A5035672466- Cancer Cells and Metastasis
- Endodontics and Root Canal Treatments
- Oral and Maxillofacial Pathology
- Wnt/β-catenin signaling in development and cancer
- Dental materials and restorations
- Head and Neck Cancer Studies
- Laser Applications in Dentistry and Medicine
- Cancer-related gene regulation
- Mesenchymal stem cell research
- dental development and anomalies
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Immune cells in cancer
- Mast cells and histamine
- Soft tissue tumor case studies
- Asthma and respiratory diseases
- Bone Tumor Diagnosis and Treatments
- Caveolin-1 and cellular processes
- Oral microbiology and periodontitis research
- Hippo pathway signaling and YAP/TAZ
- Dental Trauma and Treatments
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Dental Anxiety and Anesthesia Techniques
- Bone and Dental Protein Studies
Universidade de São Paulo
2016-2025
Universidade Brasil
2019-2023
Queen Mary University of London
2013-2014
University of Dental Medicine
2014
Universidade Cidade de São Paulo
2011
The initiation or progression of periodontitis might involve a local renin-angiotensin system (RAS) in periodontal tissue. aim this study was to further characterize the RAS human and rat tissues between healthy periodontally-affected Components were investigated using vitro, ex vivo experiments involving both Wistar periodontium. Although not upregulated when challenged with P. gingivalis-lipopolysaccharide, gingival ligament fibroblasts expressed components. Likewise, inflamed gingiva...
Abstract Cells sorted from head and neck cancers on the basis of their high expression CD44 have potency for tumor initiation. These cells are also involved in epithelial to mesenchymal transition (EMT) we previously reported that cancer stem (CSCs) exist as two biologically distinct phenotypes. Both phenotypes CD44high but one is ESAhigh maintains characteristics, other ESAlow, has characteristics migratory. Examining CD44-regulated signal pathways these show CD44, RHAMM, act inhibit...
Dental socket repair theoretically involves a constructive inflammatory immune response, which evolves from an initial M1 prevalence to subsequent M2 dominance. In this scenario, the MEK1/2 signaling pathway is allegedly involved in polarization. This study aimed evaluate impact of pharmacological inhibition local host response and outcome. C57Bl/6-WT 8-week-old male mice were submitted extraction right upper incisor treated (or not, control group) with inhibitor PD0325901 (10 mg/kg/24 h/IP,...
Objective and methods: Among the cells involved in immune inflammatory responses periodontal disease, mast have been shown to be capable of generating a large number biologically active substances. The present study was undertaken identify quantify presence different stages human disease using histochemical (toluidine blue) immunohistochemical (tryptase‐positive cells) techniques. Results: Mast cell densities (cells per mm 2 ) were significantly increased chronic periodontitis/gingivitis...
The search for molecular markers to improve diagnosis, individualize treatment and predict behavior of tumors has been the focus several studies. This study aimed analyze homeobox gene expression profile in oral squamous cell carcinoma (OSCC) as well investigate whether some these genes are relevant prognosis and/or tumor aggressiveness. Homeobox levels were assessed by microarrays qRT-PCR OSCC tissues adjacent non-cancerous matched (margin), lines. Analysis microarray data revealed 147...
Oral squamous cell carcinoma (OSCC) is an extremely aggressive disease associated with a poor prognosis. Previous studies have established that cancer stem cells (CSCs) actively participate in OSCC development, progression and resistance to conventional treatments. Furthermore, CSCs frequently exhibit deregulated expression of normal signalling pathways, thereby acquiring their distinctive abilities, which self-renewal example. In this study, we examined the effects GLI3 knockdown OSCC, as...
Background Tumour metastasis has been associated with cancer stem cells, a small population stem‐like cells properties, higher rate of migration and metastatic potential compared to from the tumour bulk. Our aim was evaluate immunoexpression putative cell biomarkers ALDH 1 CD 44 in primary corresponding lymph nodes. Methods tissue specimens (n = 50) nodes 25) were surgically obtained 50 patients oral squamous carcinoma submitted immunohistochemistry. semi‐quantitatively scored according...
Abstract The aim of this study was to evaluate the immunolocalization dentin matrix protein (DMP)‐1 in human primary teeth treated with different pulp capping materials. Twenty‐five molars were divided into following groups: formocresol (FC), calcium hydroxide (CH), mineral trioxide aggregate (MTA), corticosteroid/antibiotic solution + CH (O CH), and Portland cement (PC), all received conventional pulpotomy treatment. at regular exfoliation period extracted for histological analysis DMP‐1....
Abstract Aim To report clinical complications (pain, necrotic gingival tissue and bone sequestration) resulting from accidental injection of sodium hypochlorite. Summary Root canal treatment is a routine procedure with few reported complications. Sodium hypochlorite (NaOCl) commonly used as an irrigant during the because its tissue‐dissolving, antibacterial lubricating properties. This paper presents case in which into lingual gingiva female patient caused necrosis. Surgical intervention was...
Homeobox genes are a family of transcription factors that play pivotal role in embryogenesis. Prospero homeobox 1 (PROX1) has been shown to function as tumor suppressor gene or oncogene various types cancer, including oral squamous cell carcinoma (OSCC). We have previously identified PROX1 downregulated OSCC. The aim this study is clarify the underlying mechanism by which regulates tumorigenicity OSCC cells. mRNA and protein expression levels were first investigated 40 samples nontumor...