A5009880744- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Reconstructive Surgery and Microvascular Techniques
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Reconstructive Facial Surgery Techniques
- Oral health in cancer treatment
- Olfactory and Sensory Function Studies
- Airway Management and Intubation Techniques
- Thyroid Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Sarcoma Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
University of Brescia
2016-2025
Humanitas University
2023-2025
Stanford University
2025
IRCCS Humanitas Research Hospital
2023-2025
Fondazione Humanitas per la Ricerca
2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2017-2023
State of Illinois
2020
Fondazione IRCCS Istituto Nazionale dei Tumori
2018-2019
University of Milan
2016-2019
Brescia University
2019
Abstract Purpose This study aimed to evaluate the utility of large language model (LLM) artificial intelligence tools, Chat Generative Pre-Trained Transformer (ChatGPT) versions 3.5 and 4, in managing complex otolaryngological clinical scenarios, specifically for multidisciplinary management odontogenic sinusitis (ODS). Methods A prospective, structured specialist evaluation was conducted using five ad hoc designed ODS-related scenarios. LLM responses these scenarios were critically reviewed...
Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. However, their prevalence in different patient populations still needs clarified.A cross-sectional study was performed from March 27 April 1, 2020, Northern Italy. Physicians administered survey-based questionnaire SARS-CoV-2-positive patients with the aim assessing symptoms, focusing on OD GD. Two groups were studied: group A,...
Objective To prospectively assess the rate and timing of recovery olfactory (OD) gustatory (GD) dysfunction in patients affected by COVID‐19. Study Design Cohort study. Setting Population‐based evaluation a COVID‐19 high‐prevalence region. Subjects Methods We analyzed clinical course OD GD cohort home‐quarantined SARS‐CoV‐2–positive from Northern Italy. Physicians administered survey‐based questionnaire at recruitment (T0). During follow‐up, responded to online dedicated surveys modulated...
Objectives/Hypothesis To identify a clinical predictor score for difficult laryngeal exposure (DLE) during operative microlaryngoscopy. Study Design Prospective cohort study in two academic institutions. Methods We evaluated 319 patients before microlaryngoscopy benign and malignant glottic diseases by standardized preoperative assessment protocol (Laryngoscore) that included 11 parameters: interincisors gap (IIG), thyro‐mental distance, upper jaw dental status, trismus, mandibular...
Abstract Head and neck cancer (HNC) patients suffer from a range of health‐related quality life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, survivors completed the European Organization for Research Treatment Cancer (EORTC) core questionnaire (EORTC‐QLQ‐C30) its module (EORTC‐QLQ‐H&N35). Meaningful differences...
Objective To investigate the potential of deep learning for automatically delineating (segmenting) laryngeal cancer superficial extent on endoscopic images and videos. Methods A retrospective study was conducted extracting annotating white light (WL) Narrow‐Band Imaging (NBI) frames to train a segmentation model ( SegMENT‐Plus ). Two external datasets were used validation. The model's performances compared with those two otolaryngology residents . In addition, tested real intraoperative...
To describe patient positioning maneuvers that optimize visualization of the oropharynx during flexible endoscopy. An institutional database videos obtained from 2021 to 2023 endoscopy patients with oropharyngeal carcinoma (OPC) was reviewed. Patients seen outside specialty head and neck clinic, those tonsillar primary tumors, only fiberoptic swallowing evaluations were excluded. A total 10 then independently analyzed by 2 reviewers assess effects 4 on tumor visualization: chin elevation,...
Survival rates of oral squamous cell carcinoma (OSCC) remained substantially unchanged over the last decades; thus, additional prognostic tools are strongly needed.Salivary miRNAs have emerged as excellent non-invasive cancer biomarker candidates, but their association with OSCC prognosis has not been investigated yet.In this study, we analyzed global salivary miRNA expression in patients and healthy controls, aim to define its diagnostic potential.Methods: Saliva was collected from newly...
Fully convoluted neural networks (FCNN) applied to video-analysis are of particular interest in the field head and neck oncology, given that endoscopic examination is a crucial step diagnosis, staging, follow-up patients affected by upper aero-digestive tract cancers. The aim this study was test FCNN-based methods for semantic segmentation squamous cell carcinoma (SCC) oral cavity (OC) oropharynx (OP).Two datasets were retrieved from institutional registry tertiary academic hospital...
Objective: This study aimed to evaluate complications and success rates of tracheal resection anastomosis (TRA) cricotracheal (CTRA) in patients treated 2 academic institutions. Methods: Retrospective charts review 137 submitted TRA/CTRA. Fifty (36.5%) had neoplastic (group A) 87 (63.5%) benign B) stenoses. Using univariate analysis, age, medical comorbidities, previous radiotherapy, type TRA/CTRA, association with neck dissection thyroidectomy, length resected airway, preoperative...
Transoral laser microsurgery (TLM) represents one of the most effective treatment strategies for Tis-T2 glottic squamous cell carcinomas (SCC). The prognostic influence close/positive margins is still debated, and role narrow band imaging (NBI) in their intraoperative definition to be validated on large cohort patients. This study analyzed margin status recurrence-free survival (RFS) disease-specific (DSS).We retrospectively studied 507 cases pTis-T1b (Group A) 127 pT2 B) SCC. We identified...
Abstract Background Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. “Compartmental” hemiglossopelvectomy (CHGP) was developed to improve loco‐regional control by “en bloc” removal tumor its pathways spread. Methods We conducted retrospective observational study on 45 CHGPs performed at single institution for OTFMSCC DOI CT/MR. Group A ( n = 35) included naïve patients,...
The restart of routine in‐ and outpatient activity in the COVID‐19 postepidemic peak needs to be carefully planned light specific patterns viral diffusion. We evaluated SARS‐CoV‐2 serology entire personnel a COVID‐19‐free otolaryngology department highly affected area. aim was determine prevalence positivity among staff clarify impact different risk factors for infection. unit tested serology. Symptomatic members were with nasal/pharyngeal swabs. All answered survey focused on number...
Objectives To investigate the prognostic significance of preoperative neutrophil to lymphocyte ratio (NLR) and impact different clinical-pathologic factors in a series primary oral squamous cell carcinomas (OSCC). Materials Methods All naive OSCCs treated with upfront surgery between 2000 2014 were retrospectively reviewed. Patients distant metastasis, synchronous head neck cancer, immunological disorders, or who had received previous chemotherapy and/or radiation area excluded. The main...
Narrow Band Imaging (NBI) is an endoscopic visualization technique useful for upper aero-digestive tract (UADT) cancer detection and margins evaluation. However, NBI analysis strongly operator-dependent requires high expertise, thus limiting its wider implementation. Recently, artificial intelligence (AI) has demonstrated potential applications in UADT videoendoscopy. Among AI methods, deep learning algorithms, especially convolutional neural networks (CNNs), are particularly suitable...
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the quality life in this population, 1114 HNCS were asked to state their two most serious effects. A clinician recorded responses during face-to-face appointments. list 15 example was provided, but free text field also available. total 1033 responded question. frequent 'dry mouth' (DM) (n = 476; 46%), 'difficulty swallowing/eating' (DSE) 408; 40%),...
Laryngeal exposure is one of the most limiting factors in transoral laser microsurgery (TLM) for glottic cancer. We evaluated correlation between degree laryngeal exposure, as assessed by an easy previously described scoring tool (Laryngoscore), and histopathologic surgical margin status after TLM.Prospective evaluation 147 patients affected Tis-T2 cancer treated TLM with curative intent January 2012 April 2016.All were preoperatively classified having good (group A including Laryngoscore...