A5079181602- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Neuroblastoma Research and Treatments
- Voice and Speech Disorders
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Dysphagia Assessment and Management
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Breast Cancer Treatment Studies
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Sarcoma Diagnosis and Treatment
Ente Ospedaliero Ospedali Galliera
2016-2025
ORCID
2024
IRCCS Humanitas Research Hospital
2021-2023
Universitätsklinikum Tübingen
2017-2023
Ospedale Policlinico San Martino
2014-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2022
University of Tübingen
2017-2022
Azienda Sanitaria Unità Locale di Reggio Emilia
2022
University of Bologna
2022
TH Bingen University of Applied Sciences
2022
Several studies have highlighted the role of vascular (18)F-NaF uptake as a marker ongoing calcium deposition. However, accumulation is often inconsistent with localization arterial plaque. Calcification activity and thus might prevail in earlier plaque stages. To test this hypothesis, we evaluated 3 different densities, using density calcification progression. We also tested whether attenuation-weighted image reconstruction affects stages.Sixty-four oncologic patients (14 men 50 women; mean...
The present translational study aimed to verify whether serial 18F-FDG PET/CT predicts doxorubicin cardiotoxicity. Methods: Fifteen athymic mice were treated intravenously with saline (n = 5) or 5 7.5 mg of per kilogram each) and underwent dynamic small-animal PET beforehand afterward estimate left ventricular (LV) metabolic rate glucose (MRGlu). Thereafter, we retrospectively identified 69 patients who had been successfully a regimen doxorubicin, bleomycin, vinblastine, dacarbazine for...
In the course of metformin treatment, staging abdominal cancer lesions with (18)F-FDG PET images is often hindered by presence a high bowel radioactivity. The present study aimed to verify mechanism underlying this phenomenon.Fifty-three mice were submitted dynamic acquisitions kinetics under fasting conditions. Three small-animal scans obtained over 4-mo period. animals subdivided into 4 groups according following administration protocol: group 1, untreated (n = 15); 2, exposed treatment...
Transoral laser microsurgery (TLM) represents one of the most effective treatment strategies for Tis-T2 glottic squamous cell carcinomas (SCC). The prognostic influence close/positive margins is still debated, and role narrow band imaging (NBI) in their intraoperative definition to be validated on large cohort patients. This study analyzed margin status recurrence-free survival (RFS) disease-specific (DSS).We retrospectively studied 507 cases pTis-T1b (Group A) 127 pT2 B) SCC. We identified...
Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite very successful and widespread use of checkpoint inhibitors in clinic, majority cancer patients do not benefit from this type treatment. In translational study, we investigated whether noninvasive vivo positron emission tomography (PET) imaging using 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) is capable detecting immunotherapy-associated metabolic changes...
Standard imaging cannot assess the pathology details of intrahepatic cholangiocarcinoma (ICC). We investigated whether CT-based radiomics may improve prediction tumor characteristics. All consecutive patients undergoing liver resection for ICC (2009-2019) in six high-volume centers were evaluated inclusion. On preoperative CT, we segmented (Tumor-VOI, i.e., volume-of-interest) and a 5-mm parenchyma rim around (Margin-VOI). considered two types data: grading (G) microvascular invasion (MVI)....
Advanced imaging and analysis improve prediction of pathology data outcomes in several tumors, with entropy-based measures being among the most promising biomarkers. However, entropy is often perceived as statistical lacking clinical significance. We aimed to generate a voxel-by-voxel visual map local tumor entropy, thus allowing (1) make explainable accessible clinicians; (2) disclose quantitively characterize any intra-tumoral heterogeneity; (3) evaluate associations between data. analyzed...
Peptide receptor radionuclide therapy (PRRT) is an effective and well-tolerated treatment option for patients with neuroendocrine tumors (NETs) that prolongs progression-free survival (PFS). However, the limited overall (OS) rates in prospective phase III study (NETTER1) highlighted need to identify patient-specific long-term prognostic markers avoid unnecessary side effects enable better stratification. Therefore, we retrospectively analyzed risk factors NET treated PRRT.A total of 62 (G1:...
Molecular imaging of muscle-invasive bladder cancer (MBC) is restricted to its locoregional and distant metastases, since most radiopharmaceuticals have a urinary excretion that limits the visualization primary tumor.
Background: The role of radioiodine (RAI) therapy for differentiated thyroid cancers (DTCs) is still a matter debate. Low-dose RAI (LDRAI) possible treatment patients at low–intermediate risk recurrence. aim this study was to evaluate the occurrence post-RAI clinical and biochemical side effects with respect its dosage. Methods: We retrospectively examined 142 who had been administered DTCs carried out least 12-month follow-up. incidence adverse events (CAEs: xerophthalmia, xerostomia,...
Objective Idiopathic subglottic stenosis predominantly affects fertile and perimenopausal women. Estrogens and/or progesterone have been proposed as mediators of its pathogenesis by stimulating collagen deposition within the upper airway. We evaluated presence expression estrogen‐alpha (ER‐α), estrogen‐beta (ER‐β), receptors (PR) in idiopathic stenotic patients. Study Design A retrospective analysis on 42 surgical specimens from female patients (mean age, 52.4; age range, 31–79) 28 gender‐...