A5019614384- Oral microbiology and periodontitis research
- Cancer-related Molecular Pathways
- Oral and Maxillofacial Pathology
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Salivary Gland Disorders and Functions
- Dental Radiography and Imaging
- Oral health in cancer treatment
- Molecular Biology Techniques and Applications
- Dental Health and Care Utilization
- interferon and immune responses
- Cervical Cancer and HPV Research
- HIV/AIDS oral health manifestations
- Cancer Research and Treatments
- Proteoglycans and glycosaminoglycans research
- RNA modifications and cancer
- Dental Implant Techniques and Outcomes
- Dysphagia Assessment and Management
- Bone Tumor Diagnosis and Treatments
- Bone Tissue Engineering Materials
- Salivary Gland Tumors Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Chemokine receptors and signaling
Hiroshima University
2016-2025
Hiroshima University of Economics
2022
Hiroshima Minami High School
2022
Queen Mary University of London
2013-2014
Tokyo Medical and Dental University
2009
The receptor for advanced glycation end-products (RAGE) is a newly recognized factor regulating cancer cell invasion and metastasis. This study investigated the expression of RAGE in gastric carcinomas its association with Of eight lines examined, seven constitutively expressed messenger ribonucleic acid (mRNA), MKN45 being exception. protein MKN28 cells treated antisense S-oligodeoxynucleotide was nine times less than that sense S-oligodeoxynucleotide-treated cells. Growth under treatment...
Abstract p63 is a member of the p53 family and regulates crucial events in formation epithelial structures, but role tumor unclear. We found that Snail-induced epithelial-to-mesenchymal transition (EMT) accompanied by down-regulation human squamous cell carcinomas (SCC). ΔNp63α predominantly expressed isoform SCC cells. ΔNp63 promoter activity required CAAT/enhancer binding protein (C/EBP) element was reduced remarkably Snail. Down-regulation reduction C/EBPα were observed EMT phenotype...
Abstract Cells sorted from head and neck cancers on the basis of their high expression CD44 have potency for tumor initiation. These cells are also involved in epithelial to mesenchymal transition (EMT) we previously reported that cancer stem (CSCs) exist as two biologically distinct phenotypes. Both phenotypes CD44high but one is ESAhigh maintains characteristics, other ESAlow, has characteristics migratory. Examining CD44-regulated signal pathways these show CD44, RHAMM, act inhibit...
The associations between oral human herpesvirus-6 (HHV-6) and HHV-7, periodontal conditions, lifestyle-related diseases, such as hypertension, diabetes, dyslipidemia, have not been fully investigated in older adults.Seventy-four patients who visited Hiroshima University Hospital were enrolled. Tongue swab samples employed, a real-time polymerase chain reaction was performed to detect HHV-6 HHV-7 DNA. Dental plaque accumulation, probing pocket depth, bleeding on (BOP) (i.e., sign of...
Resonance frequency analysis (RFA) was introduced as a method for measuring implant stability more than decade ago. Implant quotient (ISQ) values obtained using recently wireless RFA device have made it possible to evaluate in non-invasive technique; however, there are few studies of the factors that affect ISQ determined this device. The aim present study association between by and various related dental pig cortical bone model. Dental implants (Replace) Select Tapered implants) with length...
ABSTRACT Objective Cigarette smoking is associated with oral disease, whereas cigarette smoke extract (CSE) an aqueous solution containing most of the compounds and toxins inhaled by smokers. Although it has been reported that CSE directly affected dysfunctions in examinations various cell cultures, its effects on immune response to bacterial components keratinocytes remain largely unknown. The present study investigated chemokine expression induced Pam3CSK4 (Pam3), a mimic lipopeptide....
Background/Objectives: Nisin A, an antimicrobial peptide produced by Lactococcus lactis, primarily shows activity against Gram-positive bacteria, with efficacy increased when used in combination drug. On the other hand, oral candidiasis, caused Candida, occurs immunocompromised patients and requires antifungal therapy. However, drug-resistant Candida strains are increasing worldwide, leading to serious problems. Methods: To examine effects of nisin A species, we investigated combined drugs...
