalves equipped urease enzymes which act as chemical engines to power nanomotors. are loaded different molecules ([Ru(bpy)3]Cl2 (bpy = 2,2′-bipyridine) or doxorubicin), grafted benzimidazole groups outer surface,...
Abstract Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs passive nanoparticles. However, translational treating bladder are underexplored. Here, we tested radiolabelled mesoporous silica-based...
The motion of self-propelled tubular micro- and nanojets has so far been achieved by bubble propulsion, e.g., O2 bubbles formed catalytic decomposition H2O2, which renders future biomedical applications inviable. An alternative self-propulsion mechanism for engines on the nanometer scale is still missing. Here, we report fabrication characterization bubble-free propelled (as small as 220 nm diameter), powered an enzyme-triggered biocatalytic reaction using urea fuel. We studied translational...
Abstract We report lipase‐based nanomotors that are capable of enhanced Brownian motion over long periods time in triglyceride solution and degrading droplets mimic “blood lipids”. achieved about 40 min diffusion lipase‐modified mesoporous silica nanoparticles (MSNPs) through a biocatalytic reaction between lipase its corresponding water‐soluble oil substrate (triacetin) as fuel, which resulted an coefficient (ca. 50 % increase) at low triacetin concentration (<10 m ). Lipase not only...
The low efficacy of current conventional treatments for bacterial infections increases mortality rates worldwide. To alleviate this global health problem, we propose drug-free enzyme-based nanomotors the treatment urinary-tract infections. We develop consisting mesoporous silica nanoparticles (MSNPs) that were functionalized with either urease (U-MSNPs), lysozyme (L-MSNPs), or and (M-MSNPs), use them against nonpathogenic planktonic Escherichia coli. U-MSNPs exhibited highest bactericidal...
Targeted drug delivery depends on the ability of nanocarriers to reach target site, which requires penetration different biological barriers. Penetration is usually low and slow because passive diffusion steric hindrance. Nanomotors (NMs) have been suggested as next generation in due their autonomous motion associated mixing hydrodynamics, especially when acting collectively a swarm. Here, we explore concept enzyme-powered NMs designed such that they can exert disruptive mechanical forces...
Abstract Over the past decades, development of nanoparticles (NPs) to increase efficiency clinical treatments has been subject intense research. Yet, most NPs have reported possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in joints mainly composed hyaluronic acid (HA). These viscous media pose a challenge for many applications nanomedicine, passive tend become trapped complex networks, which reduces ability reach target...
Abstract Developing self‐powered nanomotors made of biocompatible and functional components is paramount importance in future biomedical applications. Herein, the features LipoBots (LBs) composed a liposomal carrier containing urease enzymes for propulsion, including their protective properties against acidic conditions on‐demand triggered activation, are reported. Given nature liposomes, can be either encapsulated or coated on surface vesicles. The influence location motion dynamics first...
In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inflammatory drug naproxen and C-terminal dehydroamino acids, dehydrophenylalanine (ΔPhe), dehydroaminobutyric acid (ΔAbu), dehydroalanine (ΔAla) as efficacious protease resistant hydrogelators. Optimized conditions for gel formation are reported. Transmission electron microscopy experiments revealed that hydrogels consist of networks micro/nanosized fibers formed by peptide self-assembly....
Facile strategy for the fabrication of mesoporous silica micro-jets (MSMJs) as novel structure tubular micromotors which can serve a common platform able to carry out different tasks <italic>via</italic> surface functionalities.
Abstract We report lipase‐based nanomotors that are capable of enhanced Brownian motion over long periods time in triglyceride solution and degrading droplets mimic “blood lipids”. achieved about 40 min diffusion lipase‐modified mesoporous silica nanoparticles (MSNPs) through a biocatalytic reaction between lipase its corresponding water‐soluble oil substrate (triacetin) as fuel, which resulted an coefficient (ca. 50 % increase) at low triacetin concentration (<10 m ). Lipase not only...
Abstract Self‐propelled particles and, in particular, those based on mesoporous silica, have raised considerable interest due to their potential applications the environmental and biomedical fields thanks biocompatibility, tunable surface chemistry large porosity. Although spherical been widely used fabricate nano‐ micromotors, not much attention has paid other geometries, such as nanorods. Here, we report fabrication of self‐propelled silica nanorods (MSNRs) that move by catalytic...
Magnetic nanoparticles have been extensively explored as theranostic agents both in academic and clinical settings. Their self-assembly into nanohybrids using block copolymers can lead to new nanostructures with high functionalities performances. Herein, we demonstrate a high-throughput scalable method elaborate magnetic micelles by the assembly of iron oxide magnetite nanoflowers, an efficient nanoheater, copolymer Poly(styrene)-block-poly(acrylic acid) via microfluidic-assisted...
Magnetic nanoparticles have been extensively explored as theranostic agents both in academic and clinical settings. Their self-assembly into nanohybrids using block copolymers can lead to new nanostructures with high functionalities performances. Herein, we demonstrate a high-throughput scalable method elaborate magnetic micelles by the assembly of iron oxide magnetite nanoflowers, an efficient nanoheaters, copolymer Poly(styrene)−block−poly(acrylic acid) via microfluidic-assisted...
Abstract Enzyme powered nanomotors hold great potential for biomedical applications, as they show improved diffusion and navigation within biological environments using endogenous fuels. Yet, understanding their collective behavior tracking them in vivo is paramount clinical translation. Here, we report on the vitro study of swarms self-propelled enzyme-nanomotors effect distribution bladder. For that purpose, mesoporous silica were functionalized with urease enzymes gold nanoparticles. Two...
Abstract Bladder cancer (BC) is among the most common cancers worldwide. Current treatment methods involving intravesical drug administration present good survival rates but low therapeutic efficacy. Self-propelled nanoparticles (nanobots) could overcome these limitations through their enhanced diffusion and mixing capabilities in urine compared to conventional drugs or passive nanoparticles. Here, we radiolabeled mesoporous silica-based urease-powered nanobots for imaging purposes tested...