A5101423631- Oral microbiology and periodontitis research
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Periodontal Regeneration and Treatments
- Eosinophilic Esophagitis
- Oral health in cancer treatment
- Gastric Cancer Management and Outcomes
- Salivary Gland Disorders and Functions
- Head and Neck Cancer Studies
- Mesenchymal stem cell research
- Infective Endocarditis Diagnosis and Management
- Nerve injury and regeneration
- Trypanosoma species research and implications
- Bone and Joint Diseases
- Glycosylation and Glycoproteins Research
- Neutropenia and Cancer Infections
- Pediatric health and respiratory diseases
- Olfactory and Sensory Function Studies
- Cancer Diagnosis and Treatment
- Dental Health and Care Utilization
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Streptococcal Infections and Treatments
- Biochemical Analysis and Sensing Techniques
Hiroshima University
1998-2025
Hiroshima University Hospital
2019-2024
University of Pisa
2022
National Defense Medical College Hospital
2021-2022
National Hospital Organization Hokkaido Medical Center
2016
Sapporo National Hospital
2016
Frontier Science Foundation
2011
Saitama Children's Medical Center
2002
The University of Tokyo
2000
Nagoya City University
1998
Abstract Background : Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori , association this bacterium has also been discussed. The aim study was to investigate relationship between secretion, and H. infection. Methods presence infection, grade fundic atrophic gastritis (FAG), were investigated in 280 subjects without localized lesions upper gastrointestinal tract. infection confirmed by Giemsa immunohistochemical staining, FAG...
To address whether brain-derived neurotrophic factor (BDNF) could be involved in periodontal tissue regeneration, we examined the effects of BDNF on proliferation and expression bone (cementum)- related proteins (osteopontin, morphogenetic protein [BMP]-2, type I collagen, alkaline phosphatase [ALPase], osteocalcin) cultures human ligament (HPL) cells, which are thought to prerequisite for angiogenesis endothelial cells. Furthermore, effect regeneration tissues experimentally induced defects...
BACKGROUND: Recent studies have indicated an association between periodontitis and atrial fibrillation (AF), although the underlying mechanisms remain unclear. Porphyromonas gingivalis is a causative agent of periodontal disease highly pathogenic. This study focused on P aimed to investigate relationship among periodontitis, translocation , fibrosis AF. METHODS: An experiment was conducted using –infected C57BL/6J mice, in which inoculated into pulp molars. Immunohistochemistry used...
To clarify the roles of epithelial cell rests Malassez (ECRM) during periodontal repair, experimental root resorption was induced in rats and then ECRM that existed ligament cementum repair investigated using morphological immunohistochemical approaches. At day 7, after mechanical injury, observed were present adjacent to site lacunae. They These immunoreactive for bone morphogenetic protein-2. During stage early osteopontin ameloblastin. strongly reacted proliferating nuclear antigen. In...
The major problem in cell therapy is the possibility of viral or bacterial infection and immune reactions. Therefore, it expected culture cells which are intended to be re-implanted with autologous serum rather than conventional bovine serum. Cell human mesenchymal stem (hMSC), differentiating various cells, thought curative. To hMSC (HAS) re-implant them for therapy, we developed a completely closed bag system separating serum, comparing proliferation multipotency cultured HAS those foetal...
Abstract Objective The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer. Subjects Methods This retrospective cohort analyzed data from 140 cancer who underwent surgery at Hiroshima University Hospital May 2019 2022. Periodontal inflamed surface area (PISA) scores were determined assess severity using modified Nesse's methods. Propensity score matching used compare high low PISA...
Although the incidence of gastric carcinoma in japan has declined past several decades, there is no information about trends helicobacter pylori infection. The purpose study was to clarify H. infection and histologic gastritis young Japanese subjects evaluated between 1975 1978 (the 1970s) versus 1991 1994 1990s). prevalence grade biopsy specimens were 173 without localized lesions upper gastrointestinal tract. Findings 75 obtained from 1970s compared with those 98 1990s. (54.7%)...
Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be important infection route, it unknown whether environment associated with FN. The present study examined relationship between using periodontal inflamed surface area (PISA), a new disease parameter, and FN in hematologic cancer patients undergoing In this retrospective cohort study, 157 were divided into onset chemotherapy (n = 75) negative groups 82). associations of...
Abstract Purpose Several studies have found associations between periodontitis and various types of cancer. Since the site head neck cancer (HNC) has contiguity or proximity to oral cavity, it may be particularly influenced by inflammation. This study aimed determine whether HNC patients poor health as compared those with other Methods retrospectively examined environmental factors including periodontal inflamed surface area (PISA), a new inflammatory parameter. A total 1030 were divided...
