A5075980865- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Oral microbiology and periodontitis research
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Infectious Encephalopathies and Encephalitis
- Antiplatelet Therapy and Cardiovascular Diseases
- EEG and Brain-Computer Interfaces
- Polyomavirus and related diseases
- Nutrition and Health in Aging
- Brain Metastases and Treatment
- Dysphagia Assessment and Management
- Pharmacological Effects and Toxicity Studies
- Atrial Fibrillation Management and Outcomes
- Autoimmune Neurological Disorders and Treatments
- Engineering Applied Research
- Climate Change and Health Impacts
- Telomeres, Telomerase, and Senescence
- Thermoregulation and physiological responses
Hiroshima University
2016-2025
Hiroshima University Hospital
2009-2025
University of Electro-Communications
2024
National Cerebral and Cardiovascular Center
2017-2018
Kobe University Hospital
2017-2018
Tokyo Women's Medical University
2018
Translational Research Informatics Center (Japan)
2018
Foundation for Biomedical Research and Innovation
2018
Center for Clinical Research (United States)
2018
Hoshigaoka Medical Center
2018
BackgroundAlthough statin therapy is beneficial for the prevention of initial stroke, benefit recurrent stroke and its subtypes remains to be determined in Asian, whom profiles are different from Caucasian. This study examined whether treatment with low-dose pravastatin prevents recurrence ischemic patients.MethodsThis a multicenter, randomized, open-label, blinded-endpoint, parallel-group patients who experienced non-cardioembolic stroke. All had total cholesterol level between 4.65 6.21...
<b><i>Background:</i></b> Periodontitis increases the risk of atherosclerotic cardiovascular disease and ischemic stroke. In this study, we evaluated whether serum antibody levels against individual periodontal pathogens are significantly associated with stroke subtypes their factors. <b><i>Methods:</i></b> Patients acute (n = 132; 74 male 58 female, 71.3 ± 10.7 years) patients no previous 77; 38 39 70.7 9.5 were consecutively enrolled in...
Dysphagia occurs in acute stroke patients at high rates, and many of them develop aspiration pneumonia. Team approaches with the cooperation various professionals have power to improve quality medical care, utilizing specialized knowledge skills each professional. In our hospital, a multidisciplinary participatory swallowing team was organized. The aim this study clarify influence approach on dysphagia by comparing rates pneumonia prior post organization. All consecutive who were admitted...
Synthetic magnetic resonance imaging (MRI) is an innovative MRI technology that enables the acquisition of multiple quantitative values, including T1 and T2 proton density, myelin volume, in a single scan. Although usefulness measurement with synthetic has been reported for assessing several diseases, investigations patients stroke have not reported. We aimed to explore utility quantification using predicting outcomes acute ischemic stroke. Patients (n=101) premorbid modified Rankin Scale...
Introduction: Oral carriage of Streptococcus mutans (the main pathogen dental caries), positive for cnm that encodes the collagen-binding protein Cnm, is associated with development hypertensive intracerebral hemorrhage and increase cerebral microbleeds (CMBs) in our retrospective observational studies. Herein, we prospectively investigated a relationship between Cnm-expressing S. CMBs longitudinal multicenter cohort study. Methods: We initiated multicenter, prospective study (RAMESSES: R...
Journal Article Accepted manuscript Seizure clusters with typical "evolution" in EEG Get access Miharuka Yokosaki, MD, MD Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School Biomedical Health Sciences Search for other works by this author on: Oxford Academic PubMed Google Scholar Shuichiro Neshige, PhD, PhD SciencesEpilepsy center, Hospital Corresponding Author: 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan, TEL: (+81)-82-257-5201, email: [email...
Aim: Although several studies have reported various causes of ischemic stroke in patients with cancer, only a few evaluated the clinical relevance pathogenesis to cancer. The aim present study was elucidate characteristics cancer‐associated stroke. Methods: We 154 without cancer and 57 who had either received continuous treatment for within 5 years before onset stroke, or been diagnosed 1 year after Cancer were grouped into “cancer‐associated stroke,” “conventional “other.” Results: A total...
The magnitude of the CHA2DS2-VASc score is associated with not only stroke incidence but also long-term outcomes. association between sex and initial severity in AF-related cardioembolic patients has been clarified. present study aimed to elucidate risk factors for among enrolled a multicenter registry.We selected 12,701 (age, 77±10 years; 5,653 women) from Japan Standard Stroke Registry Study January 2000 July 2013. Indicators National Institutes Health Scale (NIHSS) scores at admission...
There may be ethnic differences in carotid atherosclerosis and its contributing factors between Asian other populations. The purpose of this study was to examine intima-media complex thickness (IMT) the artery associated clinical Japanese stroke patients with hyperlipidemia from a cohort Japan Statin Treatment Against Recurrent Stroke Echo Study.Patients hyperlipidemia, not on statins, who developed noncardioembolic ischemic were included study. Mean IMT maximum distal wall common centrally...
Abstract Thus far, it is well known that increased blood pressure variability may exacerbate stroke outcomes. Blood in the acute phase would be influenced by both reactive hypertension to and intrinsic reactivity. Thus, we aimed evaluate association between outcomes at 3 months using ambulatory monitoring ischemic patients subacute after subsided. We retrospectively examined 626 consecutive with who underwent 24-hour during of (median, 9 days from onset). The was evaluated assessing standard...
Abstract Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed SLE undergoing immunosuppressive therapies, including azathioprine, presented cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency was subsequently PML. We evaluated cause disease activity PML, focusing on longitudinal...
Oral care is crucial for the prevention of cardiovascular events and pneumonia. However, few studies have evaluated associations between multidimensional assessments oral status or functional outcomes hospital-acquired pneumonia (HAP).
Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, progenitor cell (EPC) number were patients chronic stroke or risk factors.Patients a history any established factors enrolled study (n=102; 69 men,...
Background and Purpose— To define desirable target low-density lipoprotein (LDL) cholesterol levels for the prevention of stroke recurrence, a post hoc analysis was performed in J-STARS study (Japan Statin Treatment Against Recurrent Stroke). Methods— Subjects (n=1578) were divided into groups based on mean value postrandomized LDL until last observation 20 mg/dL increments. Adjusted hazard ratios (HRs) 95% confidence intervals analyzed each group, with adjustments baseline cholesterol, body...
Although MBs, ICH, and LI are secondary to cerebral microangiopathy, it remains unclear whether the location of subsequent ICH/LI corresponds previous MBs. We performed this study clarify positional relationship between recurrent previously detected MBs.We evaluated patients with who had as shown on prior T2*-weighted MR imaging. assessed retrospectively corresponded that MB. Patients ICH were divided into deep group lobar group, hematoma MBs was evaluated.A total 55 patients, including 34...
We hypothesized that meteorological conditions on the onset day and former days may play important roles in modulation of physical conditions. Associations factors their changes with stroke are interest. conducted a multicenter retrospective study to evaluate frequency events interaction daily changes. Acute patients (n = 3935, 73.5±12.4 years, 1610 females) who were admitted 7 hospitals three restricted areas enrolled this study. Poisson regression models involving time-lag variables was...