A5015167643- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Oral microbiology and periodontitis research
- Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Vehicle Routing Optimization Methods
- Epigenetics and DNA Methylation
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Tracheal and airway disorders
- Foreign Body Medical Cases
- Intestinal and Peritoneal Adhesions
- Otolaryngology and Infectious Diseases
- Digital Imaging in Medicine
- Parathyroid Disorders and Treatments
- Leprosy Research and Treatment
- Histiocytic Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Optimization and Packing Problems
- Cancer Cells and Metastasis
Hospital de Câncer de Barretos
2015-2024
Centro Universitário da Fundação Educacional de Barretos
2023
Hospital São Paulo
2023
Faculdade Evangélica do Paraná
2012-2016
Universidade de São Paulo
2016
Hospital Universitário Evangélico de Curitiba
2008
Medico
2000
Abstract Head and neck cancer (HNC) patients suffer from a range of health‐related quality life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, survivors completed the European Organization for Research Treatment Cancer (EORTC) core questionnaire (EORTC‐QLQ‐C30) its module (EORTC‐QLQ‐H&N35). Meaningful differences...
ABSTRACT Background Body mass index (BMI) has been associated variably with head and neck cancer outcomes. We evaluated the association between BMI at either diagnosis or early adulthood Methods Patients invasive squamous cell Princess Margaret Cancer Centre in Toronto, Canada, were surveyed on tobacco alcohol exposure, performance status, comorbidities, diagnosis. A subset also had data collected for adulthood. Results With a median follow‐up of 2.5 years, 1279 analyzed patients, being...
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the quality life in this population, 1114 HNCS were asked to state their two most serious effects. A clinician recorded responses during face-to-face appointments. list 15 example was provided, but free text field also available. total 1033 responded question. frequent 'dry mouth' (DM) (n = 476; 46%), 'difficulty swallowing/eating' (DSE) 408; 40%),...
Oral squamous cell carcinoma (OSCC) is an extremely aggressive disease associated with a poor prognosis. Previous studies have established that cancer stem cells (CSCs) actively participate in OSCC development, progression and resistance to conventional treatments. Furthermore, CSCs frequently exhibit deregulated expression of normal signalling pathways, thereby acquiring their distinctive abilities, which self-renewal example. In this study, we examined the effects GLI3 knockdown OSCC, as...
Background: Thyroid nodules can be identified in up to 68% of the population. Fine-needle aspiration (FNA) cytopathology classifies 20%-30% as indeterminate, and these are often referred for surgery due risk malignancy. However, histological postsurgical reports indicate that 84% cases benign, highlighting a high rate unnecessary surgeries. We sought develop validate microRNA (miRNA)-based thyroid molecular classifier precision endocrinology (mir-THYpe) with both sensitivity specificity,...
The evolution of radiotherapy over recent decades has reintroduced the hypofractionation for many tumor sites with similar outcomes to those conventional fractionated radiotherapy. use in locally advanced head and neck cancer (LAHNC) been already used, however, its restricted only a few countries. aim this trial was evaluate safety feasibility moderate hypofractionated (HYP-RT) concomitant cisplatin (CDDP). This single-arm designed HYP-RT CDDP LAHNC. Stage III IV patients withnonmetastatic...
Purpose: The aim of this study was to validate the new European Organisation for Research and Treatment Cancer Quality Life Thyroid Module (EORTC QLQ-THY34). Methods: We enrolled 437 thyroid cancer patients from 17 countries. One group (n = 303), undergoing treatment or best supportive care, completed questionnaires at three time points (before therapy [t1], 6 weeks later [t2], months after t2 [t3]). A second (survivors ≥2 years diagnosis, n 134) it a random baseline point 1 week later....
Background Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features. Material methods We conducted across-sectional on patients OPSCC treated at a single institution from 2014 2019. Epidemiological clinical-pathological data were collected medical records questionnaire applied determine alcohol consumption, smoking, sexual behavior. HPV...
Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to susceptibility Human Papillomavirus (HPV). aim of our study was assess the whole genetic ancestry in status OPSCC patients. Methods: We conducted a cross-sectional on patients with admitted Barretos Cancer Hospital, Brazil from 2014 2019. Of these, DNA extraction performed 40 and assessed using specific panel 46 informative...
Health economic appraisals often rely on the assessment of health utilities using preference-based measures (PBM). The cancer-specific PBM, European Organisation for Research and Treatment Cancer Quality Life Utility - Core 10 Dimensions (EORTC QLU-C10D), was developed recently, now needs to be validated in various clinical populations.
