A5017477138- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Thyroid and Parathyroid Surgery
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Head and Neck Anomalies
- Prostate Cancer Treatment and Research
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Metabolism, Diabetes, and Cancer
- Radiation Dose and Imaging
- BRCA gene mutations in cancer
- Bone health and treatments
- Hematopoietic Stem Cell Transplantation
- Vitamin D Research Studies
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Hematological disorders and diagnostics
- Pancreatic function and diabetes
- Lung Cancer Treatments and Mutations
Ente Ospedaliero Ospedali Galliera
2016-2025
Ente Ospedaliero Cantonale
2021
Repubblica e Cantone Ticino
2021
Istituto Giannina Gaslini
2018
Ospedale Policlinico San Martino
2014-2016
University of Genoa
2013-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2015
Hull York Medical School
2014
Department of Medical Sciences
2013
National Cancer Research Institute
2013
Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In present study, we demonstrate metformin directly inhibits enzymatic function hexokinase (HK) I II cell line triple-negative breast cancer (MDA-MB-231). The inhibition is selective for these isoforms, as documented by experiments with purified HK well lysates. Measurements (18)F-fluoro-deoxyglycose uptake document it dose- time-dependent powerful...
Abstract Cancer metabolism is characterized by an accelerated glycolytic rate facing reduced activity of oxidative phosphorylation. This “Warburg effect” represents a standard to diagnose and monitor tumor aggressiveness with 18 F-fluorodeoxyglucose whose uptake currently regarded as accurate index total glucose consumption. Studying cancer metabolic response respiratory chain inhibition metformin, we repeatedly observed reduction tracer marked increase in puzzling discordance brought us...
We aimed to investigate the accuracy of FDG-PET detect Alzheimer's disease (AD) brain glucose hypometabolic pattern in 142 patients with amnestic mild cognitive impairment (aMCI) and 109 healthy controls. aMCI were followed for at lea
Our objective was to evaluate the biodistribution, kinetics, and radiation dosimetry of <sup>64</sup>CuCl<sub>2</sub> in humans assess ability PET/CT detect prostate cancer (PCa) recurrence patients with biochemical relapse. <b>Methods:</b> We prospectively evaluated 50 PCa relapse after surgery or external-beam therapy. All underwent PET/CT, <sup>18</sup>F-choline multiparametric MRI within 15 d each other. Experienced readers interpreted images, detection rate (DR) imaging modality...
Abstract Emerging evidence demonstrates that targeting energy metabolism is a promising strategy to fight cancer. Here we show combining metformin and short-term starvation markedly impairs growth of colon breast The impairment in glycolytic flux caused by enhanced through its interference with hexokinase II activity, as documented measurement 18F-fluorodeoxyglycose uptake. Oxidative phosphorylation additively compromised combined treatment: virtually abolishes Complex I function; determines...
Our purpose was to evaluate the diagnostic role of <sup>18</sup>F-3,4-dihydroxyphenylalanine (DOPA) PET/CT at time staging in children with neuroblastoma and investigate its ability assess treatment response. We also investigated prognostic value <sup>18</sup>F-DOPA same points. <b>Methods:</b> enrolled onset. Before after induction chemotherapy, all patients underwent <sup>123</sup>I-metaiodobenzylguanidine (MIBG) scanning plus SPECT/CT. results were compared those <sup>123</sup>I-MIBG...
99mTc-MIBI (MIBI) imaging is able to exclude malignancy of hypofunctioning thyroid nodules (TNs) with high probability but false positive results are frequent due low specificity. Therefore, pre-test selection appropriate TNs crucial. For image evaluation visual and semiquantitative methods (Washout index, WOInd) used. Aim this study was evaluate the diagnostic performance MIBI in indeterminate fine-needle aspiration cytology a multicentric European setting. Patients TNs, EU-TIRADS 4 or 5,...
To investigate the value of presurgical
Molecular imaging of muscle-invasive bladder cancer (MBC) is restricted to its locoregional and distant metastases, since most radiopharmaceuticals have a urinary excretion that limits the visualization primary tumor.
The aim of the present study is to evaluate kinetics and dosimetry 64CuCl2 in human prostate cancer (PCa) lesions. We prospectively evaluated 50 PCa patients with biochemical relapse after surgery or external beam radiation therapy. All underwent 64CuCl2-PET/CT detect recurrence/metastases. Volumes interest were manually drawn for each avid lesion a diameter > 1 cm on mpMRI patient. Time-activity curves all lesions obtained. effective biological half-life standard uptake values (SUVs)...