A5101563495- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Reproductive Biology and Fertility
- Occupational and environmental lung diseases
- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
- Vascular Anomalies and Treatments
- Cerebrovascular and genetic disorders
- Cancer therapeutics and mechanisms
- Uterine Myomas and Treatments
- Caveolin-1 and cellular processes
- Mechanical Circulatory Support Devices
- Emergency and Acute Care Studies
- Vascular Malformations Diagnosis and Treatment
- Hemophilia Treatment and Research
- Inflammatory Biomarkers in Disease Prognosis
National Defense Medical College
1997-2024
National Defense Medical College Hospital
2017-2021
Weatherford College
2021
Suzuki (Japan)
2021
National Defence Medical Centre
2019
Yokosuka Kyosai Hospital
2013
National Hospital Organization
2013
Hiroshima University
2007
Kansai Vocational College of Medicine
2004
Kaketsuken (Japan)
1985
The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte (PLR) have been reported to be useful as markers for prognostic factors metastasis in several cancers. aim of this study was identify predictor lymph node (LN) by NLR PLR patients with endometrial cancer.Medical charts cancers that received primary surgery at our hospital between 2007 2013 were retrospectively analyzed. cutoff value calculated from receiver operating characteristics (ROC) curve....
Recently, Bakri balloon (BBT) was effective for women with placenta previa to reduce hemorrhage. However, about 10% of needed receive an invasive strategy. Thus, the identification risk factors and development additional measurements BBT failure needed. The aim our study is investigate cause failing prophylactic in previa.Women who underwent cesarean section had a inserted during operation at institution between January 2015 December 2017 were enrolled. Patients requiring procedures after...
Abstract Background This study aimed to investigate the association between clinicopathologic factors, mesothelin, and cancer antigen (CA) 125 in endometrial carcinoma. Methods Between 1989 2017, patients with carcinoma who underwent total hysterectomy bilateral salpingo-oophorectomy at our hospital were identified. The either or both immunochemical expression of mesothelin CA125 clinicopathological features retrospectively examined. Results Among 485 patients, 171 positive for 368 CA125,...
Background/Aim: To investigate whether XIAP down-regulation and autophagy inhibition sensitize ovarian clear cell cancer cells to cisplatin. Materials Methods: The line KK was used for in vitro analysis. Hydroxychloroquine (HCQ) phenoxodiol (PXD) or embelin were as inhibitors, respectively. Non-specific XIAP-specific siRNAs transfected using Lipofectamine. Cytotoxicity assessed by MTT assays. Protein expression confirmed western blotting. Results: In KK, of specific together with HCQ...
Abstract Introduction Placenta previa with placenta accreta spectrum (PAS) is a life‐threatening disease that results in massive hemorrhage. The clinical and histologic criteria of PAS were adopted according to the International Federation Gynaecology Obstetrics (FIGO) classification. We aimed investigate whether FIGO topography associated maternal complications patients previa. Material methods Patients who underwent cesarean section at our institution between January 2003 December 2019...
Abstract Introduction Massive hemorrhage due to placenta previa with accreta spectrum is associated high maternal mortality and morbidity. Therefore, accurate prediction of essential; magnetic resonance imaging (MRI) a useful tool for this purpose. This study investigated novel predictors anterior posterior using MRI. Material methods was retrospective at tertiary obstetrics hospital in Japan. The singleton patients who were scanned MRI prenatally had cesarean section our institution between...
Aim: To examine the clinicopathological features of ovarian seromucinous borderline tumors (SMBTs) and compare them with those mucinous borderline/atypical proliferative (MB/APMTs). Patients Methods: SMBT between 2014 2018 MB/APMT 1988 who underwent surgery at our Institution were identified. Pathological review was conducted using World Health Organization criteria. Clinical compared retrospectively MB/APMT. Results: In total, 11 (12.9%) patients 74 (87.1%) included in study. The diagnosis...
Almost a quarter of century has passed since the term sarcopenia was defined. Sarcopenia is recognized as poor prognostic factor in variety cancer types. In ovarian cancer, it remains controversial whether affects prognosis and how should be evaluated. The present study aimed to evaluate association between volume psoas major muscle survival patients with epithelial cancer. Medical charts who received first‑line chemotherapy paclitaxel carboplatin at National Defense College Hospital...
The purpose of this study was to compare the clinical behavior several grades endometrioid carcinoma (EC) compared high-grade serous (HGSC), based on World Health Organization 2014 criteria.Clinicopathological features were between all EC and HGSC, HGSC either grade 1/2 or 3 EC.Sixty-five patients with 214 identified. Among EC, 56 displayed nine had EC. progression-free (PFS) overall (OS) survival better than those HGSC; however, PFS OS did not statistically differ HGSC. Grade but 3, a...