Acute respiratory failure (ARF) is a severe condition requiring intensive care unit (ICU) admission. Periodontal disease chronic inflammatory disorder caused by periodontal bacteria, though it unknown whether specific bacteria are associated with ARF patients admitted to the ICU. The present study was conducted compare oral environmental factors and numbers of between without related ICU A cross-sectional investigation performed 64 patients, divided into (n=18) non-ARF (n=46) groups based on...
ABSTRACT Aim Beclin‐1 (BECN1) is an autophagy‐related protein, and its expression related to prognosis of several human cancers. Whether autophagy involved in the cancer stem cell character oral cells has not been clear. The objective this study was investigate involvement BECN1 characteristics CD44 high cells. Methods (OM‐1 cells) were cultured on laminin 332–coated silicone gel. impact siRNA knockdown spheroid formation 5‐Fluorouracil (5‐FU)‐induced death investigated. A lactate...
Objective The objective of this study was to clarify significant risk factors for postoperative complications in the oral cavity patients who underwent surgery, excluding those with cancer. Material and Methods This reviewed records 324 mildly moderately invasive surgery (e.g., impacted tooth extraction, cyst excision, fixation mandibular maxillary fractures, osteotomy, resection a benign tumor, sinus lifting, bone grafting, removal sialolith, among others) under general anesthesia or...
The records of 70 patients with oral cancer who were treated at a single institution between 2008 and 2014 reviewed. body temperature, white blood cell count, C-reactive protein (CRP) levels compared those had received preoperative care (oral group) not any (non-oral group). When the divided into underwent minimally invasive surgery severely surgery, mean CRP level in early postoperative period was lower group as non-oral well surgery. However, most evidently reduced on days 1 3-5. no...
Abstract Objectives For people, it is challenging to be conscious of the appropriate toothbrushing time maintain good oral health in daily life. The aim this study was preliminarily examine utility an application (app) that combines a timer and information on toothbrushes. Materials Methods We developed “Toothbrushing Timer with Information Toothbrushes” app help users ensure learn about beneficial characteristics A total 18 participants were registered for study. At baseline (T0) after 1...
Abstract Objective The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer. Subjects Methods This retrospective cohort analyzed data from 140 cancer who underwent surgery at Hiroshima University Hospital May 2019 2022. Periodontal inflamed surface area (PISA) scores were determined assess severity using modified Nesse's methods. Propensity score matching used compare high low PISA...
<em>Capnocytophaga</em> species are commonly found in human oral microbiome. The aim of the present study was to understand association prevalence with hygiene and periodontal inflammation. A total 136 patients (median age 72 years) who visited Hiroshima University Hospital (Hiroshima, Japan) between April 2021 June 2023 were enrolled. Swab samples obtained from tongue surface. DNA (<em>C. ochracea</em> <em>C. sputigena</em>) detected by real‑time PCR analysis. Dental plaque accumulation...
Th1 and Th2 cytokines such as interferon-γ (IFN-γ ) , tumor necrosis factor- α (TNF-α ), IL-4 are expressed in T-cell-mediated inflammation the oral cavity. We tested hypothesis that those may act on CXCR3-agonistic chemokines, T-cell recruiting factors, neighboring cells, including keratinocytes fibroblasts. Human immortalized (RT7) fibroblasts (GT1) after 24-hour stimulation with IFN-γ showed increased mRNA levels of CXCL9 (600- 700-fold), CXCL10 (10,000- 150-fold), CXCL11 (5000-...
p63 is a member of the p53 family and DeltaNp63alpha dominant-expressing isoform in basal layer normal stratified epithelium human squamous cell carcinoma (SCC) cells. We have previously reported that down-regulation was accompanied with epithelial-to-mesenchymal transition (EMT) by Snail-expressing SCC cells, which re-expression diminished their invasiveness (Higashikawa K, Yoneda S, Tobiume Taki M, Shigeishi H, Kamata N. Snail-induced acquires invasive phenotype carcinoma. Cancer Res...
Oral keratinocytes and fibroblasts may be the first line of host defense against oral microorganisms. Here, contention that recognize microbial components via Toll-like receptors (TLRs) participate in development inflammation was examined. It found immortalized (RT7), (GT1) primary cells express mRNA TLRs 1-10. Interleukin-8 (IL-8) production by RT7 induced treatment with 1-9 exception TLR7 agonist, whereas GT1 were to produce IL-8 all TLR agonists tested except for TLR9. showed increased...