Resin components, such as methyl methacrylate (MMA) can cause allergic contact dermatitis (ACD). Allergic reactions to resin are usually delayed. Only a few studies have reported dental allergy with acute symptoms. Here, case of ACD facial swelling after treatment using material is reported. A 55-year-old woman history periungual inflammation when gel nail polish had repeated episodes material. The temporary crown was removed, and symptoms were alleviated antihistamines corticosteroids. With...
Fujita T, Hayashida K, Shiba H, Kishimoto A, Matsuda S, Takeda Kawaguchi Kurihara H. The expressions of claudin-1 and E-cadherin in junctional epithelium. J Periodont Res 2010; 45: 579–582. © 2010 John Wiley & Sons A/S Background Objective: epithelium provides an important barrier against microbial invasion. Tight junction structural proteins called claudins are known to contribute the epithelial cell barrier. Junctional is located at a strategically interface between gingival sulcus...
Several cohort studies have shown that periodontal disease is associated with an increased risk for stroke. However, it remains unclear whether serum antibody titers a specific pathogen are outcome after ischemic stroke, and which kinds of pathogens We examined the relationship between IgG to in stroke patients. A total 445 patients acute (194 female [44.0%], mean age 71.9±12.3 years) were registered this study. Serum 9 (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans,...
Objective: The aim of this study was to clarify the mechanism inappropriate hypergastrinemia inHelicobacter pylori(H. pylori)-infected subjects. Methods: We measured fasting serum gastrin (SG) concentrations, and investigated immunohistochemically G D cell numbers in 47 subjects with normal mucosa, 24 chronic gastritis, duodenal ulcer (DU). degree inflammation atrophy were classified into four categories based on criteria established Sydney System: none, mild, moderate, severe. Avidin-biotin...
Stroke can be a cause of death, while in non-fatal cases it is common various disabilities resulting from associated brain damage. However, whether specific periodontal pathogen with increased risk unfavorable outcome after stroke remains unknown. We examined factors for following occurrence, including serum antibody titers to pathogens. The enrolled cohort included 534 patients who had experienced an acute stroke, were divided into favorable (n = 337) and 197) groups according modified...
Oral health conditions and cerebral small vessel disease, such as white matter lesions or microbleeds (CMBs), are associated with the incidence of stroke. The purpose this study was to examine associations between oral (serum IgG titers periodontal pathogens) presence severity CMBs in acute stroke patients. From January 2013 April 2016, patients were registered two hospitals. Serum samples evaluated for antibody against 9 pathogens using ELISA method. cut-off points reactivity (the positive...
We studied the relationship between Helicobacter pylori (H. pylori) infection and gastric acid secretion, along with fasting serum gastrin levels, in 55 asymptomatic healthy volunteers under 30 years old (29 H. pylori-positive, 26 pylori-negative). Mean scores of antral gastritis were significantly higher pylori-positive subjects than pylori-negative subjects. There was no significant difference both basal maximal output Fasting levels Sex did not affect scores, or although slightly men men....
Abstract Objective Whether oral health care during the perioperative period can lead to a better outcome after heart valve surgery has not been adequately elucidated. We examined effects of on postoperative inflammation response in patients who underwent surgery. Materials and Methods In this retrospective cohort study, 223 scheduled for single were divided into care, professional teeth cleaning or scaling within 3 days prior surgery, also following at least twice week ( n = 111), non‐oral...
Almost a quarter of century has passed since the term sarcopenia was defined. Sarcopenia is recognized as poor prognostic factor in variety cancer types. In ovarian cancer, it remains controversial whether affects prognosis and how should be evaluated. The present study aimed to evaluate association between volume psoas major muscle survival patients with epithelial cancer. Medical charts who received first‑line chemotherapy paclitaxel carboplatin at National Defense College Hospital...
The purpose of this study is to investigate regenerative process by immunohistochemical analysis and evaluate periodontal tissue regeneration following a topical application BDNF inflamed 3-wall intra-bony defects.
The present study investigated the presence of ET-1 in gingival crevicular fluid (GCF) from patients with periodontitis, and expression endothelins (ETs) their receptors mRNA cultured cells human periodontal tissues.ET was originally discovered as a potent vasoconstrictive peptide endothelial cells. It has been reported that ETs are produced by various besides related to inflammatory sclerotic lesions, such arteriolosclerosis hepatic cirrhosis. Therefore, may be involved disease. However,...
Mizuno N, Niitani M, Shiba H, Iwata T, Hayashi I, Kawaguchi Kurihara H. Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction. J Clin Periodontol 2011; 38: 310–317. doi: 10.1111/j.1600-051X.2010.01693.x. Abstract Aim: Some patients suffering from (Ag-P) also display In this study, we attempted identify the involved in Ag-P associated dysfunction using proteome analysis. Material and Methods: A two-dimensional fluorescence difference...