In this multi-ancestry genome-wide association study (GWAS) and fine mapping of head neck squamous cell carcinoma (HNSCC) subsites, we analysed 19,073 cases 38,857 controls identified 29 independent novel loci. We provide robust evidence that a 3' UTR variant in
Objective To identify any association between type 2 diabetes mellitus (T2DM) and survival outcomes for mucosal squamous cell carcinoma of the head neck. An has been demonstrated T2DM cancer at numerous sites, but data neck are limited. Improving our understanding impact that on is relevant making treatment decisions counseling patients regarding prognosis. Study Design Retrospective cohort study. Setting Academic tertiary referral center. Subjects Methods By accessing retrospectively from...
OBJETIVO: Verificar a eficácia e complicações da correção cirúrgica de hérnias incisionais por enxerto tela polipropileno envolta tecido fibroso, em comparação com polipropileno. MÉTODOS: Foram utilizados 25 ratos Wistar machos fêmeas, distribuídos dois grupos: controle experimento. O grupo experimento, 15 animais, foi submetido ao implante seu subcutâneo. Após 21 dias, removida serviu para uma hérnia abdominal induzida. Os animais foram eutanasiados após dias submetidos à análise...
Abstract Background: Tobacco or human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) represent different clinical and epidemiologic entities. This study investigated the prevalence of HPV-positive HPV-negative OPSCC in a reference cancer hospital Brazil its association with demographic data, as well impact on overall survival. Methods: HPV infection was determined by p16-IHC pre-treatment formalin-fixed paraffin-embedded samples from all patients diagnosed at...
Introduction The prevalence of oropharyngeal squamous cell carcinoma (OSCC) related to Human Papillomavirus (HPV) is rising in the whole world. Objective To access and temporal trend HPV infection cancer by analyzing expression p16 protein. Methods We conducted a transversal study Brazilian reference oncology center. sample consisted 254 patients with OSCC. analyzed period was from 2013 2017. All underwent immunohistochemistry analysis. Results overall HPV-related OSCC 31.9%. During period,...
A osteomalácia oncogênica hipofosfatêmica (OOH) é uma síndrome paraneoplásica induzida por tumor, de tecidos mole ou ósseo. Apresenta-se com dor e fraturas, acompanhada hipofosfatemia, hiperfosfatúria concentrações plasmáticas 1,25(OH)2D3 inapropriadamente normais/diminuídas. Após a remoção do completa resolução das anormalidades clínicas bioquímicas sua maior característica. Uma mulher 44 anos idade descrita no caso dificuldade para caminhar causa dores nos membros inferiores, fraqueza...
Counting the sponges is an important step in surgical procedures. A miscount may impact patient's health, and it also has legal implications for surgeon. This experimental study evaluating radio-frequency technology used perioperative period to identify left peritoneal cavity of swine.Radio-frequency labeled-disc identification tags were sewn into 40 towels. Twenty labels had ability emit waves, 20 inert identification. adult pigs that underwent laparotomy randomly received two scanned by a...
Background: The development of didactic means to create opportunities permit complete and repetitive viewing surgical procedures is great importance nowadays due the increasing difficulty doing in vivo training. Thus, audiovisual resources favor maximization living used education, minimize problems arising only with verbalism. Aim: To evaluate use digital video as a pedagogical strategy technique teaching medical education. Methods: Cross-sectional study 48 students third year medicine, when...
Abstract Evaluate the biological action of valproic acid in acetylation histones and methylation tumor suppressor genes via oral rinse patients with a previous history head neck squamous cell carcinoma (HNSCC). Forty-two active or former smokers were included this randomized, double-blind, placebo-controlled trial. Oral samples collected prior to treatment placebo after 90 days treatment. The status five histone evaluated by pyrosequencing ELISA techniques, respectively. Differences between...
Objective: To evaluate the possible association between periodontal disease and breast cancer in women. Methods: This is a systematic literature review combined with meta-analysis. Five databases were searched, relevant published studies retrieved selected. The articles evaluated subsequently synthesized using PRISMA methodology. Odds Ratios (OR) 95% confidence intervals (CI) calculated to PD risk of cancer. selected for meta-analysis separated into two groups, as follows: (a) that did not...
ABSTRACT Background The role of microbiome, particularly Fusobacterium nucleatum ( Fn ), in periodontal disease and oral squamous cell carcinoma (OSCC) has been recently explored. This study aimed to evaluate the presence its levels rinse samples from Brazilian OSCC patients healthy individuals association with sociodemographic, clinical, health features. Methods In this case–control study, 80 participants were included, 31 49 without a cancer history. Clinical data collected, an exam was...