A5007472687- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Intraperitoneal and Appendiceal Malignancies
- Maternal and Perinatal Health Interventions
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Reproductive Biology and Fertility
- Emergency and Acute Care Studies
- Drug Transport and Resistance Mechanisms
- Angiogenesis and VEGF in Cancer
- Vascular Tumors and Angiosarcomas
- Occupational and environmental lung diseases
- Aldose Reductase and Taurine
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Pharmacological Effects of Natural Compounds
- Renal function and acid-base balance
- Reproductive System and Pregnancy
- Renal and related cancers
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
National Defense Medical College Hospital
2020-2024
National Defence Medical Centre
2019-2024
National Defense Medical College
2020-2021
Saitama Prefecture
2021
Weatherford College
2021
Suzuki (Japan)
2021
Hyogo Medical University
1985-1994
Abstract Background This study aimed to investigate the association between clinicopathologic factors, mesothelin, and cancer antigen (CA) 125 in endometrial carcinoma. Methods Between 1989 2017, patients with carcinoma who underwent total hysterectomy bilateral salpingo-oophorectomy at our hospital were identified. The either or both immunochemical expression of mesothelin CA125 clinicopathological features retrospectively examined. Results Among 485 patients, 171 positive for 368 CA125,...
Abstract Introduction Placenta previa with placenta accreta spectrum (PAS) is a life‐threatening disease that results in massive hemorrhage. The clinical and histologic criteria of PAS were adopted according to the International Federation Gynaecology Obstetrics (FIGO) classification. We aimed investigate whether FIGO topography associated maternal complications patients previa. Material methods Patients who underwent cesarean section at our institution between January 2003 December 2019...
Abstract Introduction Massive hemorrhage due to placenta previa with accreta spectrum is associated high maternal mortality and morbidity. Therefore, accurate prediction of essential; magnetic resonance imaging (MRI) a useful tool for this purpose. This study investigated novel predictors anterior posterior using MRI. Material methods was retrospective at tertiary obstetrics hospital in Japan. The singleton patients who were scanned MRI prenatally had cesarean section our institution between...
Aim: To examine the clinicopathological features of ovarian seromucinous borderline tumors (SMBTs) and compare them with those mucinous borderline/atypical proliferative (MB/APMTs). Patients Methods: SMBT between 2014 2018 MB/APMT 1988 who underwent surgery at our Institution were identified. Pathological review was conducted using World Health Organization criteria. Clinical compared retrospectively MB/APMT. Results: In total, 11 (12.9%) patients 74 (87.1%) included in study. The diagnosis...
The aim of this study was to evaluate the clinicopathological factors and prognosis mucinous carcinoma (MC) with infiltrative invasion, MC expansile high-grade serous (HGSC).Cases HGSC between 1984 2019 were identified. invasion or retrospectively compared. Although our present included cases in previous studies, we extended observational period when analysis performed. Accordingly, added increased survival newly conducted.After pathological review, 27 25 219 included. had a better terms...
Abstract Background Ascites cytology is important for determining the stage and treatment methods ovarian clear cell carcinoma (CCC) as defined by 2014 International Federation of Obstetrics Gynecology classification. Methods Patients with CCC who underwent surgery at our hospital between January 2012 December 2019 received cytodiagnosis their ascites using Papanicolaou (Pap) May–Grünwald–Giemsa (MGG) staining, block were identified. The technique was performed hematoxylin‐eosin (H&E)...
Abstract Background Mucinous carcinoma (MC) is a histological subtype of ovarian cancer that has worse prognosis at advanced stages than the most prevalent subtype, high-grade serous carcinomas. Invasive patterns have been recognized as prognostic factors for MCs. MCs with infiltrative invasion were more aggressive those expansile invasion. MC an pattern exhibited behavior similar to mucinous borderline tumors (MBT). However, genomic analysis invasive insufficient. This study aimed compare...