Among the four types of betanodaviruses, redspotted grouper nervous necrosis virus (RGNNV) has highest optimum temperature (25-30°C) for its multiplication. We tested 16 RGNNV isolates their sensitivity in cultured cells and demonstrated that upper limits ranged from less than 30°C to 35°C. At temperatures over limits, viral RNA replication was inhibited similarly. These results indicate mainly affect or earlier multiplication processes. The incompetence betanodaviruses at 37°C suggests...
Abstract Background Ascites cytology is important for determining the stage and treatment methods ovarian clear cell carcinoma (CCC) as defined by 2014 International Federation of Obstetrics Gynecology classification. Methods Patients with CCC who underwent surgery at our hospital between January 2012 December 2019 received cytodiagnosis their ascites using Papanicolaou (Pap) May–Grünwald–Giemsa (MGG) staining, block were identified. The technique was performed hematoxylin‐eosin (H&E)...
気管切開術後に約1%の頻度で起こるとされる致死的合併症である気管腕頭動脈瘻の1例を経験した. 予後はきわめて不良であり治療には大がかりな血管形成術などを必要とする. 治療がなされなければ救命されることはない. 気管腕頭動脈瘻は気管切開チューブやカフによる圧迫が気管と腕頭動脈壁の損傷をきたし, 瘻孔を形成し発生する. 脈管系の解剖学的変位などの要素も関与するため完全な予防は不可能であり, 気管切開術後は常に発生の危険が伴う. 発生頻度を低下させるには, 下位気管切開の回避, 気管切開チューブの適正なカフ圧管理, 腕頭動脈の走行確認などが肝要と思われた.
To determine whether CD44, which is associated with tumor growth and metastasis, related to carcinogenesis prognosis in ovarian mucinous carcinomas (MACs).Tissue blocks from 71 patients benign tumors were used the study: 35 borderline tumors, 60 MACs. Immunochemical analysis was performed evaluate expression of CD44 examine its association tumorigenesis survival.Compared had high levels (p=0.047). Conversely, MACs lower than (p=0.032). Progression-free overall survival MAC low worse those...
Abstract Aim To investigate the differences in epithelial‐mesenchymal transition (EMT)‐ and matrix metalloproteinases (MMP)‐related factors among placenta previa with without accreta spectrum (PAS) ( n = 69), normal 51). Methods The women diagnosed or PAS, placentas, who delivered at our institution between 2006 2016, were enrolled. difference of EMT‐related factors' expression by immunochemical analysis chorionic villi decidual cells PAS evaluated. Results In E‐cadherin decreased, while...
Abstract This study aimed to examine whether marginal sinus placenta previa, defined as when the just reaches internal cervical os and placental parenchyma might be >2 cm from os, can diagnosed using ultrasonography (US). We identified previa cases that underwent both US magnetic resonance imaging (MRI) between April 2010 December 2018 at our institution. The diagnostic discrepancies for MRI were examined retrospectively. Of 183 of 28 (15.3%) MRI. Among them, 18 (64.3%) could also US....
There is a similarity of histological features and survival between ovarian mucinous carcinoma (MC) with expansile invasion borderline tumor (MBT). The aim this study was to compare the clinical outcomes MC those MBT based on 2020 World Health Organization (WHO) criteria.A pathological review performed patients MC, MBT, seromucinous tumors that underwent surgery at our hospital 1984 2019. Clinicopathological were compared retrospectively MBT.Among 83 cases 85 12 tumor, 25 98 included through...
Abstract Introduction The kidneys, especially the proximal tubules, are most sensitive to cadmium. objective of this study was elucidate relationship between occupational exposure cadmium and renal damage in Japanese workers. Methods A dataset 4080 cases collected from nickel battery plants 1997 2020. Blood (Cd-B) used as an indicator urinary β2-microglobulin (B2M-U) damage. Cd-B < 1 μg/L set control ≥ 5 quintiles groups (< 1.51, 2.11, 2.81, 4.12, 4.12). β2-microglobulinuria...
The aim of the present study was to examine clinical outcome ovarian clear cell borderline tumor (CCBT) through pathological review for cases with carcinoma (CCC) and CCBT between 1984 2015 who received surgery at National Defense Medical College Hospital using 2020 World Health Organization (WHO) criteria. In addition definition in WHO criteria, atypia glandular epithelium without fibromatous component added diagnostic criteria CCBT. Two were identified current study. There no that changed...