Retained products of conception (RPOC) often cause severe postpartum hemorrhage (PPH) but the clinical significance RPOC in placenta previa is unclear. This study aimed to investigate women with previa. The primary outcome was evaluate risk factors and secondary consider PPH.Singleton pregnant who underwent cesarean section (CS) removal during operation at National Defense Medical College Hospital between January 2004 December 2021 were identified. A retrospective analysis performed examine...
Abstract Background Bevacizumab (Bev) plays the central role of adjuvant therapy for patients with ovarian carcinoma. The aim our study was to examine whether differences in administration Bev influence prognosis patients. Methods Patients carcinoma who received treatment at two hospitals between 1999 and 2020 were identified. treated weekly low-dose (100 mg on days 1 8 200 day 15, monthly) one hospital (group A) those monthly high-dose (15 mg/kg 1, another B) retrospectively compared....
There is a similarity of histological features and survival between ovarian mucinous carcinoma (MC) with expansile invasion borderline tumor (MBT). The aim this study was to compare the clinical outcomes MC those MBT based on 2020 World Health Organization (WHO) criteria.A pathological review performed patients MC, MBT, seromucinous tumors that underwent surgery at our hospital 1984 2019. Clinicopathological were compared retrospectively MBT.Among 83 cases 85 12 tumor, 25 98 included through...
Abstract Aim To investigate the differences in epithelial‐mesenchymal transition (EMT)‐ and matrix metalloproteinases (MMP)‐related factors among placenta previa with without accreta spectrum (PAS) ( n = 69), normal 51). Methods The women diagnosed or PAS, placentas, who delivered at our institution between 2006 2016, were enrolled. difference of EMT‐related factors' expression by immunochemical analysis chorionic villi decidual cells PAS evaluated. Results In E‐cadherin decreased, while...
Abstract This study aimed to examine whether marginal sinus placenta previa, defined as when the just reaches internal cervical os and placental parenchyma might be >2 cm from os, can diagnosed using ultrasonography (US). We identified previa cases that underwent both US magnetic resonance imaging (MRI) between April 2010 December 2018 at our institution. The diagnostic discrepancies for MRI were examined retrospectively. Of 183 of 28 (15.3%) MRI. Among them, 18 (64.3%) could also US....
The aim of the present study was to examine clinical outcome ovarian clear cell borderline tumor (CCBT) through pathological review for cases with carcinoma (CCC) and CCBT between 1984 2015 who received surgery at National Defense Medical College Hospital using 2020 World Health Organization (WHO) criteria. In addition definition in WHO criteria, atypia glandular epithelium without fibromatous component added diagnostic criteria CCBT. Two were identified current study. There no that changed...
The clinical significance of CD8-positive (CD8+ ) lymphocytes on tumor cell clusters ascites blocks in patients with ovarian high-grade serous carcinoma (HGSC) was investigated.Among HGSC who underwent surgery from January 2014 to December 2019, 38 block were selected. Using these and primary tissue, the presence CD8+ expression PD-L1 examined immunohistochemically. Tumor defined as clumps consisting more than 10 malignant cells block. Cases at least one lymphocyte cluster positive (Group...
The present study aimed to investigate the impact of cancer‑associated thromboembolism (CAT) on survival and biomarkers ovarian clear cell carcinoma (OCCC). Patients with OCCC who underwent surgery at National Defense Medical College Hospital (Tokorozawa, Japan) between January 2000 December 2019 were included in current study. Associations among CAT, clinicopathological features prognosis retrospectively compared. Furthermore, immunohistochemical staining was conducted all patients compare...
Background/Aim: We aimed to predict the prognosis of endometrial carcinoma by combining traditional histological classification with status tumor-infiltrating lymphocytes (TILs). Patients and Methods: All patients carcinoma, treated at our hospital, were classified into four categories—Category I: Type I positive for TILs; category II: type negative III: II IV: TILs. Prognoses compared across all categories. Positivity TILs was defined as a continuously formed thick zone invasive front....